Correction: Discriminating Protective from Nonprotective <i>Plasmodium</i>-Specific CD8+ T Cell Responses

Doll, Katherine L.; Pewe, Lecia; Kurup, Samarchith P.; Harty, John T.

doi:10.4049/jimmunol.1600905

Cited by 2 publications

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“…These data suggested the intriguing hypothesis that expansion of the circulating T EM population induced by IAV infection could increase numbers of lung T RM . To test this hypothesis, we exposed PR8-GP33 immune or naive P14 recipient mice to systemic infection with recombinant Listeria monocytogenes expressing GP33 (LM-GP33) or an unrelated epitope derived from the Plasmodium berghei TRAP protein (LM-TRAP) (31,32) 45 days after the initial PR8-GP33 infection (Fig. 8A).…”

Section: Iav-induced Circulating Memory Cd8 T Cells Lose the Capacity...mentioning

confidence: 99%

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Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity

et al. 2017

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Lung resident memory (Trm) CD8 T cells induced by influenza A virus (IAV) are pivotal for providing heterosubtypic immunity, but are not maintained long term, causing gradual loss of protection. This contrasts sharply with long-term maintenance of Trm induced by localized infections of the skin and other tissues. Here we show that the decline in lung Trm is determined by an imbalance between apoptosis and lung recruitment and conversion to Trm of circulating memory cells. At the cellular level, circulating effector memory (Tem) rather than central memory (Tcm) cells are the precursors for conversion to lung Trm. Time-dependent changes in expression of genes critical for lymphocyte trafficking and Trm differentiation, in concert with enrichment of Tcm, diminish the capacity of circulating memory CD8 T cells to form Trm with time, explaining why IAV-induced Trm are not stably maintained. Importantly, systemic booster immunization, through increasing the number of circulating Tem cells, increases lung Trm, providing a potential new avenue for future IAV vaccines.

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Section: Iav-induced Circulating Memory Cd8 T Cells Lose the Capacity...mentioning

confidence: 99%

“…LCMV Armstrong infections were performed by IP injection of 2 × 10 5 PFU of the virus. Systemic booster/ mock booster immunizations were performed by IV injection of 10 7 colony-forming units of recombinant attenuated L. monocytogenes expressing GP33 (LM-GP33) or a P. berghei TRAP-derived epitope (LM-TRAP) (31).…”

Section: Viral and Bacterial Infectionsmentioning

confidence: 99%

Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity

et al. 2017

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“…Liver parasite burdens were assessed by quantitative real-time RT-PCR for parasite 18s rRNA in hepatocytes derived from mice challenged with Plasmodium sporozoites, as described before (Doll et al, 2016;Kurup et al, 2019). Total RNA was extracted from hepatocytes at the indicated time points post infection, using TRIzol (Sigma Aldrich) treatment, followed by DNase digestion, and cleanup with RNA Clean and Concentrator kit (Zymo Research).…”

Section: Acknowledgmentsmentioning

confidence: 99%