Correction: Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans

Moyes, Catherine L.; Vontas, John; Martins, Ademir Jesús; Ng, Lee Ching; Koou, Sin Ying; Dusfour, Isabelle; Raghavendra, Kamaraju; Pinto, João; Corbel, Vincent; Weetman, David

doi:10.1371/journal.pntd.0009084

Cited by 22 publications

(23 citation statements)

References 1 publication

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“…The AHI and sleepiness metric benefits of BPAP are like CPAP. A potential benefit of BPAP over CPAP is the improved comfort due to a lower pressure during exhalation, which may improve patient adherence [ 88 ]. BPAP can be considered for patients intolerant of CPAP pressure or who require additional ventilatory support such as in the setting of obesity, chronic obstructive pulmonary disease, or neuromuscular disease.…”

Section: Managementmentioning

confidence: 99%

Obstructive Sleep Apnea and Cardiovascular Diseases: Sad Realities and Untold Truths regarding Care of Patients in 2022

Gunta

Jakulla

Ubaid

et al. 2022

Cardiovascular Therapeutics

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Obstructive sleep apnea (OSA) is one of the most common and serious sleep-related breathing disorders with a high prevalence among patients with cardiovascular (CV) diseases. Despite its widespread presence, OSA remains severely undiagnosed and untreated. CV mortality and morbidity are significantly increased in the presence of OSA as it is associated with an increased risk of resistant hypertension, heart failure, arrhythmias, and coronary artery disease. Evaluation and treatment of OSA should focus on recognizing patients at risk of developing OSA. The use of screening questionnaires should be routine, but a formal polysomnography sleep study is fundamental in establishing and classifying OSA. Recognition of OSA patients will allow for the institution of appropriate therapy that should alleviate OSA-related symptoms with the intent of decreasing adverse CV risk. In this review, we focus on the impact OSA has on CV disease and evaluate contemporary OSA treatments. Our goal is to heighten awareness among CV practitioners.

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Section: Managementmentioning

confidence: 99%

Obstructive Sleep Apnea and Cardiovascular Diseases: Sad Realities and Untold Truths regarding Care of Patients in 2022

Gunta

Jakulla

Ubaid

et al. 2022

Cardiovascular Therapeutics

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“…Historically, efforts to reduce viral transmission have focused on the use of chemical insecticides and the development of vaccines. However, with the rise of insecticide resistance 3 and the limited efficacy of vaccines 4 , there is a critical need for improved control strategies. Recently, molecular tools, such as broadly neutralizing antibodies 5 and encoded miRNA arrays 6,7 have been demonstrated to mitigate DENV and ZIKV transmission by mosquitoes.…”

Section: Introductionmentioning

confidence: 99%

Engineered Antiviral Sensor Targets Infected Mosquitoes

Benetta

López-Denman

et al. 2023

Preprint

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Escalating vector disease burdens pose significant global health risks, so innovative tools for targeting mosquitoes are critical. We engineered an antiviral strategy termed REAPER (vRNA Expression Activates Poisonous Effector Ribonuclease) that leverages the programmable RNA-targeting capabilities of CRISPR Cas13 and its potent collateral activity. Akin to a stealthy Trojan Horse hiding in stealth awaiting the presence of its enemy, REAPER remains concealed within the mosquito until an infectious blood meal is up taken. Upon target viral RNA infection, REAPER activates, triggering programmed destruction of its target arbovirus such as chikungunya. Consequently, Cas13 mediated RNA targeting significantly reduces viral replication and its promiscuous collateral activity can even kill infected mosquitoes. This innovative REAPER technology adds to an arsenal of effective molecular genetic tools to combat mosquito virus transmission.

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“…Two common pyrethroid resistance mechanisms in Ae . aegypti are target-site and metabolic resistance [ 6 , 14 ]. Target-site resistance is caused by single or multiple mutations in the sequence of a target protein, inducing insensitivity at the target site of an insecticide [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Insecticide Resistance Profiles and Synergism of Field Aedes aegypti from Indonesia

Silalahi

Chang

et al. 2022

PLoS Negl Trop Dis

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Information on the insecticide resistance profiles of Aedes aegypti in Indonesia is fragmentary because of the lack of wide-area insecticide resistance surveillance. We collected Ae. aegypti from 32 districts and regencies in 27 Indonesian provinces and used WHO bioassays to evaluate their resistance to deltamethrin, permethrin, bendiocarb, and pirimiphos-methyl. To determine the possible resistance mechanisms of Ae. aegypti, synergism tests were conducted using piperonyl butoxide (PBO) and S,S,S-tributylphosphorotrithioates (DEF). The Ae. aegypti from all locations exhibited various levels of resistance to pyrethroids. Their resistance ratio (RR50) to permethrin and deltamethrin ranged from 4.08× to 127× and from 4.37× to 72.20×, respectively. In contrast with the findings of other studies, most strains from the highly urbanized cities on the island of Java (i.e., Banten, Jakarta, Bandung, Semarang, Yogyakarta, and Surabaya) exhibited low to moderate resistance to pyrethroids. By contrast, the strains collected from the less populated Kalimantan region exhibited very high resistance to pyrethroids. The possible reasons are discussed herein. Low levels of resistance to bendiocarb (RR50, 1.24–6.46×) and pirimiphos-methyl (RR50, 1.01–2.70×) were observed in all tested strains, regardless of locality. PBO and DEF synergists significantly increased the susceptibility of Ae. aegypti to permethrin and deltamethrin and reduced their resistance ratio to less than 16×. The synergism tests suggested the major involvement of cytochrome P450 monooxygenases and esterases in conferring pyrethroid resistance. On the basis of our results, we proposed a 6-month rotation of insecticides (deltamethrin + synergists ➝ bendiocarb ➝ permethrin + synergists ➝ pirimiphos-methyl) and the use of an insecticide mixture containing pyrethroid and pyrimiphos-methyl to control Ae. aegypti populations and overcome the challenge of widespread Ae. aegypti resistance to pyrethroid in Indonesia.

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Correction: Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans

Cited by 22 publications

References 1 publication

Obstructive Sleep Apnea and Cardiovascular Diseases: Sad Realities and Untold Truths regarding Care of Patients in 2022

Obstructive Sleep Apnea and Cardiovascular Diseases: Sad Realities and Untold Truths regarding Care of Patients in 2022

Engineered Antiviral Sensor Targets Infected Mosquitoes

Insecticide Resistance Profiles and Synergism of Field Aedes aegypti from Indonesia

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