Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure

Ge, Moyar Q.; Kokalari, Blerina; Flayer, Cameron H.; Killingbeck, Sarah S.; Rédai, Imre; Macfarlane, Alexander W.; Hwang, Jin Wook; Kolupoti, Anisha; Kemeny, David M.; Campbell, Kerry S.; Haczku, Angela Franciska

doi:10.4049/jimmunol.1600095

Cited by 4 publications

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“…A study by Ge et al (48) showed that SP-D binds directly to pulmonary natural killer (NK) cells through the receptor NKp46 and thereby induces secretion of IFN-γ (Figure 3). This is the most specific receptor for NK cells and is expressed on the surface of all NK cell subsets (82, 83).…”

Section: In Vitro Studies Of Sp-d-mediated Cellular Effectsmentioning

confidence: 99%

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

2019

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Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is the major cause of cardiovascular disease and is a chronic inflammatory disorder in the arteries. Atherosclerosis is characterized by the accumulation of cholesterol, extracellular matrix, and immune cells in the vascular wall. Recently, the collectin surfactant protein-D (SP-D), an important regulator of the pulmonary immune response, was found to be expressed in the vasculature. Several in vitro studies have examined the role of SP-D in the vascular inflammation leading to atherosclerosis. These studies show that SP-D plays a dual role in the development of atherosclerosis. In general, SP-D shows anti-inflammatory properties, and dampens local inflammation in the vessel, as well as systemic inflammation. However, SP-D can also exert a pro-inflammatory role, as it stimulates C-C chemokine receptor 2 inflammatory blood monocytes to secrete tumor necrosis-factor α and increases secretion of interferon-γ from natural killer cells. In vivo studies examining the role of SP-D in the development of atherosclerosis agree that SP-D plays a proatherogenic role, with SP-D knockout mice having smaller atherosclerotic plaque areas, which might be caused by a decreased systemic inflammation. Clinical studies examining the association between SP-D and cardiovascular disease have reported a positive association between circulatory SP-D level, carotid intima-media thickness, and coronary artery calcification. Other studies have found that circulatory SP-D is correlated with increased risk of both total and cardiovascular disease mortality. Both in vitro, in vivo, and clinical studies examining the relationship between SP-D and CVDs will be discussed in this review.

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Section: In Vitro Studies Of Sp-d-mediated Cellular Effectsmentioning

confidence: 99%

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

2019

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“…Natural killer (NK) cells are an essential component of the anti-viral immune response. However, little is known about their interaction with SP-A and SP-D. A study by Ge et al demonstrated a decreased IFN-γ expression in SP-D knockout mice upon ozone exposure ( 69 ). The authors hypothesized that this decrease was as a result of the absence of SP-D interacting with the glycosylated NKp46 receptor on NK cells ( 69 ).…”

Section: Immunomodulatory Functions Of Sp-a and Sp-dmentioning

confidence: 99%

“…However, little is known about their interaction with SP-A and SP-D. A study by Ge et al demonstrated a decreased IFN-γ expression in SP-D knockout mice upon ozone exposure ( 69 ). The authors hypothesized that this decrease was as a result of the absence of SP-D interacting with the glycosylated NKp46 receptor on NK cells ( 69 ). They further postulated that this could play a role in the impaired dendritic cell homing to lymphoid tissue seen in SP-D knockout mice.…”

Section: Immunomodulatory Functions Of Sp-a and Sp-dmentioning

confidence: 99%

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

2021

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Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP-D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. Here, we review how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections. Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection while also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). Recombinant SP-A and SP-D could have therapeutic potential in neutralizing both current and future strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as well as modulating the inflammation-mediated pathology associated with COVID-19. A recombinant fragment of human (rfh)SP-D has recently been shown to neutralize SARS-CoV-2. Further work investigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated.

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“…SP-D воздействует на адаптивную иммунную систему, модулируя апоптоз Т-клеток [24][25][26]. Согласно [27], взаимодействие SP-A и SP-D с дендритными клетками происходит за Более глубокое и детальное изучение роли SP-A и SP-D позволяет предположить, насколько велико их значение для всего организма. За последние годы накоплено большое количество информации о системах внелегочных органов, в которых обнаружены данные белки.…”

Section: рис 1 процедура отбора источников для литературного обзораunclassified

SP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseases

Nikolaev,

Kharlamova,

Kosarev

et al. 2023

Sibirskij nauchnyj medicinskij zhurnal

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Surfactant proteins SP-A and SP-D, which belong to the family of collagen-containing type C lectins, are used as diagnostic and prognostic markers for many acute and chronic respiratory diseases. The aim of the study is to assess the impact of conventional risk factors for chronic non-infectious diseases on SP-A and SP-D protein levels by means of systemic and structural analysis on the basis of relevant publications from international databases and official WHO reports. This analytical review concludes that widespread expression of SP-A and SP-D is documented in numerous studies, and, although the lungs remain the main site of synthesis of surfactant proteins, one can expect its significant impact on the immune and inflammatory response in many organs and tissues. The authors note that there are several known extrapulmonary effects of these proteins. However, many mechanisms of additional cellular effects of SP-A and SP-D outside the bronchopulmonary system still remain unstudied, which indicates the prospects for further research in this area.

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Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure

Abstract: 2016. Cutting edge: role of NK cells and surfactant protein D in dendritic cell lymph node homing: effects of ozone exposure.

Cited by 4 publications

References 0 publications

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

SP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseases

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