Correction of Hypothyroidism Leads to Change in Lean Body Mass without Altering Insulin Resistance

Sirigiri, Sangeetha; Vaikkakara, Suresh; Sachan, Alok; Srinivasarao, P; Epuri, Sunil; Anantarapu, Sailaja; Mukka, Arun; Chokkapu, Srinivasa Rao; Ashok, V.; Poojari, Ravi

doi:10.1159/000448889

Cited by 5 publications

(2 citation statements)

References 27 publications

(45 reference statements)

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“…No studies had investigated this feature; furthermore, it would be in contrast to what has been reported in human hypothyroid patients (Sirigiri et al . 2016, Stangierski et al . 2016).…”

Section: Discussionmentioning

confidence: 99%

Symmetric dimethylarginine concentrations in dogs with hypothyroidism before and after treatement with levothyroxine

Paola

Carotenuto

Dondi

et al. 2020

J of Small Animal Practice

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Objectives To evaluate the serum symmetric dimethylarginine (SDMA) and serum creatinine concentrations in a population of hypothyroid dogs at the time of diagnosis and after treatment. Materials and Methods Serum SDMA and serum creatinine were measured in serum samples of 24 healthy dogs and 24 hypothyroid dogs, at the time of diagnosis (T0) and after supplementation with levothyroxine (T1). Results The mean SDMA concentrations (reference intervals [RI] <18 μg/dL and <14 μg/dL depending on the source) were 11.7 ± 3.5 μg/dL, 13.8 ± 3.1 μg/dL and 11.83 ± 2.87 μg/dL in healthy dogs, and in the hypothyroid dogs at T0 and T1, respectively. The SDMA concentrations were higher in the hypothyroid dogs at T0 in comparison with the healthy dogs. Of the hypothyroid dogs, 1 out of 24 had an SDMA concentration above 18 μg/dL and 12 out of 24 above 14 μg/dL at T0. At T1, none of the hypothyroid dogs had SDMA concentrations above 18 μg/dL and two of them had SDMA concentrations above 14 μg/dL. The serum creatinine concentration was higher in the hypothyroid dogs at T0 as compared to the healthy dogs. At T0, 8 out of 24 hypothyroid dogs had serum creatinine concentrations above the RI (>1.4 mg/dL). In all but one dog, serum creatinine normalised after treatment. Clinical Significance The SDMA and serum creatinine concentrations were higher in hypothyroid dogs at diagnosis as compared to healthy dogs. Serum creatinine concentrations were increased in one‐third of the hypothyroid dogs and in the majority of cases normalised after levothyroxine supplementation. SDMA concentrations were rarely above the upper limit of the RI when the higest (<18 μg/dL) cut‐off was employed. The diagnostic accuracy of SDMA in dogs with thyroid dysfunction requires additional evaluation.

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“…No studies had investigated this feature; furthermore, it would be in contrast to what has been reported in human hypothyroid patients (Sirigiri et al . 2016, Stangierski et al . 2016).…”

Section: Discussionmentioning

confidence: 99%

Symmetric dimethylarginine concentrations in dogs with hypothyroidism before and after treatement with levothyroxine

Paola

Carotenuto

Dondi

et al. 2020

J of Small Animal Practice

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“…HYPOTHYROIDISM is a metabolic disease which is characterized by low level of thyroid hormone (TH) and high level of thyroid-stimulating hormone in serum [1]. TH plays an important role in regulating lipid and glucose metabolism and insulin signaling [2][3][4]. According to previous literature, TH stimulates cholesterol and other lipid synthesis, increases mobilization of plasma cholesterol and triglycerides (TG) [5][6][7].…”

mentioning

confidence: 99%

Gestational hypothyroidism elicits more pronounced lipid dysregulation in mice than pre-pregnant hypothyroidism

et al. 2020

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Thyroid hormone is crucial for regulating lipid and glucose metabolism, which plays essential role in maintaining the health of pregnant women and their offspring. However, the current literature is just focusing on the development of offspring born to the untreated mothers with hypothyroidism, rather than mothers themselves. Additionally, the interaction between hypothyroidism and pregnancy, and its impact on the women's health are still elusive. Therefore, this study was designed to compare the metabolic differences in dams with hypothyroidism starting before pregnancy and after pregnancy. Pre-pregnant hypothyroidism was generated in 5-week-old female C57/BL/6J mice using iodine-deficient diet containing 0.15% propylthiouracil for 4 weeks, and the hypothyroidism was maintained until delivery. Gestational hypothyroidism was induced in dams after mating, using the same diet intervention until delivery. Compared with normal control, gestational hypothyroidism exhibited more prominent increase than pre-pregnant hypothyroidism in plasma total cholesterol and lowdensity lipoprotein cholesterol, and caused hepatic triglycerides accumulation. Similarly, more significant elevations of protein expressions of SREBP1c and p-ACL, while more dramatic inhibition of CPT1A and LDL-R levels were also observed in murine livers with gestational hypothyroidism than those with pre-pregnant hypothyroidism. Moreover, the murine hepatic levels of total cholesterol and gluconeogenesis were dramatically and equally enhanced in two hypothyroid groups, while plasma triglycerides and protein expressions of p-AKT, p-FoxO1 and APOC3 were reduced substantially in two hypothyroid groups. Taken together, our current study illuminated that gestational hypothyroidism may elicit more pronounced lipid dysregulation in dams than dose the pre-pregnant hypothyroidism.

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Clinical Application of Gamitaeeumjowee-tang for Overweight or Obese Hypothyroidism Patients: A Retrospective Chart Review

Kim,

Won,

Kim

et al. 2023

JKOMOR

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Objectives: Weight gain is one of the symptoms of hypothyroidism and it could deteriorate thyroid function. Our objectives are to evaluate weight changes and analyze adverse events in overweight and obese women with hypothyroidism who were prescribed Gamitaeeumjowee-tang. Methods: A retrospective chart review was conducted using medical records of patients with hypothyroidism, who had body mass indexes (BMI) above 23 and were prescribed Gamitaeeumjowee-tang for 12 weeks between August 2017 and November 2022. Reported adverse events (AEs) were assessed by severity, causality and system-organ classes.Results: Thirty patients were included (mean±standard deviation, age 46.10±9.94 years, weight 70.52±11.18 kg, BMI 28.30±3.80 kg/㎡). The mean total weight loss of hypothyroidism patients was 5.45±2.77 kg, while the mean weight loss rate and mean BMI change were 7.66±3.41% and 2.18±1.07 kg/㎡, respectively. Among evaluated causality of adverse events, 'Unlikely' was predominant (80.8%) and severity assessment showed most of the symptoms were mild (91.7%). Conclusions: Gamitaeeumjowee-tang could be an option for hypothyroidism patients, who are overweight or obese, to lose weight and no serious adverse events occurred. Further well-designed clinical studies are recommended.

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Correction of Hypothyroidism Leads to Change in Lean Body Mass without Altering Insulin Resistance

Cited by 5 publications

References 27 publications

Symmetric dimethylarginine concentrations in dogs with hypothyroidism before and after treatement with levothyroxine

Symmetric dimethylarginine concentrations in dogs with hypothyroidism before and after treatement with levothyroxine

Gestational hypothyroidism elicits more pronounced lipid dysregulation in mice than pre-pregnant hypothyroidism

Clinical Application of Gamitaeeumjowee-tang for Overweight or Obese Hypothyroidism Patients: A Retrospective Chart Review

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