Correction: In Vitro Acute Exposure to DEHP Affects Oocyte Meiotic Maturation, Energy and Oxidative Stress Parameters in a Large Animal Model

Ambruosi, Barbara; Uranio, M. Filioli; Sardanelli, Anna Maria; Pocar, Paola; Martino, Nicola Antonio; Paternoster, Maria Stefania; Amati, Francesca; Dell’Aquila, Maria Elena

doi:10.1371/annotation/4eeebe50-1b31-422c-94a0-effcf9eda85f

Cited by 14 publications

(3 citation statements)

References 43 publications

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“…Similarly, some EDCs were linked to decreased fertility and diminished ovarian reserves in women [30][31][32][33][34]. Animal studies confirmed that EDC exposure can affect mammary gland and uterine development, both in terms of timing and in terms of morphological changes and in silico analyses contributed to predict the mechanics behind this [16,35,36].…”

Section: Endocrine Disruptors and Human Healthmentioning

confidence: 89%

“…The most commonly used phthalate however, di-2-ethylhexyl phthalate (DEHP) have been linked with endocrine disrupting effects on the reproductive system due to his action as an androgen antagonist. DEHP has been correlated to lower fertility and sperm motility in males [90], to defective oocyte maturation [30,123], to anomalies in sexual development [122], to asthma [25], to breast cancer induction and to a wide range of other endocrine effects [124]. Recently, DEHP was categorized as a non-persistent endocrine disrupting compound by the world health organization (WHO).…”

Section: Phthalates and Perfluorinated Chemicalsmentioning

confidence: 99%

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Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

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Section: Endocrine Disruptors and Human Healthmentioning

confidence: 89%

Section: Phthalates and Perfluorinated Chemicalsmentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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“…There are two main ways in which sperm can encounter unmetabolized DEHP: via abrupt release from adipose tissue or through release from medical devices, such as a urological catheter-making unmetabolized DEHP a prominent threat to sperm fertility. DEHP exposure has been previously linked to increased ROS production in somatic cells and oocytes (Wu et al 2014;Tripathi et al 2019;Kim et al 2013;Ambruosi et al 2011). However, its impact on ROS over-production in sperm was not elucidated.…”

Section: Discussionmentioning

confidence: 99%

The impact of di-2-ethylhexyl phthalate on sperm fertility

Khasin

Rosa

Petersen

et al. 2020

Preprint

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A growing number of studies point to reduced fertility upon chronic exposure to endocrine-disrupting chemicals (EDCs) such as phthalates and plasticizers. These toxins are ubiquitous and are often found in food and beverage containers, medical devices, as well as in common household and personal care items. Animal studies with EDCs, such as phthalates and bisphenol A have shown a dose-dependent decrease in fertility and embryo toxicity upon chronic exposure. However, limited research has been conducted on the acute effects of these EDCs on male fertility. Here we used a murine model to test the acute effects of four ubiquitous environmental toxins: bisphenol A (BPA), di-2-ethylhexyl phthalate (DEHP), diethyl phthalate (DEP), and dimethyl phthalate (DMP) on sperm fertilizing ability and pre-implantation embryo development. The most potent of these toxins, di-2ethylhexyl phthalate (DEHP), was further evaluated for its effect on sperm ion channel activity, capacitation status, acrosome reaction and generation of reactive oxygen species (ROS). DEHP demonstrated a profound hazardous effect on sperm fertility by producing an altered capacitation profile, impairing the acrosome reaction, and, interestingly, also increasing ROS production. These results indicate that in addition to its known chronic impact on reproductive potential, DEHP also imposes acute and profound damage to spermatozoa, and thus, represents a significant risk to male fertility.

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