Correction: Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

Wutka, Annika; Palagani, Vindhya; Barat, Samarpita; Chen, Xi; Khatib, Mona El; Götze, Julian; Belahmer, Hanane; Zender, Steffen; Bożko, Przemysław; Malek, Nisar P.; Plentz, Ruben R.

doi:10.1371/journal.pone.0162673

Cited by 3 publications

(1 citation statement)

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“…Thereby, capsaicin recruits several mechanisms of signaling for controlling migration and invasion. These include epithelial-mesenchymal transition (EMT) activation, AMP-activated protein kinase (AMPK), MMP signaling pathway, intracellular calcium elevation, VEGF, Wnt-Hedgehog control, tumor-associated NADH oxidase (tNOX), protein kinase B (Akt), MMPs, epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), p38 MAP kinase, RAC1, nuclear factor "kappa-light-chain-enhancer" of activated B-cells (NF-kB), and AP-1 [49][50][51][52][53][54]. Table 1 depicts the anticancer potential of capsaicin against various cancer cell lines.…”

Section: Capsaicin and Metastasismentioning

confidence: 99%

Anticancer Effect of Capsaicin and Its Analogues

Balasubramanian¹,

Ramalingam²

2020

Capsicum

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Potent biomolecules from natural products from plants, animals, and minerals are the fundamental basis of the ailment of mankind. Capsicum or red pepper plants were grouped under the kingdom Plantae and family Solanaceae. It is used widely throughout the world in foods for their pungent flavor and aroma, and to prolong food spoilage. This chapter presents a frame of a concise compilation of the anticancer and cytotoxic potentials of Capsicum, its analogs, and related compounds. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the most predominant and naturally occurring alkaloid from the Capsicum species. It also details the anticancer efficacy of capsaicin and its analogs like capsaicinoids and capsiates which possess antioxidants and targets multiple signaling pathways, ontogenesis, and tumor-suppressor genes in various types of cancer models. Capsaicin is a major ingredient and has been linked to suppression of growth in various cancer cells. The data available strongly indicate the significant anticancer benefits of capsaicin and its potent analog molecules. It shows a significant effect on cancer cell proliferation, apoptosis, cancer cell surveillance, growth arrest, and metastasis. This chapter also predominantly focuses on the combinational use of capsaicin with other natural dietary compounds as a measure of synergistic anticancer activities.

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