Correction: Corrigendum: GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

Ramesh, Sunita A.; Tyerman, Stephen D.; Xu, Bo; Bose, Jayakumar; Kaur, Sarvpreet; Conn, Vanessa M.; Domingos, Patrícia; Ullah, Sana; Wege, Stefanie; Shabala, Sergey; Feijó, José A.; Ryan, Peter R.; Gilliham, Matthew

doi:10.1038/ncomms9293

Cited by 16 publications

(6 citation statements)

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“…organisms is amplified during early development by a system of gap junctions and ion channel-driven bioelectrical cues into animalwide axial patterning (the appearance of a new anatomical level -"whole body symmetry") (Levin, 2003(Levin, , 2006. The developmental control bioelectric network shares mechanistic evolutionary history with the nervous system, and the conservation extends not only to mechanisms of targeting connections [such as neural-like mechanisms deployed in plant pollen tubes (Palanivelu and Preuss, 2000)] but to the ubiquitous use of neurotransmitter molecules downstream of bioelectric driving forces [e.g., GABA and the serotonin-like Auxin used in many plants (Ramesh et al, 2015)]. An intermediate form (Prindle et al, 2015;Humphries et al, 2017;Lee et al, 2017;Liu et al, 2017).…”

Section: A B Cmentioning

confidence: 99%

The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition

2019

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All epistemic agents physically consist of parts that must somehow comprise an integrated cognitive self. Biological individuals consist of subunits (organs, cells, and molecular networks) that are themselves complex and competent in their own native contexts. How do coherent biological Individuals result from the activity of smaller sub-agents? To understand the evolution and function of metazoan creatures' bodies and minds, it is essential to conceptually explore the origin of multicellularity and the scaling of the basal cognition of individual cells into a coherent larger organism. In this article, I synthesize ideas in cognitive science, evolutionary biology, and developmental physiology toward a hypothesis about the origin of Individuality: "Scale-Free Cognition." I propose a fundamental definition of an Individual based on the ability to pursue goals at an appropriate level of scale and organization and suggest a formalism for defining and comparing the cognitive capacities of highly diverse types of agents. Any Self is demarcated by a computational surface -the spatio-temporal boundary of events that it can measure, model, and try to affect. This surface sets a functional boundarya cognitive "light cone" which defines the scale and limits of its cognition. I hypothesize that higher level goal-directed activity and agency, resulting in larger cognitive boundaries, evolve from the primal homeostatic drive of living things to reduce stress -the difference between current conditions and life-optimal conditions. The mechanisms of developmental bioelectricity -the ability of all cells to form electrical networks that process informationsuggest a plausible set of gradual evolutionary steps that naturally lead from physiological homeostasis in single cells to memory, prediction, and ultimately complex cognitive agents, via scale-up of the basic drive of infotaxis. Recent data on the molecular mechanisms of pre-neural bioelectricity suggest a model of how increasingly sophisticated cognitive functions emerge smoothly from cell-cell communication used to guide embryogenesis and regeneration. This set of hypotheses provides a novel perspective on numerous phenomena, such as cancer, and makes several unique, testable predictions for interdisciplinary research that have implications not only for evolutionary developmental biology but also for biomedicine and perhaps artificial intelligence and exobiology.

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Section: A B Cmentioning

confidence: 99%

The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition

2019

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“…Stomatal aperture plays a key role in plant drought tolerance [ 77 , 149 , 150 ]. Stomatal guard cells contain a large amount of ALMT protein [ 151 , 152 ], which is the key factor in stomatal movement. In 2021, Xu et al [ 153 ] showed that ALMT9 is the key GABA signal that regulates plant cells.…”

Section: Function and Mechanism Of Gaba In The Regulation Of The Abio...mentioning

confidence: 99%

GABA Metabolism, Transport and Their Roles and Mechanisms in the Regulation of Abiotic Stress (Hypoxia, Salt, Drought) Resistance in Plants

Yuan

Gong

et al. 2023

Metabolites

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γ- Aminobutyric acid (GABA) is a ubiquitous four-carbon non-protein amino acid. In plants, GABA is found in different cell compartments and performs different metabolic functions. As a signalling molecule, GABA participates in the regulation of tolerance to various abiotic stresses. Many research studies have found that GABA accumulates in large amounts when plants are subjected to abiotic stress, which have been demonstrated through the Web of Science, PubMed, Elsevier and other databases. GABA enhances the tolerance of plants to abiotic stress by regulating intracellular pH, ion transport, activating antioxidant systems and scavenging active oxygen species. In the process of GABA playing its role, transport is very important for the accumulation and metabolism pathway of GABA in cells. Therefore, the research on the transport of GABA across the cell membrane and the organelle membrane by transport proteins is a direction worthy of attention. This paper describes the distribution, biosynthesis and catabolism of GABA in plants. In addition, we focus on the latest progress in research on the transport of exogenous GABA and on the function and mechanism in the regulation of the abiotic stress response. Based on this summary of the role of GABA in the resistance to various abiotic stresses, we conclude that GABA has become an effective compound for improving plant abiotic tolerance.

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“…Several years ago, a putative GABA receptor – ALMT1 – was identified in plants ( Ramesh et al, 2015 ). This receptor belongs to the anion channel aluminium-activated malate transporter (ALMT) family (for a review of the ALMT family, see Sharma et al, 2016 ).…”

Section: Gabamentioning

confidence: 99%

“…ALMTs are not homo8logues of the animal GABA receptor. The only homology between animal GABA A ion-channel receptors and ALMT resides in a 12 amino acid motif ( Ramesh et al, 2015 ). A homologue of this peptide is found in most ALMT proteins ( Ramesh et al, 2016 ).…”

Section: Gabamentioning

confidence: 99%

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Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

Caspi

Pantazopoulou

Prompers

et al. 2023

eLife

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Intercellular signalling is an indispensable part of multicellular life. Understanding the commonalities and differences in how signalling molecules function in two remote branches of the tree of life may shed light on the reasons these molecules were originally recruited for intercellular signalling. Here we review the plant function of three highly studied animal intercellular signalling molecules, namely glutamate, γ-aminobutyric acid (GABA), and melatonin. By considering both their signalling function in plants and their broader physiological function, we suggest that molecules with an original function as key metabolites or active participants in reactive ion species scavenging have a high chance of becoming intercellular signalling molecules. Naturally, the evolution of machinery to transduce a message across the plasma membrane is necessary. This fact is demonstrated by three other well-studied animal intercellular signalling molecules, namely serotonin, dopamine, and acetylcholine, for which there is currently no evidence that they act as intercellular signalling molecules in plants.

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Correction: Corrigendum: GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

Abstract: The original version of this Article contained a typographical error in the spelling of the author Matthew Gilliham, which was incorrectly given as Matthew Gillham. This has now been corrected in both the PDF and HTML versions of the Article.

Cited by 16 publications

References 0 publications

The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition

The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition

GABA Metabolism, Transport and Their Roles and Mechanisms in the Regulation of Abiotic Stress (Hypoxia, Salt, Drought) Resistance in Plants

Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

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