Correction: Flavonoid Rutin Increases Thyroid Iodide Uptake in Rats

Abstract

Thyroid iodide uptake through the sodium-iodide symporter (NIS) is not only an essential step for thyroid hormones biosynthesis, but also fundamental for the diagnosis and treatment of different thyroid diseases. However, part of patients with thyroid cancer is refractory to radioiodine therapy, due to reduced ability to uptake iodide, which greatly reduces the chances of survival. Therefore, compounds able to increase thyroid iodide uptake are of great interest. It has been shown that some flavonoids are able to increase iodide uptake and NIS expression in vitro, however, data in vivo are lacking. Flavonoids are polyhydroxyphenolic compounds, found in vegetables present in human diet, and have been shown not only to modulate NIS, but also thyroperoxidase (TPO), the key enzyme in thyroid hormones biosynthesis, besides having antiproliferative effect in thyroid cancer cell lines. Therefore, we aimed to evaluate the effect of some flavonoids on thyroid iodide uptake in Wistar rats in vivo. Among the flavonoids tested, rutin was the only one able to increase thyroid iodide uptake, so we decided to evaluate the effect of this flavonoid on some aspects of thyroid hormones synthesis and metabolism. Rutin led to a slight reduction of serum T4 and T3 without changes in serum thyrotropin (TSH), and significantly increased hypothalamic, pituitary and brown adipose tissue type 2 deiodinase and decreased liver type 1 deiodinase activities. Moreover, rutin treatment increased thyroid iodide uptake probably due to the increment of NIS expression, which might be secondary to increased response to TSH, since TSH receptor expression was increased. Thus, rutin might be useful as an adjuvant in radioiodine therapy, since this flavonoid increased thyroid iodide uptake without greatly affecting thyroid function.

The Effect of Locally Extracted aloe vera Oil on the Productive Performance of ISA Brown Laying Hens

“…The best performance was obtained in the T3 transaction compared to the rest of the transactions. The reason may be attributed to the role of the active compounds in aloe vera oil, the most important of which is the aloin and saponin, which may lead to increased absorption and readiness of elements within the gut [19], or due to the direct effect on the microorganisms inside the gut, which increases the beneficial bacteria at the expense of the harmful [20], which improves the health of the digestive system, and enhances the secretion of digestive enzymes, which benefits more from the amount of feed intake [21], or it may be attributed to aloe vera oil acting as an antioxidant and bacterial inhibitor, aAs well as the presence of flavonoids in increasing some important elements inside the body [22].…”

Effects of Alcoholic Extract of Myrtus communis L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats

“…Flavonoids are phenolic polyhydroxy compounds which are not only able to modulate NIS and thyroperoxidase as a key enzyme in the biosynthesis of thyroid hormones but also have anti-proliferative properties. Goncalves et al [13] showed that the consumption of flavonoid rutin led to a decrease in serum T 3 and T 4 , without changes in TSH and could significantly increase hypothalamic, pituitary and brown adipose tissue type 2 deiodinase. This could also end in a decrease in the activities of liver type 1 deiodinase.…”

Redifferentiation of radioiodine-refractory thyroid cancers

“…Other miscellaneous studies have highlighted the potential of other agents as candidates for redifferentiation strategy (Marsee et al 2004, Goncalves et al 2013, Bauriaud-Mallet et al 2019, Chai et al 2019, Vella et al 2019.…”