Correction: Galectin-3 as a Marker and Potential Therapeutic Target in Breast Cancer

Zhang, Hao; Luo, Minna; Liu, Xi; Wang, Dan; Gu, Xiaohong; Duan, Chao; Gu, Huizi; Chen, Guanglei; Zhao, Xinhan; Zhao, Zuowei; Liu, Caigang

doi:10.1371/journal.pone.0232166

Cited by 2 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several tumor-invasiveness-related proteins were detected on our cell lines. Galectin 3, a β-galactoside-binding lectin, is a regulator of cell-cell and cell-matrix interactions [ 64 ]. EpCAM functions as an epithelium-specific intercellular adhesion molecule that can also initiate intracellular signaling, migration, differentiation, and proliferation [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines

et al. 2022

View full text Add to dashboard Cite

Tamoxifen is a long-known anti-tumor drug, which is the gold standard therapy in estrogen receptor (ER) positive breast cancer patients. According to previous studies, the conjugation of the original tamoxifen molecule with different functional groups can significantly improve its antitumor effect. The purpose of this research was to uncover the molecular mechanisms behind the cytotoxicity of different ferrocene-linked tamoxifen derivates. Tamoxifen and its ferrocene-linked derivatives, T5 and T15 were tested in PANC1, MCF7, and MDA-MB-231 cells, where the incorporation of the ferrocene group improved the cytotoxicity on all cell lines. PANC1, MCF7, and MDA-MB-231 express ERα and GPER1 (G-protein coupled ER 1). However, ERβ is only expressed by MCF7 and MDA-MB-231 cells. Tamoxifen is a known agonist of GPER1, a receptor that can promote tumor progression. Analysis of the protein expression profile showed that while being cytotoxic, tamoxifen elevated the levels of different tumor growth-promoting factors (e.g., Bcl-XL, Survivin, EGFR, Cathepsins, chemokines). On the other hand, the ferrocene-linked derivates were able to lower these proteins. Further analysis showed that the ferrocene-linked derivatives significantly elevated the cellular oxidative stress compared to tamoxifen treatment. In conclusion, we were able to find two molecules possessing better cytotoxicity compared to their unmodified parent molecule while also being able to counter the negative effects of the presence of the GPER1 through the ER-independent mechanism of oxidative stress induction.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Another important factor that have been detect through this investing the clinically significant of serum galectin-3 and BC of cancer grade (P: 0.034) and receptors (P: 0.037) which were supported by other studies that have similar results (Zhang, H., et al, 2020) (Zhang, H., et al, 2014) (Koo, J. S., & Jung, W., 2011) (K. Sujathan, et al, 2011). [[24][25][26][27]) which may by a highly remarkable marker in diagnosis and treatment plan as well as potential therapeutic target.…”

mentioning

confidence: 99%

Study of Serum Adiponectin, Leptin, and Galectin-3 in Breast Cancer

Ibrahim¹,

Ahmed²

2023

djm

View full text Add to dashboard Cite

Background: Breast cancer is the most common cancer that threatens the lives of women all over the world. Adipocytokines (adiponectin, leptin), and the β-galactoside-binding proteins (galectin-3) are new suggested parameters for the diagnosis and prognosis of breast cancer. Objective: To find relationship between serum adiponectin, leptin, and galectin-3 and breast cancer diagnosis and prognosis factors. Patients and Methods: A case-control study was done between (August 2021 to June 2022). Totally collected 111 female blood samples from patients that diagnosed with a breast cancer and healthy control, Samples were grouped into Group I (30 healthy control), Group II (43 patients pre-treatment), and Group III (38 patients post-treatment), from Rizgary Teaching Hospital, Nanakali Hospital, Hawler Teaching Hospital- General surgery and Neurosurgical Department, PAR Private Hospital, PAKY Hospital, and Rasul Private Hospital at Iraq-Erbil city and the age 18 up to 77 included in this study. Biochemical tests were performed (Adiponectin, Leptin, Galectin-3). These sample were analysed by using blood serum, statistically analysis the result. Results: The post-treatment, pre-treatment, and control in respectively about (60.52%, 60.46%, and 63.34%) were the majority of the study population (38-57) age group. There is a statistically significant differences between case and control groups in residency, family history, and BMI with a P-vale of (0.08, <0.001, 0.015), respectively. Leptin, adiponectin, and galectin-3 were statistically significant (0.007, <0.01, and <0.01), in respectively. About cancer characteristic galectin-3 was significant with (ER/PR) receptor (P:0.037) and grade (P:0.034), also leptin was significant with the grade (P: 0.025). Conclusion: We concluded that Adiponectin, Leptin, and Galectin-3 were new potential biochemical marker for diagnosis and prognosis the breast cancer, would be useful and important marker for assessing and evaluating grad, and receptor of the therapy plan.

show abstract

Correction: Galectin-3 as a Marker and Potential Therapeutic Target in Breast Cancer

Cited by 2 publications

References 1 publication

Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines

Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines

Study of Serum Adiponectin, Leptin, and Galectin-3 in Breast Cancer

Contact Info

Product

Resources

About