Correction: Hostile intruder: Toxoplasma holds host organelles captive

Coppens, Isabelle; Romano, Julia D.

doi:10.1371/journal.ppat.1007018

Cited by 2 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rearrangement of host organelles in T. gondii infected cells is well documented. For example, the mitochondria and rough ER physically associate with the PV (Sinai et al, 1997), and host endolysosomes and Rab vesicles cluster round the PV and have been implicated in nutrient uptake (Coppens et al, 2006;Coppens and Romano, 2018). It seems likely that T. gondii rearranges host MT networks in order to facilitate the rearrangement of intracellular organelles to the benefit of the parasite.…”

Section: Clasping Microtubules At the Schizont Surfacementioning

confidence: 99%

Theileria’s Strategies and Effector Mechanisms for Host Cell Transformation: From Invasion to Immortalization

Woods

Perry

Brühlmann

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

One of the first events that follows invasion of leukocytes by Theileria sporozoites is the destruction of the surrounding host cell membrane and the rapid association of the intracellular parasite with host microtubules. This is essential for the parasite to establish its niche within the cytoplasm of the invaded leukocyte and sets Theileria spp. apart from other members of the apicomplexan phylum such as Toxoplasma gondii and Plasmodium spp., which reside within the confines of a host-derived parasitophorous vacuole. After establishing infection, transforming Theileria species (T. annulata, T. parva) significantly rewire the signaling pathways of their bovine host cell, causing continual proliferation and resistance to ligand-induced apoptosis, and conferring invasive properties on the parasitized cell. Having transformed its target cell, Theileria hijacks the mitotic machinery to ensure its persistence in the cytoplasm of the dividing cell. Some of the parasite and bovine proteins involved in parasite-microtubule interactions have been fairly well characterized, and the schizont expresses at least two proteins on its membrane that contain conserved microtubule binding motifs. Theileria-encoded proteins have been shown to be translocated to the host cell cytoplasm and nucleus where they have the potential to directly modify signaling pathways and host gene expression. However, little is known about their mode of action, and even less about how these proteins are secreted by the parasite and trafficked to their target location. In this review we explore the strategies employed by Theileria to transform leukocytes, from sporozoite invasion until immortalization of the host cell has been established. We discuss the recent description of nuclear pore-like complexes that accumulate on membranes close to the schizont surface. Finally, we consider putative mechanisms of protein and nutrient exchange that might occur between the parasite and the host. We focus in particular on differences and similarities with recent discoveries in T. gondii and Plasmodium species.

show abstract

Section: Clasping Microtubules At the Schizont Surfacementioning

confidence: 99%

Theileria’s Strategies and Effector Mechanisms for Host Cell Transformation: From Invasion to Immortalization

Woods

Perry

Brühlmann

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…The coating of the Toxoplasma PV by the endoplasmic reticulum (ER), hereafter referred to as host ER association (hERa), was observed at the same time as mitochondria ( 4 , 5 ). Preliminary characterizations of hERa demonstrate that as with HMA, hERa stays intact even after aerolysin-induced ER vacuolization or cellular enucleation ( 19 ). Unlike HMA, hERa occurs early after Toxoplasma invasion but decreases as infection progresses ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Contact sites between host organelles and pathogens: boon or bane?

Mehra,

Pernas

2023

mSphere

View full text Add to dashboard Cite

A microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondria and the human parasite Toxoplasma gondii . We discuss open questions regarding their function during infection as well as those formed between the host endoplasmic reticulum and Toxoplasma .

show abstract

Correction: Hostile intruder: Toxoplasma holds host organelles captive

Cited by 2 publications

References 1 publication

Theileria’s Strategies and Effector Mechanisms for Host Cell Transformation: From Invasion to Immortalization

Theileria’s Strategies and Effector Mechanisms for Host Cell Transformation: From Invasion to Immortalization

Contact sites between host organelles and pathogens: boon or bane?

Contact Info

Product

Resources

About