Correction for Cassinat et al., “New Role for Granulocyte Colony-Stimulating Factor-Induced Extracellular Signal-Regulated Kinase 1/2 in Histone Modification and Retinoic Acid Receptor <i>α</i> Recruitment to Gene Promoters: Relevance to Acute Promyelocytic Leukemia Cell Differentiation”

Cassinat, Bruno; Zassadowski, Fabien; Ferry, Christine; Llopis, Laura; Bruck, Nathalie; Lainey, Élodie; Duong, Vanessa; Cras, Audrey; Chourbagi, Oussama; Beinse, Guillaume; Fenaux, Pierre; Egly, C. Rochette; Chomienne, Christine

doi:10.1128/mcb.00222-17

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autophagosomes, vesicles containing intracellular materials, fuse with In a complementary way to ATRA, ATO binds to the PML CC-motif and B-box domain and is critical for the serial reactions of multimerization, SUMOylation, ubiquitination, and proteasomal degradation of the PML-RARA transcript. Given that ATO does not act on the NR or activate transcription, the differentiation of leukemic cells seen in the presence of ATO may in part be due to degradation of the PML-RARA transcript and restoration of normal RARA activity on gene promoters liberated from the malignant PML-RARA (Cassinat et al 2017). Importantly, the ATO-triggered degradation process contributes to the differentiation of APL cells because of its action on the SUMOylated K160 site on the PML protein.…”

Section: Summarizing the Synergism Between Ra And Ato In The Treatmen...mentioning

confidence: 99%

How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy

Korsos

Miller

2022

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Acute promyelocytic leukemia (APL) is associated with a severe coagulopathy leading to rapid morbidity and mortality if left untreated. The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosome 15 and 17. This t (15;17) results in a fusion transcript of the promyelocytic leukemia (PML) and retinoic acid receptor α (RARα) genes and expression of a functional PML/RARα protein. Detection of a fused PML/RARα genomic DNA sequence using florescent in-situ hybridization (FISH) or by detection of the PML/RARα fusion transcript via reverse transcriptase polymerase chain reaction (RT-PCR) has revolutionized the diagnosis and monitoring of APL. Once confirmed, APL is cured in over 90% of cases, making it the most curable subtype of acute leukemia today. Patients with low-risk APL are successfully treated using a chemotherapy-free combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). In this review, we explore the work that has gone into the modern-day diagnosis and highly successful treatment of this once devastating leukemia.

show abstract

Section: Summarizing the Synergism Between Ra And Ato In The Treatmen...mentioning

confidence: 99%