Correction: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue

Turchi, Riccardo; Tortolici, Flavia; Guidobaldi, Giulio; Iacovelli, Federico; Falconi, Mattia; Rufini, Stefano; Faraonio, Raffaella; Casagrande, Viviana; Federici, Massimo; Angelis, L. De; Carotti, Simone; Francesconi, Maria; Zingariello, Maria; Morini, Sergio; Bernardini, Roberta; Mattei, Maurizio; Rosa, Piergiorgio La; Piemonte, Fiorella; Lettieri-Barbato, Daniele; Aquilano, Katia

doi:10.1038/s41419-020-2347-x

Cited by 4 publications

(4 citation statements)

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“…Alternatively, increased levels of NfL could reflect other components of the pathophysiology of FRDA in a manner not directly associated with cell death. FRDA is associated with abnormalities in lipid metabolism as well as lipid peroxidation (Navarro et al, 2010;Obis et al, 2014;Abeti et al, 2016;Chen et al, 2016;Tamarit et al, 2016;Cotticelli et al, 2019;Turchi et al, 2020). Both could lead to membranes that are inherently more permeable than normal, with consequent loss of NfL from the cell.…”

Section: Discussionmentioning

confidence: 99%

The Role of Serum Levels of Neurofilament Light (NfL) Chain as a Biomarker in Friedreich Ataxia

et al. 2021

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Section: Discussionmentioning

confidence: 99%

The Role of Serum Levels of Neurofilament Light (NfL) Chain as a Biomarker in Friedreich Ataxia

et al. 2021

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“…p < 0.05 was considered to define statistical significance. Although no statistical analysis was performed to determine effect sizes aforehand, sample sizes here were similar to those researched in the same type of studies 34 , 43 , 44 .…”

Section: Methodsmentioning

confidence: 95%

ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

et al. 2021

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Adhesion G protein-coupled receptor A1 (ADGRA1, also known as GPR123) belongs to the G protein-coupled receptors (GPCRs) family and is well conserved in the vertebrate lineage. However, the structure of ADGRA1 is unique and its physiological function remains unknown. Previous studies have shown that Adgra1 is predominantly expressed in the central nervous system (CNS), indicating its important role in the transduction of neural signals. The aim of this study is to investigate the central function of Adgra1 in vivo and clarify its physiological significance by establishing an Adgra1-deficient mouse (Adgra1−/−) model. The results show that Adgra1−/− male mice exhibit decreased body weight with normal food intake and locomotion, shrinkage of body mass, increased lipolysis, and hypermetabolic activity. Meanwhile, mutant male mice present elevated core temperature coupled with resistance to hypothermia upon cold stimulus. Further studies show that tyrosine hydroxylase (TH) and β3-adrenergic receptor (β3-AR), indicators of sympathetic nerve excitability, are activated as well as their downstream molecules including uncoupling protein 1 (UCP1), coactivator 1 alpha (PGC1-α) in brown adipose tissue (BAT), and hormone-sensitive lipase (HSL) in white adipose tissue (WAT). In addition, mutant male mice have higher levels of serum T3, T4, accompanied by increased mRNAs of hypothalamus–pituitary–thyroid axis. Finally, Adgra1−/− male mice present abnormal activation of PI3K/AKT/GSK3β and MEK/ERK pathways in hypothalamus. Overexpression of ADGRA1 in Neuro2A cell line appears to suppress these two signaling pathways. In contrast, Adgra1−/− female mice show comparable body weight along with normal metabolic process to their sex-matched controls. Collectively, ADGRA1 is a negative regulator of sympathetic nervous system (SNS) and hypothalamus–pituitary–thyroid axis by regulating PI3K/AKT/GSK3β and MEK/ERK pathways in hypothalamus of male mice, suggesting an important role of ADGRA1 in maintaining metabolic homeostasis including energy expenditure and thermogenic balance.

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“…Brown adipose tissue (BAT) was first found in newborns and identified as a non-shivering thermogenic organ in 1961, which originates from the mesoderm during embryonic development . Due to the rich mitochondria and highly specific expression of uncoupling protein 1 (UCP1) as a biomarker, BAT has the function of burning fat and fueling thermogenesis . Until 2009, the discovery that functionally active brown adipose tissue is present in adult humans makes BAT the focus of antiobesity once again .…”

Section: Introductionmentioning

confidence: 99%

“…1 Due to the rich mitochondria and highly specific expression of uncoupling protein 1 (UCP1) as a biomarker, BAT has the function of burning fat and fueling thermogenesis. 2 Until 2009, the discovery that functionally active brown adipose tissue is present in adult humans makes BAT the focus of antiobesity once again. 3 More importantly, the amount of BAT is inversely correlated with the body mass index (BMI); especially, activation of BAT could lose body weight and lower blood glucose.…”

Section: ■ Introductionmentioning

confidence: 99%

Multiomics Approaches Identify Biomarkers for BAT Thermogenesis

Zhang,

Ma,

Wang

et al. 2023

J. Proteome Res.

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Brown adipose tissue (BAT) thermogenesis confers beneficial effects on metabolic diseases such as obesity and type-2 diabetes. Nevertheless, the mechanism and lipid driving the process that evokes this response have not been investigated yet. Here, a multiomics approach of integrative transcriptomics and lipidomics is used to explore the mechanism of regulating thermogenesis in BAT and providing promising lipid biomarkers and biomarker genes for thermogenic activators as antiobesity drugs. Lipidomics analysis demonstrated that a high abundance of glycerophospholipids and sphingolipids was more significant in BAT than in WAT. Enrichment analysis of upregulated DEGs between WAT and BAT screened suggested that the differences were mainly involved in lipid metabolism. Besides, β3-adrenergic agonist stimulation reduced the levels of TAG and DAG and increased the content of PC, PE, CL, and LPC and expression of genes involved in thermogenesis, fatty acid elongation, and glycerophospholipid metabolism in BAT. In this study, based on interpreting the inherent characterization of BAT as thermogenic tissue through comparison with WAT as fat storage tissue, adrenergic stimulation-induced BAT thermogenesis further identified specific lipid biomarkers (7 TAG species, 10 PC species, 1 LPC species, and 1 CL species) and Elovl3 and Crat gene biomarkers, which may provide targets for combating obesity by boosting BAT thermogenesis.

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Correction: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue

Cited by 4 publications

References 0 publications

The Role of Serum Levels of Neurofilament Light (NfL) Chain as a Biomarker in Friedreich Ataxia

The Role of Serum Levels of Neurofilament Light (NfL) Chain as a Biomarker in Friedreich Ataxia

ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

Multiomics Approaches Identify Biomarkers for BAT Thermogenesis

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