Correction: Development of Adenoviral Delivery Systems to Target Hepatic Stellate Cells In Vivo

Reetz, Julia; Genz, Berit; Meier, Claudia; Kowtharapu, Bhavani S.; Timm, Franziska; Vollmar, Brigitte; Herchenröder, Ottmar; Abshagen, Kerstin; Pützer, Brigitte M.

doi:10.1371/annotation/981389e9-e5a1-4be6-bf55-841a7102a623

Cited by 7 publications

(2 citation statements)

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“…The main purpose of these modifiers is to bring the virus in close proximity of an intended target cell and facilitate interaction. A few successful demonstrations are listed in Table 1 [127][128][129][130][131][132][133][134][135].…”

Section: Retargeting Of Adv By Affinity Modifiersmentioning

confidence: 99%

“…Antibody-antibody-based bridging molecules Anti-AdV protein conjugated to VEGFR, TIE-2, integrins, EPCAM, EGFR, HER2, Endoglin, HMWMAA [127][128][129][130][131][132] Antibody-ligand-based bridging molecules anti-AdV protein conjugated to Folate, TNFa, IGF1, EGF [133,134] Peptide-antibody-based bridging molecules p75 neurotropin receptor on hepatic stellate cells [135] Soluble receptors conjugated to ligands (sCAR, FX) EGF, anti-Cd40 ScFv, ApoE ligand, anti-ErbB2, anti-CEA, Polysialyc-acid (PSA), CXCL12 [136][137][138][139][140][141][142][143][144][145] BiTE, Leucine-zipper-based linkers CD44v6, anti-B-cell maturation antigen, FR-α, EGFR, EpCAM, carcinoembryonic antigen, CD40 [147][148][149][150][151][152][153][154] b. Selective Expression of Effectors (Inhibitors/Enhancers) in Specific Cells.…”

Section: Retargeting Of Adv By Affinity Modifiersmentioning

confidence: 99%

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Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity

Hajeri

Sharma

Yamamoto

2020

Cancers

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Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.

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