Correction: Lung cancer susceptibility from <i>GSTM1</i> deletion and air pollution with smoking status: a meta-prediction of worldwide populations

Yu, Ping; Kusuma, Joyce D.; Suarez, Maria; Shiao, S. Pamela K.

doi:10.18632/oncotarget.26388

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, a decreased MNCB frequency was observed in the variant allele carriers from E group compared to NE, similarly to the slight effect observed in E workers with normal allele, thus suggesting a possible interaction between tobacco smoke exposure and the genotype, in E group, in the genotoxic outcome observed. According to recent meta-analyses, GSTM1 and GSTT1 deletion as been associated with lung cancer in overall population (113,114), while no correlation was observed concerning GSTP1 105 , in overall population (115). Concerning DNA repair-genes, based on meta-analysis, XRCC1 399 and XRCC1 194 polymorphism were significantly associated with lung cancer risk in caucasions (116), and NBS1 195 in Asians, but not caucasions (117).…”

Section: Discussionmentioning

confidence: 99%

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Vital

Antunes

Louro

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

Environmental tobacco smoke (ETS) has been recognized as a major health hazard by environmental and public health authorities worldwide. In Portugal, smoke-free laws are in force for some years, banning smoking in most indoor public spaces. However, in hospitality venues such as restaurants and bars, owners can still choose between a total smoke-free policy or a partial smoking restriction with designated smoking areas, if adequate reinforced ventilation systems are implemented. Despite that, a previous study showed that workers remained continuously exposed to higher ETS pollution in Lisbon restaurants and bars where smoking was still allowed, comparatively to total smoke-free venues. This was assessed by measurements of indoor PM2.5 and urinary cotinine, a biomarkers of tobacco smoke exposure, demonstrating that partial smoking restrictions do not effectively protect workers from ETS. The aim of the present work was to characterize effect and susceptibility biomarkers in non-smokers from those hospitality venues occupationally exposed to ETS comparatively to non-exposed ones. A group of smokers was also included for comparison. The sister chromatid exchange (SCE), micronucleus (MN) and comet assays in whole peripheral blood lymphocytes (PBLs) and the micronucleus assay in exfoliated buccal cells, were used as biomarkers of genotoxicity. Furthermore, a comet assay after ex vivo challenge of leukocytes with an alkylating agent, ethyl methanesulfonate (EMS), was used to analyze the repair capacity of those cells. Genetic polymorphisms in genes associated with metabolism and DNA repair were also included. The results showed no clear association between occupational exposure to ETS and the induction of genotoxicity. Interestingly, the leukocytes from non-smoking ETS-exposed individuals displayed lower DNA damage levels in response to the ex vivo EMS challenge, in comparison to those from non-exposed workers, suggesting a possible adaptive response. The contribution of individual susceptibility to the effect biomarkers studied was unclear, deserving further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Vital

Antunes

Louro

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…This may explain why more female nonsmokers tend to suffer LUAD (Liu et al, 2006). Glutathione S transferase mu 1 (GSTM1) gene has been shown to be associated with lung cancer risk, and the GSTM1 enzyme plays a vital role in the detoxification pathway and protection against toxic insults (Yu et al, 2018). There are reports that GSTM1 has no relevant modifying effect on lung cancer risk and cumulative smoking dose (Schneider et al, 2004;Pisani et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Multiple genome pattern analysis and signature gene identification for the Caucasian lung adenocarcinoma patients with different tobacco exposure patterns

Dong

Qin

Tong

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background: When considering therapies for lung adenocarcinoma (LUAD) patients, the carcinogenic mechanisms of smokers are believed to differ from those who have never smoked. The rising trend in the proportion of nonsmokers in LUAD urgently requires the understanding of such differences at a molecular level for the development of precision medicine. Methods: Three independent LUAD tumor sample sets-TCGA, SPORE and EDRNwere used. Genome patterns of expression (GE), copy number variation (CNV) and methylation (ME) were reviewed to discover the differences between them for both smokers and nonsmokers. Tobacco-related signature genes distinguishing these two groups of LUAD were identified using the GE, ME and CNV values of the whole genome. To do this, a novel iterative multi-step selection method based on the partial least squares (PLS) algorithm was proposed to overcome the high variable dimension and high noise inherent in the data. This method can thoroughly evaluate the importance of genes according to their statistical differences, biological functions and contributions to the tobacco exposure classification model. The kernel partial least squares (KPLS) method was used to further optimize the accuracies of the classification models. Results: Forty-three, forty-eight and seventy-five genes were identified as GE, ME and CNV signatures, respectively, to distinguish smokers from nonsmokers. Using only the gene expression values of these 43 GE signature genes, ME values of the 48 ME signature genes or copy numbers of the 75 CNV signature genes, the accuracies of TCGA training and SPORE/EDRN independent validation datasets all exceed 76%. More importantly, the focal amplicon in Telomerase Reverse Transcriptase in nonsmokers, the broad deletion in ChrY in male nonsmokers and the greater amplification of MDM2 in female nonsmokers may explain why nonsmokers of both genders tend to suffer LUAD. These pattern analysis results may have clear biological interpretation in the molecular mechanism of tumorigenesis. Meanwhile, the identified signature genes may serve as potential drug targets for the precision medicine of LUAD.How to cite this article Dong Y-m, Qin L-d, Tong Y-f, He Q-e, Wang L, Song K. 2020. Multiple genome pattern analysis and signature gene identification for the Caucasian lung adenocarcinoma patients with different tobacco exposure patterns. PeerJ 8:e8349

show abstract

GSTM1 and GSTT1 polymorphisms in healthy volunteers – a worldwide systematic review

Nakanishi

Bertagnolli

Pita-Oliveira

et al. 2022

Drug Metabolism Reviews

View full text Add to dashboard Cite

Correction: Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status: a meta-prediction of worldwide populations

Cited by 3 publications

References 0 publications

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Multiple genome pattern analysis and signature gene identification for the Caucasian lung adenocarcinoma patients with different tobacco exposure patterns

GSTM1 and GSTT1 polymorphisms in healthy volunteers – a worldwide systematic review

Contact Info

Product

Resources

About