Correction: Cao, Z., et al. The Expression and Functional Significance of Runx2 in Hepatocellular Carcinoma: Its Role in Vasculogenic Mimicry and Epithelial—Mesenchymal Transition. Int. J. Mol. Sci. 2017, 18, 500

Cao, Zi; Sun, Bei; Zhao, Xiulan; Zhang, Yanhui; Gu, Qing; Liang, Xiaohui; Dong, Xueyi; Zhao, Nan

doi:10.3390/ijms22010077

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…This control guarantees the quantification of protein in all the lanes in the Western Blot despite small differences occurring while protein loading. There is an ample amount of vinculin in cells compared to other proteins [66,67] . Hence it serves as a good loading control.…”

Section: Invitro Studies Of Acb1 Acp1 and Acpm1 To Analyze Their Effe...mentioning

confidence: 99%

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Designing JAK2 Inhibitors Beyond Myeloproliferative Neoplasms ‐ Theoretical and Experimental Analysis for Solid Cancers

Achutha,

Krishna,

Pushpa

et al. 2024

ChemistrySelect

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Somatic mutations in JAK2 have been reported to cause myeloproliferative neoplasms, autoimmune disorders, rheumatoid arthritis, and inflammation. JAK2 protein with PDB id 3FUP was selected for docking analysis via cross‐docking. Molecular docking of JAK2 with ATP and crystal ligand revealed their binding affinities and interactions. 3D QSAR models with R2=0.997 and Q2=0.984 having high stability and predictivity were generated. The biological activity of the hit compound obtained from virtual screening, LAS 26879206, was predicted to be 4.21 using the 3D QSAR model. Modification of LAS 26879206 utilizing 3D QSAR contours for modulating its JAK2 inhibitory potential yielded two novel inhibitors with a 2‐aminopyrimidine core – ACP1 and ACPM1. Molecular docking, molecular dynamics simulations, and ADMET analysis indicated improvements in the efficiency of these compounds compared to the hit compound. Synthesis of these compounds was carried out using a two‐step reaction‐ first Buchwald – Hartwig coupling reaction to yield an intermediate ACB1 which was then coupled with appropriate boronic acids via Suzuki reaction to get ACP1 and ACPM1. The effects of these designed compounds as anticancer agents were analyzed in hCT‐116 (human colorectal carcinoma), HeLa (cervical carcinoma), A549 (human lung adenocarcinoma), and A375 (human melanoma) cell lines. ACPM1 was found to be active in all the cell lines with a pIC50 of 5 which was in concordance with the in silico studies. Western blot analysis validated the JAK2 inhibitory property of ACPM1 which can be further ensured by in vivo studies.

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Section: Invitro Studies Of Acb1 Acp1 and Acpm1 To Analyze Their Effe...mentioning

confidence: 99%

“…There is an ample amount of vinculin in cells compared to other proteins. [66,67] Hence it serves as a good loading control. The image of the gel membrane of Western Blotting is given in Supplementary Figure S16.…”

Section: Dft Analysismentioning

confidence: 99%

Designing JAK2 Inhibitors Beyond Myeloproliferative Neoplasms ‐ Theoretical and Experimental Analysis for Solid Cancers

Achutha,

Krishna,

Pushpa

et al. 2024

ChemistrySelect

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show abstract

“…Furthermore, introducing the low-cost Ni could obviously reduce the cost of the anode, which may increase the economic feasibility of DBFC. However, synthesizing polymetallic catalysts with specific structures and elemental distributions is quite challenging because nanomaterials with high entropy properties may be accompanied by the homogeneous mixing of atoms, [87][88][89] corresponding to harsh synthesis conditions and expensive processing costs. Consequently, the design and synthesis of composite metal catalysts with unique and stable structures are a global concern.…”

mentioning

confidence: 99%

Research progress on direct borohydride fuel cells

Liu,

Zhang,

Zhao

et al. 2024

Chem. Commun.

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Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression

Liu

et al. 2022

J Mol Med

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Correction: Cao, Z., et al. The Expression and Functional Significance of Runx2 in Hepatocellular Carcinoma: Its Role in Vasculogenic Mimicry and Epithelial—Mesenchymal Transition. Int. J. Mol. Sci. 2017, 18, 500

Abstract: The author wishes to make the following corrections to this paper [...]

Cited by 4 publications

References 1 publication

Designing JAK2 Inhibitors Beyond Myeloproliferative Neoplasms ‐ Theoretical and Experimental Analysis for Solid Cancers

Designing JAK2 Inhibitors Beyond Myeloproliferative Neoplasms ‐ Theoretical and Experimental Analysis for Solid Cancers

Research progress on direct borohydride fuel cells

Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression

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