Correction for Dixit et al., “FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53”

Dixit, Updesh; Pandey, Ashutosh; Liu, Zhihe; Kumar, Sushil; Neiditch, Matthew B.; Klein, Kenneth M.; Pandey, Virendra N.

doi:10.1128/jvi.01609-17

Cited by 3 publications

(2 citation statements)

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“…An early study found that primary human DCs and cell lines transfected with DC-SIGN show extensive infection with DENV [ 64 ]. Subsequent studies confirmed that DC-SIGN mediates the infection of DCs by DENV and WNV and mediates the infection of mosquito cells by JEV [ 46 , 65 ]. In DENV, DCs showed no susceptibility to a viral strain containing two mutations in the E protein (N67 & T155), which demonstrated that DENV glycosylation sites are crucial for DC-SIGN-mediated infection [ 66 ].…”

Section: The Key Amino Acids Of the E Protein Involved In Flavivirus Early Infectionmentioning

confidence: 99%

The key amino acids of E protein involved in early flavivirus infection: viral entry

et al. 2021

Virol J

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Flaviviruses are enveloped viruses that infect multiple hosts. Envelope proteins are the outermost proteins in the structure of flaviviruses and mediate viral infection. Studies indicate that flaviviruses mainly use envelope proteins to bind to cell attachment receptors and endocytic receptors for the entry step. Here, we present current findings regarding key envelope protein amino acids that participate in the flavivirus early infection process. Among these sites, most are located in special positions of the protein structure, such as the α-helix in the stem region and the hinge region between domains I and II, motifs that potentially affect the interaction between different domains. Some of these sites are located in positions involved in conformational changes in envelope proteins. In summary, we summarize and discuss the key envelope protein residues that affect the entry process of flaviviruses, including the process of their discovery and the mechanisms that affect early infection.

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Section: The Key Amino Acids Of the E Protein Involved In Flavivirus Early Infectionmentioning

confidence: 99%

The key amino acids of E protein involved in early flavivirus infection: viral entry

et al. 2021

Virol J

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“…Although the lack of GAS2 and the presence of p53 were also found in the PLC5 and Huh7 cells, p53 mutation was reported in these two cell lines. PLC5 displayed Arg249Ser mutations in p53[22-24], while Tyr220Cys mutation of p53 was observed in Huh7[25-28]. Our subsequent functional analyses, by way of overexpression and knockdown approaches, illustrated that GAS2 inhibited the proliferation of HCC cells with wild-type functional p53.…”

Section: Discussionmentioning

confidence: 96%

Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis

Zhu

Cheng

Chan

et al. 2019

WJG

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BACKGROUND Growth arrest-specific gene 2 (GAS2) plays a role in modulating in reversible growth arrest cell cycle, apoptosis, and cell survival. GAS2 protein is universally expressed in most normal tissues, particularly in the liver, but is depleted in some tumor tissues. However, the functional mechanisms of GAS2 in hepatocellular carcinoma (HCC) are not fully defined. AIM To investigate the function and mechanism of GAS2 in HCC. METHODS GAS2 expression in clinic liver and HCC specimens was analyzed by real-time PCR and western blotting. Cell proliferation was analyzed by counting, MTS, and colony formation assays. Cell cycle analysis was performed by flow cytometry. Cell apoptosis was investigated by Annexin V apoptosis assay and western blotting. RESULTS GAS2 protein expression was lower in HCC than in normal tissues. Overexpression of GAS2 inhibited the proliferation of HCC cells with wide-type p53, while knockdown of GAS2 promoted the proliferation of hepatocytes ( P < 0.05). Furthermore, GAS2 overexpression impeded the G1-to-S cell cycle transition and arrested more G1 cells, particularly the elevation of sub G1 ( P < 0.01). Apoptosis induced by GAS2 was dependent on p53, which was increased by etoposide addition. The expression of p53 and apoptosis markers was further enhanced when GAS2 was upregulated, but became diminished upon downregulation of GAS2. In the clinic specimen, GAS2 was downregulated in more than 60% of HCCs. The average fold changes of GAS2 expression in tumor tissues were significantly lower than those in paired non-tumor tissues ( P < 0.05). CONCLUSION GAS2 plays a vital role in HCC cell proliferation and apoptosis, possibly by regulating the cell cycle and p53-dependent apoptosis pathway.

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Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis

Shao

Zhao

Dong

et al. 2019

WJG

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Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic disease. Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial. Based on a thorough literature review, we design a surgical algorithm for ZES and list some significant consensus findings and recommendations: (1) For sporadic ZES, surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging findings. The surgical approach for sporadic ZES depends on the lesion location (including the duodenum, pancreas, lymph nodes, hepatobiliary tract, stomach, and some extremely rare sites such as the ovaries, heart, omentum, and jejunum). Intraoperative liver exploration and lymphadenectomy should be routinely performed; (2) For multiple endocrine neoplasia type 1-related ZES (MEN1/ZES), surgery should not be performed routinely except for lesions > 2 cm. An attempt to perform radical resection (pancreaticoduodenectomy followed by lymphadenectomy) can be made. The ameliorating effect of parathyroid surgery should be considered, and parathyroidectomy should be performed first before any abdominal surgery for ZES; and (3) For hepatic metastatic disease, hepatic resection should be routinely performed. Currently, liver transplantation is still considered an investigational therapeutic approach for ZES. Well-designed prospective studies are desperately needed to further verify and modify the current considerations.

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Correction for Dixit et al., “FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53”

Abstract: Western blot for p53 in Fig. 4B was an inadvertent duplicate of the Western blot for p21 in Fig. 4C. The p53 blot in Fig. 4B should appear as shown below. We apologize for this mix-up. The correction to Fig. 4B does not affect the scientific results and conclusions.

Cited by 3 publications

References 0 publications

The key amino acids of E protein involved in early flavivirus infection: viral entry

The key amino acids of E protein involved in early flavivirus infection: viral entry

Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis

Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis

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