Correction of eye refraction by nonablative laser action on thermomechanical properties of cornea and sclera

Sobol, Emil N.; Bol'shunov, A V; Vorobieva, N. N.; Omelchenko, Alexander I.; Захаркина, О. Л.; Ignat’eva, N. Yu.; Grokhovskaya, T. E.; Лунин, В. В.

doi:10.1070/qe2002v032n10abeh002315

Cited by 11 publications

(6 citation statements)

References 1 publication

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“…Finally, the recent characterization of eyes mechanobiology has been fundamental in understanding their functioning, angiogenesis, pathologies progression, and therapeutic approaches efficacy [194,195,196]. For instance, ECM proteins that are secreted by the eye stroma in response to chronic inflammation might alter the mechanical integrity of the ECM, which leads to the activation of YAP/TAZ and β-catenin signalling pathways that, in turn, enhance the epidermal differentiation of the epithelium.…”

Section: Mechanobiology In Development and Pathologymentioning

confidence: 99%

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

Argentati

Morena

Tortorella

et al. 2019

IJMS

103

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The cross-talk between stem cells and their microenvironment has been shown to have a direct impact on stem cells’ decisions about proliferation, growth, migration, and differentiation. It is well known that stem cells, tissues, organs, and whole organisms change their internal architecture and composition in response to external physical stimuli, thanks to cells’ ability to sense mechanical signals and elicit selected biological functions. Likewise, stem cells play an active role in governing the composition and the architecture of their microenvironment. Is now being documented that, thanks to this dynamic relationship, stemness identity and stem cell functions are maintained. In this work, we review the current knowledge in mechanobiology on stem cells. We start with the description of theoretical basis of mechanobiology, continue with the effects of mechanical cues on stem cells, development, pathology, and regenerative medicine, and emphasize the contribution in the field of the development of ex-vivo mechanobiology modelling and computational tools, which allow for evaluating the role of forces on stem cell biology.

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Section: Mechanobiology In Development and Pathologymentioning

confidence: 99%

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

Argentati

Morena

Tortorella

et al. 2019

IJMS

103

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“…It is known that cartilage has much in common with cornea in chemical composition and physical properties; importantly, the property of temporal plasticity in the course of moderate laser heating also seems common. It is thus particularly attractive to transfer these emerging non‐destructive laser‐assisted techniques of cartilage reshaping to applications related to eye‐refraction correction . Transfer of such techniques to ophthalmology necessitates an accurate real‐time monitoring technology for measuring and controlling the temperatures and resulting opto‐thermal deformation of eye, in order to fully realize the unique advantages of such non‐destructive reshaping procedures.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape

Zaitsev

Matveyev

Matveev

et al. 2017

Journal of Biophotonics

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We describe the use of elastographic processing in phase-sensitive optical coherence tomography (OCT) for visualizing dynamics of strain and tissue-shape changes during laser-induced photothermal corneal reshaping, for applications in the emerging field of non-destructive and non-ablative (non-LASIK) laser vision correction. The proposed phase-processing approach based on fairly sparse data acquisition enabled rapid data processing and near-real-time visualization of dynamic strains. The approach avoids conventional phase unwrapping, yet allows for mapping strains even for significantly supra-wavelength inter-frame displacements of scatterers accompanied by multiple phase-wrapping. These developments bode well for real-time feedback systems for controlling the dynamics of corneal deformation with 10-100 ms temporal resolution, and for suitably long-term monitoring of resultant reshaping of the cornea. In ex-vivo experiments with excised rabbit eyes, we demonstrate temporal plastification of cornea that allows shape changes relevant for vision-correction applications without affecting its transparency. We demonstrate OCT's ability to detect achieving of threshold temperatures required for tissue plastification and simultaneously characterize transient and cumulative strain distributions, surface displacements, and scattering tissue properties. Comparison with previously used methods for studying laser-induced reshaping of cartilaginous tissues and numerical simulations is performed.

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“…for operations on trachea. It is known that eye cornea also is a collagenous tissue that is rather similar to cartilages in molecular composition and can also exhibit temporal plastification and reshaping under moderate laser-produced heating [5][6][7]. Thus, adaptation of thermo-mechanical laser technologies for reshaping cornea by analogy with reshaping of cartilaginous tissues can open unprecedented prospects for novel non-destructive methods of vision correction.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping

et al. 2016

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In the context of the development of emerging laser-assisted thermo-mechanical technologies for non-destructive reshaping of avascular collagenous tissues (cartilages and cornea), we report the first application of phase-sensitive optical coherence tomography (OCT) for visualizing transient strains involving supra-wavelength inter-frame displacements of scatterers. Usually phase-sensitive OCT assumes the visualization of sub-pixel and even sub-wavelength displacements of scatterers and fairly small strains (say, <10−3), which conventionally implies the necessity of averaging for enhancing the effective signal-to-noise ratio and, correspondingly, the application of small-amplitude actuators producing periodic deformations. The original approach used here allows for direct estimation of elevated strains ~10−2 (close to onset of intense speckle blinking) obviating the necessity of averaging and phase unwrapping for supra-wavelength inter-frame displacements. We demonstrate the possibility of mapping aperiodic thermally-induced transient strains with resultant large deformations on order of tens per cent. Such strains are typical in laser tissue reshaping, but are far beyond the range of conventionally discussed OCT-based strain mapping.

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Correction of eye refraction by nonablative laser action on thermomechanical properties of cornea and sclera

Cited by 11 publications

References 1 publication

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape

Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping

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