Correction: Impact of tooth brushing on oral bacteriota and health care-associated infections among ventilated COVID-19 patients: an intervention study

Gregorczyk-Maga, Iwona; Pałka, Anna; Fiema, Mateusz; Kania, Michał; Kujawska, Anna; Maga, Paweł; Jachowicz-Matczak, Estera; Romaniszyn, Dorota; Chmielarczyk, Agnieszka; Żółtowska, Barbara; Wójkowska‐Mach, Jadwiga

doi:10.1186/s13756-023-01256-6

Cited by 2 publications

(2 citation statements)

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“…These data confirm the findings from the 1970s ( 42 , 43 ) which demonstrated a continuum of lung colonization from the oropharyngeal cavity. However, if extended tooth brushing prevents oropharyngeal dysbiosis in patients receiving invasive mechanical ventilation, it was not effective in reducing the risk of nosocomial infections, including pneumonia ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients

Orieux,

Enaud,

Imbert

et al. 2023

Microbiol Spectr

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Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in critically ill-ventilated patients. Oropharyngeal and lung microbiota have been demonstrated to be associated with VAP occurrence, but the involvement of gut microbiota has not been investigated so far. Therefore, the aim of this study is to compare the composition of the gut microbiota between patients who subsequently develop VAP and those who do not. A rectal swab was performed at admission of every consecutive patient into the intensive care unit (ICU) from October 2019 to March 2020. After DNA extraction, V3-V4 and internal transcribed spacer 2 regions deep-sequencing was performed on MiSeq sequencer (Illumina) and data were analyzed using Divisive Amplicon Denoising Algorithm 2 (DADA2) pipeline. Among 255 patients screened, 42 (16%) patients with invasive mechanical ventilation for more than 48 h were included, 18 (43%) with definite VAP and 24 without (57%). Patients who later developed VAP had similar gut bacteriobiota and mycobiota α-diversities compared to those who did not develop VAP. However, gut mycobiota was dissimilar (β-diversity) between these two groups. The presence of Megasphaera massiliensis was associated with the absence of VAP occurrence, whereas the presence of the fungal genus Alternaria sp. was associated with the occurrence of VAP. The composition of the gut microbiota, but not α-diversity, differs between critically ill patients who subsequently develop VAP and those who do not. This study encourages large multicenter cohort studies investigating the role of gut-lung axis and oropharyngeal colonization in the development of VAP in ICU patients. Trial registration number: NCT04131569, date of registration: 18 October 2019. IMPORTANCE The composition of the gut microbiota, but not α-diversity, differs between critically ill patients who subsequently develop ventilator-associated pneumonia (VAP) and those who do not. Investigating gut microbiota composition could help to tailor probiotics to provide protection against VAP.

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Section: Discussionmentioning

confidence: 99%

The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients

Orieux,

Enaud,

Imbert

et al. 2023

Microbiol Spectr

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“…These infections, exemplified by those attributed to A. baumannii , have intensified the severity and risks associated with SARS-CoV-2 infection. 243 They play a significant role in the morbidity and mortality of COVID-19 patients. Individuals with COVID-19 who develop coinfections or secondary infections involving A. baumannii tend to experience more adverse outcomes, including prolonged hospital and ICU stays, as well as higher mortality rates.…”

Section: Pneumonia and Covid-19mentioning

confidence: 99%

Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event

Rangel,

De-Simone

2024

IDR

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Acinetobacter pneumonia is a significant healthcare-associated infection that poses a considerable challenge to clinicians due to its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted the need for effective treatment and management strategies for Acinetobacter pneumonia. In this review, we discuss lessons learned from recent world events, particularly the COVID-19 pandemic, in the context of the treatment and management of Acinetobacter pneumonia. We performed an extensive literature review to uncover studies and information pertinent to the topic. The COVID-19 pandemic underscored the importance of infection control measures in healthcare settings, including proper hand hygiene, isolation protocols, and personal protective equipment use, to prevent the spread of multidrug-resistant pathogens like Acinetobacter . Additionally, the pandemic highlighted the crucial role of antimicrobial stewardship programs in optimizing antibiotic use and curbing the emergence of resistance. Advances in diagnostic techniques, such as rapid molecular testing, have also proven valuable in identifying Acinetobacter infections promptly. Furthermore, due to the limited availability of antibiotics for treating infections caused A. baumannii , alternative strategies are needed like the use of antimicrobial peptides, bacteriophages and their enzymes, nanoparticles, photodynamic and chelate therapy. Recent world events, particularly the COVID-19 pandemic, have provided valuable insights into the treatment and management of Acinetobacter pneumonia. These lessons emphasize the significance of infection control, antimicrobial stewardship, and early diagnostics in combating this challenging infection.

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Correction: Impact of tooth brushing on oral bacteriota and health care-associated infections among ventilated COVID-19 patients: an intervention study

Cited by 2 publications

References 1 publication

The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients

The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients

Treatment and Management of Acinetobacter Pneumonia: Lessons Learned from Recent World Event

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