Correction: Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

Fothergill, Sarah Madeline; Joyce, Caoimhe; Xie, Fang

doi:10.1039/c8nr90234h

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“…The MEF caused by the improved absorption and emission characteristics of fluorescent molecules placed near a metal surface is closely related to the spectral overlap between the localized surface plasmon resonance (LSPR) of the metal nanostructure and the excitation/emission spectra of fluorophore. − The LSPR peak position and electric field enhancement of the GNRs depend on their size and shape. The transmission electron microscopy (TEM) micrograph shows that GNRs exhibit good monodispersibility and uniform morphology, with a mean size (length × width) of (34 ± 3) nm × (12 ± 2) nm (Figure S1a).…”

Section: Resultsmentioning

confidence: 99%

Quantitative Detection of Multiple Cardiovascular Biomarkers by an Antibody Microarray-Based Metal-Enhanced Fluorescence Assay

Jian,

Sun,

et al. 2024

Anal. Chem.

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Accurate detection of multiple cardiovascular biomarkers is crucial for the timely screening of acute coronary syndrome (ACS) and differential diagnosis from acute aortic syndrome (AAS). Herein, an antibody microarray-based metalenhanced fluorescence assay (AMMEFA) has been developed to quantitatively detect 7 cardiovascular biomarkers through the formation of a sandwich immunoassay on the poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate)-decorated GNRmodified slide (GNR@P(GMA-HEMA) slide). The AMMEFA exhibits high specificity and sensitivity, the linear ranges span 5 orders of magnitude, and the limits of detection (LODs) of cardiac troponin I (cTnI), heart-type fatty acid binding protein (H-FABP), C-reactive protein (CRP), copeptin, myoglobin, D-Dimer, and N-terminal pro-brain natriuretic peptide (NT-proBNP) reach 0.07, 0.2, 65.7, 0.6, 0.2, 8.3, and 0.3 pg mL −1 , respectively. To demonstrate its practicability, the AMMEFA has been applied to quantitatively analyze 7 cardiovascular biomarkers in 140 clinical plasma samples. In addition, the expression levels of cardiovascular biomarkers were analyzed by the least absolute shrinkage and selector operator (LASSO) regression, and the area under receiver operator characteristic curves (AUCs) of healthy donors (HDs), ACS patients, and AAS patients are 0.99, 0.98, and 0.97, respectively.

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Section: Resultsmentioning

confidence: 99%

Quantitative Detection of Multiple Cardiovascular Biomarkers by an Antibody Microarray-Based Metal-Enhanced Fluorescence Assay

Jian,

Sun,

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

show abstract

Correction: Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

Abstract: Correction for ‘Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window’ by Sarah Madeline Fothergill et al., Nanoscale, 2018, DOI: 10.1039/c8nr06156d.

Cited by 1 publication

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Quantitative Detection of Multiple Cardiovascular Biomarkers by an Antibody Microarray-Based Metal-Enhanced Fluorescence Assay

Quantitative Detection of Multiple Cardiovascular Biomarkers by an Antibody Microarray-Based Metal-Enhanced Fluorescence Assay

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