Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

Colorectal cancer (CRC) is the third-commonest malignant cancer, and its metastasis is the major reason for cancer-related death. The process of metastasis is highly coordinated and involves a complex cascade of multiple steps. In recent years, miRNAs, as highly conserved, endogenous, noncoding, single-stranded RNA, has been confirmed to be involved in the development of various cancers. Considering that miRNA is also involved in a series of biological behaviors, regulating CRC occurrence and development, we review and summarize the role of miRNAs and related signaling pathways in several CRC-metastasis stages, including invasion and migration, mobility, metabolism, epithelial–mesenchymal transition, tumor-microenvironment communication, angiogenesis, anoikis, premetastatic–niche formation, and cancer stemness. In addition, we review the application of miRNAs as diagnostic CRC markers and in clinical treatment resistance. This review can contribute to understanding of the mechanism of miRNAs in CRC progression and provide a theoretical basis for clinical CRC treatment.

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<p>MicroRNAs: Multifaceted Regulators of Colorectal Cancer Metastasis and Clinical Applications</p>

Wen

Qian

Sun

et al. 2020

OTT

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Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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<p>MicroRNAs: Multifaceted Regulators of Colorectal Cancer Metastasis and Clinical Applications</p>

<p>MicroRNAs: Multifaceted Regulators of Colorectal Cancer Metastasis and Clinical Applications</p>

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