Correction of Essential Fatty-Acid Deficiency in Man by the Cutaneous Application of Sunflower-Seed Oil

Press, Martin; Hartop, P.J.; Prottey, C.

doi:10.1016/s0140-6736(74)92653-1

Cited by 123 publications

(35 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…490,[598][599][600] Topical therapy with sunflower-seed oil has also been found to correct cutaneous signs of EFA deficiency (ie, normalization of TEWL, resolution of dermatitis) in humans, including premature infants. 598,601,602 It has been ad-vanced that these beneficial effects may be due to increased metabolism of lipids in the epidermis, including active fatty-acid transport by keratinocytes, which makes it possible for even the immature epidermis of preterm infants to metabolize lipids derived from topically applied emollients and to utilize them as nutritional building blocks for the formation of a healthy, functional epidermal barrier. 455,490,603,604 Darmstadt et al 490 used a hairless-mouse model to demonstrate that the impact of topical therapy varies markedly with the product applied.…”

Section: Topical Emollient Therapymentioning

confidence: 99%

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

ABSTRACT. Background. Infant and under-5 childhood mortality rates in developing countries have declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and newborn mortality, have hardly changed. World leaders at the United Nations Millennium Summit in September 2000 agreed on a critical goal to reduce deaths of children <5 years by two thirds, but this may be unattainable without halving newborn deaths, which now comprise 40% of all under-5 deaths. Greater emphasis on wide-scale implementation of proven, cost-effective measures is required to save women's and newborns' lives. Approximately 99% of neonatal deaths take place in developing countries, mostly in homes and communities. A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developingcountry communities has not been reported.Objective. This review of community-based antenatal, intrapartum, and postnatal intervention trials in developing countries aimed to identify (1) key behaviors and interventions for which the weight of evidence is sufficient to recommend their inclusion in communitybased neonatal care programs and (2) key gaps in knowledge and priority areas for future research and program learning.Methods. Available published and unpublished data on the impact of community-based strategies and interventions on perinatal and neonatal health status outcomes were reviewed. Evidence was summarized systematically and categorized into 4 levels of evidence based on study size, location, design, and reported impact, particularly on perinatal or neonatal mortality. The evidence was placed in the context of biological plausibility of the intervention; evidence from relevant developed-country studies; health care program experience in implementation; and recommendations from the World Health Organization and other leading agencies.Results. A paucity of community-based data was found from developing-country studies on health status impact for many interventions currently being considered for inclusion in neonatal health programs. However, review of the evidence and consideration of the broader context of knowledge, experience, and recommendations regarding these interventions enabled us to categorize them according to the strength of the evidence base and confidence regarding their inclusion now in programs. This article identifies a package of priority interventions to include in programs and formulates research priorities for advancing the state of the art in neonatal health care.Conclusions. This review emphasizes some new findings while recommending an integrated approach to safe motherhood and newborn health. The results of this study provide a foundation for policies and programs related to maternal and newborn health and emphasizes the importance of health systems research and evaluation of interventions. The review offers compelling support for using research to identify the most effective measures to save newborn lives. It also may facilitate dialogue with policy...

show abstract

Section: Topical Emollient Therapymentioning

confidence: 99%

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Sunflower oil may be rubbed onto the Nightingale JMD. Management of patients with a short bowel 745 skin to ensure adequate amounts of essential fatty acids enter the body [144] . If a diet is high in monosaccharides D (-) lactic acidosis may occur (see below).…”

Section: Undernutrition -Protein-energy Malnutritionmentioning

confidence: 99%

“…There may be impairment of absorption of the fat-soluble vitamins A D E K and essential fatty acids. Essential fatty acid deficiency can be treated by rubbing sunflower oil into the skin [144] .…”

Section: Other Vitamin and Mineral Deficienciesmentioning

confidence: 99%

Management of patients with a short bowel

Nightingale

1999

Nutrition

View full text Add to dashboard Cite

“…When on parenteral nutrition the deficiencies depend on the regimen used, but iron, vitamin D. selenium [123] and biotin deficiencies may occur. Essential fatty acid deficiency can be treated bv rubbing sunflower oil into the skin [124],…”

Section: Micronutrientsmentioning

confidence: 99%

The Short Bowel Syndrome: What’s New and Old?

Nightingale

Lennard-Jones²

1993

Dig Dis

View full text Add to dashboard Cite

Conditions which resulted in colonic preservation such as strangulated hernia, intestinal volvulus, and mesenteric infarction were once the main reasons for a major intestinal resection leading to the short bowel syndrome. Now Crohn’s disease is the most common underlying diagnosis; such patients often have a jejunostomy. A measurement of the residual jejunal length from the duodenojejunal flexure makes possible predictions of patient outcome. Patients with a jejunostomy and less than 100 cm jejunum usually need long-term parenteral support, whereas 50 cm or more of jejunum usually suffices for adequate oral nutrition if the colon is preserved. While patients with and without a colon have problems with nutrient absorption, those with a jejunostomy also have problems of water, sodium and magnesium losses. Stomal losses may exceed oral intake and all such patients (‘secretors’) need parenteral supplements. Fluid and sodium losses can be reduced by octreotide, omeprazole or H₂ blockers but not sufficiently to avoid the need for intravenous supplements. Colonic preservation increases the incidence of calcium oxalate renal stones (20%). Patients with and without a colon have a high prevalence of gallstones (40%). Clinically important intestinal adaptation occurs in those with a colon but not in those with a jejunostomy. Many surgical techniques, including small bowel transplantation, have been suggested to improve absorption, but as the quality of life of most patients with a short bowel is good with current treatments, they are not at present recommended.

show abstract

Correction of Essential Fatty-Acid Deficiency in Man by the Cutaneous Application of Sunflower-Seed Oil

Cited by 123 publications

References 9 publications

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Management of patients with a short bowel

The Short Bowel Syndrome: What’s New and Old?

Contact Info

Product

Resources

About