Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo

Nirvanappa, Anilkumar C.; Mohan, Chakrabhavi Dhananjaya; Rangappa, Shobith; Ananda, Hanumappa; Sukhorukov, Alexey Yu.; Shanmugam, Muthu K.; Sundaram, Mahalingam S.; Nayaka, S. Chandra; Girish, K. S.; Chinnathambi, Arunachalam; Zayed, Mohamed E.; Alharbi, Sulaiman Ali; Sethi, Gautam; Basappa, Basappa; Rangappa, Kanchugarakoppal S.

doi:10.1371/journal.pone.0175659

Cited by 4 publications

(4 citation statements)

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“…On the other hand, stress stimuli such as tension, anxiety, and surgery stimulate macrophages and endothelial cells to produce inflammatory cytokines such as interleukin-6 (IL-6). IL-6 participates in the synthesis of numerous inflammatory factors, accelerates the inflammatory response, and exacerbates bodily damage [ 15 ]. Psychological stress causes excessive activity in the central nervous system and sympathetic nervous system, promoting the elevation of adrenocorticotropic hormone (ACTH), cortisol, and angiotensin II (ATII), leading to loss of appetite, sleep disorders, increased blood pressure, increased heart rate, and an increased risk of surgical complications, which affect the prognosis [ 14 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Application of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy

Wang,

2024

BMC Surg

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Background To explore the application effect of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy. Methods Eighty patients who underwent robot-assisted partial nephrectomy surgery between January 2022 and December 2023 were selected and divided into two groups according to the chronological order. The control group (n = 40) received preoperative assessment with verbal and video education from January 2022 to December 2022, while the observation group (n = 40) received preoperative assessment with 3D printing surgical training models combined with verbal and video education from January 2023 to December 2023. The preoperative anxiety, information demand score, and surgical awareness were compared between the two groups. The physiological stress indicators, including interleukin-6 (IL-6), angiotensin II (AT II), adrenocorticotropic hormone (ACTH), cortisol (Cor), mean arterial pressure (MAP), and heart rate (HR), were also measured at different time points before and after surgery.They were 6:00 am on the day before surgery (T0), 6:00 am on the day of the operation (T1), 6:00 am on the first day after the operation (T2), and 6:00 am on the third day after the operation (T3).The preparation rate before surgery was compared between the two groups. Results The anxiety and surgical information demand scores were lower in the observation group than in the control group before anesthesia induction, and the difference was statistically significant (P < 0.001). Both groups had lower scores before anesthesia induction than before preoperative assessment, and the difference was statistically significant (P < 0.05). The physiological stress indicators at T1 time points were lower in the observation group than in the control group, and the difference was statistically significant (P < 0.05). The overall means of the physiological stress indicators differed significantly between the two groups (P < 0.001). Compared with the T0 time point, the T1, T2, and T3 time points in both groups were significantly lower, and the difference was statistically significant (P < 0.05). The surgical awareness and preparation rate before surgery were higher in the observation group than in the control group, and the difference was statistically significant (P < 0.05). Conclusion The preoperative assessment mode using 3D printing surgical training models combined with verbal and video education can effectively reduce the psychological and physiological stress responses of surgical patients, improve their surgical awareness, and enhance the preparation rate before surgery.

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Section: Discussionmentioning

confidence: 99%

Application of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy

Wang,

2024

BMC Surg

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“…Then, ligand structures, including the novel isoxazole ( 7d ), triazole ( 5h ) analogues, and the co-crystal ligand, were prepared. The ligand structures were built and optimized using molecular modeling software (Discovery Studio & Avogadro) [ 46 ] to ensure proper geometry and energy minimization [ 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. The ligand structures were saved in the appropriate file format (PDB) for AutoDock4 Tools.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells

Vishwanath

Ravish

et al. 2023

Molecules

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Histone deacetylases (HDACs) are an attractive drug target for the treatment of human breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being used in preclinical and clinical studies. The need to understand the scope of the mode of action of HDACis, as well as the report of the co-crystal structure of HDAC6/SS-208 at the catalytic site, provoked us to develop an isoxazole-based lead structure called 4-(2-(((1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) pyrimidin-4-yl) morpholine (5h) and 1-(2-(((3-(p-tolyl) isoxazol-5-yl)methyl)thio) pyrimidin-4-yl) piperidin-4-one (6l) that targets HDACs in human BC cells. We found that the compound 5h or 6l could inhibit the proliferation of BC cells with an IC50 value of 8.754 and 11.71 µM, respectively. Our detailed in silico analysis showed that 5h or 6l compounds could target HDAC in MCF-7 cells. In conclusion, we identified a new structure bearing triazole, isoxazole, and thiouracil moiety, which could target HDAC in MCF-7 cells and serve as a base to make new drugs against cancer.

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“…We also reported the synthesis of benzoxazines and evaluated their antidiabetic activities [23]. Previously reported methods of synthesis of oxazines require strong basic or acidic conditions, heating, and prolonged reaction times, herein we report the design and synthesis of benzoxazines under mild reaction conditions [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Further, our in vitro RAGE-binding studies, computational docking studies towards RAGE binding, and anti-tuberculosis evaluation of benzoxazines have revealed a newly discovered structure in RAGE-related pathways of many diseases, including DM and TB.…”

Section: Introductionmentioning

confidence: 97%

Synthesis, Computational Studies, and Anti-Tuberculosis Activity of Benzoxazines That Act as RAGE Inhibitors

Bharathkumar

Srinivasan

Baday

et al. 2023

Applied Microbiology

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Novel benzoxazines were synthesized by microwave irradiation and tested for their potential binding affinity towards receptors of advanced glycation end products (RAGE). We found that the compound (2-(2-bromophenyl)-6-methyl-2,4-dihydro-1H-benzo[d][1,3]oxazine) (3i) is a lead inhibitor of RAGE. Further, our in silico prediction that benzoxazines dock towards the AGE binding region of RAGE suggests that these ligands could bind effectively at the hydrophobic pocket of the receptor and additionally form key interactions with Arg48 and Arg104, revealing its diversity in developing anti-RAGE drugs to treat AGE–RAGE-dominant disease conditions. Functionally, we herein report the anti-tuberculosis activity of small molecules which could be bioactive in the culture of mycobacterium tuberculosis.

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Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo

Cited by 4 publications

References 1 publication

Application of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy

Application of 3D printing surgical training models in the preoperative assessment of robot-assisted partial nephrectomy

Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells

Synthesis, Computational Studies, and Anti-Tuberculosis Activity of Benzoxazines That Act as RAGE Inhibitors

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