Correction: Modeling of In-Utero and Intra-Partum Transmissions to Evaluate the Efficacy of Interventions for the Prevention of Perinatal HIV

Sripan, Patumrat; Cœur, Sophie Le; Amzal, Billy; Ingsrisawang, Lily; Traisathit, Patrinee; Ngo‐Giang‐Huong, Nicole; McIntosh, Kenneth; Cressey, Tim R.; Sangsawang, Suraphan; Rawangban, Boonsong; Kanjanavikai, Prateep; Tréluyer, Jean‐Marc; Jourdain, Gonzague; Lallemant, Marc; Urien, Saı̈k

doi:10.1371/journal.pone.0137368

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“…Undetectable VL maintenance in gestation proved to be of great importance for preventing viral transmission. The HIV-1 MTCT occurs mainly during the third trimester of gestation by reduction in the placental vascular integrity [ 2 ], as we observed in our group.…”

Section: Discussionsupporting

confidence: 71%

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Clinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population

Leandro

Silva

Rodrigues

et al. 2023

Life

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Mother-to-children transmission (MTCT) is the main infection route for HIV-1 in children, and may occur during pregnancy, delivery, and/or postpartum. It is a multifactorial phenomenon, where genetic variants play an important role. This study aims at analyzing the influence of clinical epidemiological characteristics and a variant (rs12252) in interferon-induced transmembrane protein 3 (IFITM-3), a gene encoding an important viral restriction factor, on the susceptibility to HIV-1 mother-to-children transmission (MTCT). A case–control study was performed on 209 HIV-1-infected mothers and their exposed infected (87) and uninfected (122) children from Pernambuco, Brazil. Clinical–epidemiological characteristics are significantly associated with MTCT susceptibility. Transmitter mothers have a significantly lower age at delivery, late diagnosis, deficiency in ART use (pregnancy and delivery), and detectable viral load in the third trimester of pregnancy compared with non-transmitter mothers. Infected children show late diagnosis, vaginal delivery frequency, and tend to breastfeed, differing significantly from uninfected children. The IFITM-3 rs12252-C allele and TC/CC genotypes (dominant model) are significantly more frequent among infected than uninfected children, but the statistical significance does not remain when adjusted for clinical factors. No significant differences are observed between transmitter and non-transmitter mothers in relation to the IFITM-3 variant.

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Section: Discussionsupporting

confidence: 71%

“…Even in the absence of preventive measures, 55% to 85% of exposed children will not be infected [ 2 ], revealing that MTCT has a complex and multifactorial nature. Several clinical–epidemiological characteristics, such as antiretroviral therapy (ART) use, viral load, and CD4+ T cell levels, may contribute to MTCT.…”

Section: Introductionmentioning

confidence: 99%