Correction: Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

Cohen, Lena; Sagi, Irit; Bigelman, Einat; Solomonov, Inna; Aloshin, Anna; Ben-Shoshan, Jeremy; Pasmanik-Chor, Metsada; Rozenbaum, Zach; Keren, Gad; Entin–Meer, Michal

doi:10.1371/journal.pone.0241419

Cited by 2 publications

(2 citation statements)

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“…MMP9, one of the matrix metalloproteinases (MMPs) that participates in matrix remodeling of tissues [ 16 , 17 ], and in cancer migration, invasion, and tumorigenesis [ 18 , 19 ], can be secreted by ICLCs such as TCs through homocellular junctions to interact with surrounding cells. It has been reported that downregulating MMP9 expression suppresses HCC metastasis [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis

Tian

Luan

et al. 2021

Cell Death Discov.

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In China, hepatocellular carcinoma (HCC) is considered a malignant tumor with poor prognosis, frequent metastasis, and a high relapse rate. Telocytes (TCs) participate in tumorigenic, invasive, and migratory processes by secreting functional proteins and transmitting cell-to-cell information, but their functions in HCC are still unknown. TC counts and MMP9 expression in liver cancer tissues were measured using immunohistochemistry, western blotting, and RT-PCR. Primary TCs from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in HCC, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo. TCs promoted HCC cell metastasis by MMP9 expression in vitro and in vivo. Platelet-derived growth factor-alpha (PDGF-α), secreted by HCC cells, activated the Ras/ERK signaling pathway in TCs, thereby increasing MMP9 expression; Moreover, miR-942-3p suppressed MMP9 expression in TCs. Our results reveal the role of TCs in HCC and the mechanisms by which they elicit their effects, and they may serve as novel prognostic markers for HCC.

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Section: Introductionmentioning

confidence: 99%

Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis

Tian

Luan

et al. 2021

Cell Death Discov.

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“…Extracellular matrix(ECM) procides mechanical and biochemical support to cells and constructs homeostasis of peripheral tissues, and they contain matrix metalloproteinases(MMPs), heparanases and aggrecanases, among others [21,22]. MMP-9, one of MMPs, not only participates in matrix remodeling of tissues [23,24] but also involves in migration, in vasion and tumorigenesis of cancer [25,26]. MMP-9 can be secreted by ICLC such as TCs through the way of homocellular junctions to interact with other surrounding cells.…”

Section: Introductionmentioning

confidence: 99%

Telocytes Promote the Metastasis of Hepatocellular Carcinoma by Activating ERK Signaling Pathway and Sponging miR-942-3p to Impact MMP9

Xu¹,

Tian²,

Luan³

et al. 2021

Preprint

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Background: Hepatocellular carcinoma(HCC) in China is considered as a familiar malignant tumor with poor prognosis, high metastasis and disease relapse. Telocytes(TCs) have been verified to participate in progresses of tumorigenesis, invasions and migrations by secreting functional proteins and transmitting cell-to-cell information. Extracellular signal-regulared protein kinase(ERK) signal pathway is a vital mechanism driving cell proliferation, metastasis and apoptosis, but whether this molecular signaling mechanism contributes to matrix metalloproteinase-9(MMP) expression of TCs remains unclear. Methods: Telocytes and MMP9 expression in the liver cancer tissues are measured by immunohistochemistry assay, Westen blot assay and RT-PCR technique, meanwhile primary telocytes from liver para-cancer tissues are cultured in vitro. To demonstrate the function of telocytes for hepatocellular carcinoma, the metastatic cancer animal model is established by three typs of liver cancer cell-lines in vivo. Results: In our study, we elucidate that TCs in the para-cancer tissue can promote the metastasis of HCC cells by MMP-9 expression, in vitro and in vivo. PDGF derived from HCC cells has a capacity to activate Ras/ERK signaling pathway of TC as a result of accelerating MMP-9 expression, but it’s no significant for proliferative potential and apoptotic rate of TCs. While tyrosine kinase inhibitors and miR-942-3p suppress MMP-9 expression to make loss functions of TCs. Various mutations of TCs are also tested and single nucleotide polymorphisms of MMP-9 may be the potentially molecular mechanism of increasing protein expression in the invasive process of HCC. Conclusion: Our results demonstrate two potential mechanisms between HCC cells and TCs, suggesting that TC is a novel marker and target on deciphering reasons of cancer metastasis.

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Correction: Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

Cited by 2 publications

References 1 publication

Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis

Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis

Telocytes Promote the Metastasis of Hepatocellular Carcinoma by Activating ERK Signaling Pathway and Sponging miR-942-3p to Impact MMP9

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