Correction: Corrigendum: Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet

Song, Lanying; Qu, Dan; Zhang, Qing; Jiang, Jing; Zhou, Haiyue; Jiang, Rui; Li, Yating; Zhang, Yao; Yan, Hongli

doi:10.1038/srep46884

Cited by 6 publications

(3 citation statements)

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“…Multiple studies have indicated increased amounts of MDA, as measured by the TBAR assay, and OxLDL levels in human NAFLD and NASH patients in comparison to control subjects (15,(35)(36)(37)(38)(39). In addition, the presence of MDA adducts in livers has been documented for several different experimental rat and mouse models of NAFLD and NASH (40)(41)(42)(43). In line with these publications, work from our group indicated the presence of MDA adducts in livers of human NASH (44), as well as during steatohepatitis in hypercholesterolemic Ldlr −/− mice on highfat high-cholesterol diet (45), a murine model resembling human lipid profiles of NAFLD (46).…”

Section: Ose Presence In Nafldmentioning

confidence: 99%

Oxidation-Specific Epitopes in Non-Alcoholic Fatty Liver Disease

Hendrikx

Binder

2020

Front. Endocrinol.

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An improper balance between the production and elimination of intracellular reactive oxygen species causes increased oxidative stress. Consequently, DNA, RNA, proteins, and lipids are irreversibly damaged, leading to molecular modifications that disrupt normal function. In particular, the peroxidation of lipids in membranes or lipoproteins alters lipid function and promotes formation of neo-epitopes, such as oxidation-specific epitopes (OSEs), which are found to be present on (lipo)proteins, dying cells, and extracellular vesicles. Accumulation of OSEs and recognition of OSEs by designated pattern recognition receptors on immune cells or soluble effectors can contribute to the development of chronic inflammatory diseases. In line, recent studies highlight the involvement of modified lipids and OSEs in different stages of the spectrum of non-alcoholic fatty liver disease (NAFLD), including inflammatory non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. Targeting lipid peroxidation products shows high potential in the search for novel, better therapeutic strategies for NASH.

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Section: Ose Presence In Nafldmentioning

confidence: 99%

Oxidation-Specific Epitopes in Non-Alcoholic Fatty Liver Disease

Hendrikx

Binder

2020

Front. Endocrinol.

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“…NAFLD associates with low levels of serum plant sterols in cross-sectional studies [ 3 , 4 ] and plant sterols are suggested to prevent the progression of NAFLD [ 5 ]. Plant sterols and plant stanols are normal components of plants.…”

Section: Introductionmentioning

confidence: 99%

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

et al. 2018

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Background and aims: Non-alcoholic fatty liver disease (NAFLD) associates with low levels of serum plant sterols in cross-sectional studies. In addition, it has been suggested that the hepatic sterol transport mechanisms are altered in NAFLD. Therefore, we investigated the association between serum, liver and bile plant sterols and sitostanol with NAFLD.Methods: Out of the 138 individuals (age: 46.3 ± 8.9, body mass index: 43.3 ± 6.9 kg/m², 28% men and 72% women), 44 could be histologically categorized to have normal liver, and 94 to have NAFLD. Within the NAFLD group, 28 had simple steatosis and 27 had non-alcoholic steatohepatitis. Plant sterols and sitostanol were measured from serum (n=138), liver (n=38), and bile (n=41). The mRNA expression of genes regulating liver sterol metabolism and inflammation was measured (n=102).Results: Liver and bile sitostanol ratios to cholesterol were higher in those with NAFLD compared to those with histologically normal liver (all P<0.022). Furthermore, liver sitostanol to cholesterol ratio correlated positively with histological steatosis and lobular inflammation (rs > 0.407, P<0.01 for both). In contrast, liver sitosterol to cholesterol ratio correlated negatively with steatosis (rs = −0.392, P=0.015) and lobular inflammation (rs = −0.395, P=0.014). Transcriptomics analysis revealed suggestive correlations between serum plant sterol levels and mRNA expression.Conclusion: Our study showed that liver and bile sitostanol ratios to cholesterol associated positively and liver sitosterol ratio to cholesterol associated negatively with liver steatosis and inflammation in obese individuals with NAFLD..

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“…In fact, it is highly relevant to understand the associations and potential causalities regarding hepatic non-cholesterol sterols and liver health. The fascinating question is why on one side dietary supplementation of both plant sterol as well as plant stanol esters seems to protect against liver inflammation in animal models for NASH [ 2 , 3 ] whereas at the same time soy-based parenteral nutrition which is rich in plant sterols results in cholestasis, elevated transaminases and bilirubin levels, and liver damage [ 4 , 5 ]. To be able to understand these effects, there is a clear need for this type of fundamental data regarding differences in plant sterol and stanol concentrations in disease conditions, but also with respect to the potential effects of changing non-cholesterol sterol concentrations in that particular disease.…”

mentioning

confidence: 99%