Correction: CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon

Falcão, Luiz Fábio Magno; Falcão, Aline Semblano Carreira; Sousa, Rita Catarina Medeiros; Vieira, Waldonio de Brito; Oliveira, Robson Tadachi Moraes de; Normando, Valéria Marques Ferreira; Dias, George Alberto da Silva; Santos, Márcio Clementino de Souza; Rocha, Rodrigo Santiago Barbosa; Yoshikawa, Gilberto Toshimitsu; Koyama, Roberta Vilela Lopes; Fujihara, Satomi; Corrêa, Victor Augusto Cavaleiro; Fuzii, Hellen Thaís; Quaresma, Juarez Antônio Simões

doi:10.1371/journal.pone.0190436

Cited by 9 publications

(4 citation statements)

References 2 publications

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“…We show that may be a relationship between HTLV-1 infection and changes in pulmonary function, especially in individuals with HAM/TSP, which may progress to obstructive or restrictive lung disease, possibly related to pulmonary inflammation ( Normando et al, 2016 ; Falcão et al, 2017 ). A previous study observed obstructive disease in a suspect patient of bronchiolitis obliterans that was identified as HTLV-1 associated bronchioloalveolar disorder (HABA) with 1.25 l forced expiration volume in one second (FEV 1 ) (74.4% of predicted) and 64.1% forced expiratory volume in one second/forced vital capacity (FEV 1 /FVC) ( Yamakawa et al, 2015 ) due Adult T-cell leukemia ( Kimura, 1992 ).…”

Section: Ct Findings and Pulmonary Functionmentioning

confidence: 82%

“…In patients with HAM/TSP, combinations of alterations are frequently found in CT, including bronchiectasis and pleural thickening, bronchiectasis and parenchymal bands, bronchiectasis and interlobular septum thickening, bronchiectasis and centrilobular nodules, and centrilobular nodules and parenchymal bands, with some patients presenting three or more changes ( Falcão et al, 2017 ). Other imaging findings that reinforce the existence of a causal relationship between pulmonary diseases and HTLV-1, including findings of peripheral bronchioles and alveoli at sites of injury, probably due to BALF lymphocytosis ( Kawabata et al, 2012 ) as well as a higher prevalence of pneumonias among patients with HTLV-1 than that in the general population ( Yamashiro et al, 2012 ).…”

Section: Ct Findings and Pulmonary Functionmentioning

confidence: 99%

“…Low VC is related to restrictive lung disease, a reduction of FEV 1 is correlated with airway obstruction, and a reduction of MVV is related to both conditions and to reduced mobility. Therefore, it is possible that the lesions found in imaging studies associated with reduced mobility affecting patients with HAM/TSP play a key role in the development of obstructive or restrictive lung diseases ( Falcão et al, 2017 ). It is possible that bronchiectasis and pleural thickening play key roles in the development of obstructive disease and restrictive lung disease, respectively.…”

Section: Ct Findings and Pulmonary Functionmentioning

confidence: 99%

“…A relationship between HTLV-1 and pulmonary diseases was established with reports of individuals with TSP/HAM who exhibit pulmonary diseases with characteristics of lymphocytic inflammatory infiltrate ( Sugimoto et al, 1987 ) and later by other authors ( Teruya et al, 2008 ; Kawabata et al, 2012 ; Nakayama et al, 2013 ), include opportunistic pulmonary infections ( Taylor and Matsuoka, 2005 ) and alterations in CT images in infected individuals ( Kikuchi et al, 1996 ; Tateishi et al, 2001 ; Kadota et al, 2004 ; Okada et al, 2016 ; Einsiedel et al, 2014 ; Yamakawa et al, 2015 ; Falcão et al, 2017 ).…”

Section: Introductionmentioning

confidence: 96%

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Human T Lymphotropic Virus and Pulmonary Diseases

Dias

Falcão

et al. 2018

Front. Microbiol.

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Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy, and adult T cell lymphoma/leukemia (ATL/L). Pulmonary complications such as alveolitis and bronchiectasis were found in individuals who develop TSP/HAM due to chronic inflammation. These individuals showed image anomalies in CT scans and changes in pulmonary function parameters distinctive of pulmonary disease. Furthermore, infected individuals have a greater susceptibility to pulmonary tuberculosis either due to changes in the innate immune response, in asymptomatic carriers, or to an opportunistic disease linked to immunodepression, in individuals who develop ATL/L. This summary addresses the general lack of knowledge regarding the relationship between HTLV-1 and pulmonary diseases and provides direction for future work.

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Section: Ct Findings and Pulmonary Functionmentioning

confidence: 82%

Section: Ct Findings and Pulmonary Functionmentioning

confidence: 99%

Section: Ct Findings and Pulmonary Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Human T Lymphotropic Virus and Pulmonary Diseases

Dias

Falcão

et al. 2018

Front. Microbiol.

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High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma – implications for staging

Acuña-Villaorduña

Gonzalez-Lugo

et al. 2019

Leukemia & Lymphoma

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HTLV in South America: Origins of a silent ancient human infection

Ishak

Azevedo

et al. 2020

Virus Evolution

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The description of the first human retrovirus, Human T-lymphotropic virus 1 (HTLV-1), was soon associated with an aggressive lymphoma and a chronic inflammatory neurodegenerative disease. Later, other associated clinical manifestations were described, affecting diverse target organs in the human body and showing the enormous burden carried by the virus and the associated diseases. The epidemiology of HTLV-1 and HTLV-2 showed that they were largely distributed around the world, although it is possible to locate geographical areas with pockets of low and very high prevalence and incidence. Aboriginal Australians and indigenous peoples of Brazil are examples of the large spread of HTLV-1 and HTLV-2, respectively. The epidemiological link of both situations is their occurrence among isolated, epidemiologically closed or semi-closed communities. The origin of the viruses in South America shows two different branches with distinct timing of entry. HTLV-1 made its probable entrance in a more recent route through the east coast of Brazil at the beginning of the slave trade from the African continent, starting in the 16th century and lasting for more than 350 years. HTLV-2 followed the ancient route of human migration from the Asian continent, crossing the Behring Strait and then splitting in South America as the population became separated by the Andes Mountains. By that time, HTLV-2c probably arose and became isolated among the indigenous populations in the Brazilian Amazon. The study of epidemiologically closed communities of indigenous populations in Brazil allowed tracing the most likely route of entry, the generation of a new molecular subtype (HTLV-2c), the elucidation of the vertical transmission of HTLV-2, the intrafamilial aggregation of cases and the escape and spread of the virus to other areas in Brazil and abroad. Despite the burden and impact of both viruses, they are maintained as silent infections among human populations because (i) health authorities in most South American countries in which national surveillance is poor have little interest in the disease, (ii) the information is commonly lost as indigenous groups do not have specific policies for HTLV and other sexually transmitted infections, and (iii) health access is not feasible or properly delivered.

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Correction: CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon

Cited by 9 publications

References 2 publications

Human T Lymphotropic Virus and Pulmonary Diseases

Human T Lymphotropic Virus and Pulmonary Diseases

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma – implications for staging

HTLV in South America: Origins of a silent ancient human infection

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