Correction: Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria

Vassallo, Christopher N.; Cao, Pengbo; Conklin, Austin C.; Finkelstein, Hayley; Hayes, Christopher S.; Wall, Daniel

doi:10.7554/elife.37049

Cited by 2 publications

(1 citation statement)

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“…In a second step, the toxin is then delivered to target cells where it takes full effect. This can be achieved by a transfer of outer membrane material that contains the toxic protein (Vassallo et al 2018; Figure 2I) or via the delivery of the toxic protein into the cytoplasm of the target cell using type III (Zhu et al 2006), IV (Souza et al 2015), VI (Crisan and Hammer 2020), or VII (Cao et al 2016) secretion systems (Figure 2J). Alternatively, other strains that try to invade a local group of bacteria can also be eradicated by releasing toxins (e.g.…”

Section: Detection and Recognition Mechanisms Are Often Highly Specificmentioning

confidence: 99%

Determinants of synergistic cell-cell interactions in bacteria

Pauli¹,

Ajmera²,

Kost³

2023

Preprint

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Bacteria are ubiquitous and colonize virtually every conceivable habitat on earth. To achieve this, bacteria require different metabolites and biochemical capabilities. Rather than trying to produce all of the needed materials by themselves, bacteria have evolved a range of synergistic interactions, in which they exchange different commodities with other members of their local community. While it is widely acknowledged that synergistic interactions are key to the ecology of both individual bacteria and entire microbial communities, the factors determining their establishment remain poorly understood. Here we provide a comprehensive overview over our current knowledge on the determinants of positive cell-cell interactions among bacteria. Taking a holistic approach, we review the literature on the molecular mechanisms bacteria use to transfer commodities between bacterial cells and discuss to which extent these mechanisms favour or constrain the successful establishment of synergistic cell-cell interactions. In addition, we analyse how these different processes affect the specificity among interaction partners. By drawing together evidence from different disciplines that study the focal question on different levels of organisation, this work not only summarizes the state of the art in this exciting field of research, but also identifies new avenues for future research.

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Section: Detection and Recognition Mechanisms Are Often Highly Specificmentioning

confidence: 99%

Determinants of synergistic cell-cell interactions in bacteria

Pauli¹,

Ajmera²,

Kost³

2023

Preprint

View full text Add to dashboard Cite

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A nuclease‐toxin and immunity system for kin discrimination in Myxococcus xanthus

Gong

Zhang

Liu

et al. 2018

Environmental Microbiology

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The use of toxin to attack neighbours and immunity proteins to protect against toxin has been observed in bacterial conflicts, including kin discrimination. Here, we report a novel nuclease-toxin and its immunity protein function in the colony-merger incompatibility, a kind of bacterial kin discrimination, in Myxococcus xanthus DK1622. The MXAN_0049 gene was determined to be a genetic determinant for colony-merger incompatibility, and the incompatibility could be eliminated by deletion of the upstream co-transcribed MXAN_0050 gene. We demonstrated that the MXAN_0050 protein was a nuclease, and MXAN_0049 protein was able to bind to MXAN_0050 to block nuclease activity in vitro. Expression of MXAN_0050 in Escherichia coli inhibited cellular growth, and the inhibition effect could be recovered by co-expression of MXAN_0049. We found that deletion of the PAAR-encoding gene (MXAN_0044) or the type VI secretion system led to the colony-merger and co-existence with the ΔMXAN_0049 mutant, suggesting that they were associated with colony-merger incompatibility. Homologues of the nuclease-toxin and cognate immunity pair are widely distributed in bacteria. We propose a simplified model to explain the kin discrimination mechanism mediated by the nuclease-toxin and immunity protein.© 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

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Correction: Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria

Cited by 2 publications

References 0 publications

Determinants of synergistic cell-cell interactions in bacteria

Determinants of synergistic cell-cell interactions in bacteria

A nuclease‐toxin and immunity system for kin discrimination in Myxococcus xanthus

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