Correction: Bishayee et al. Lotus (Nelumbo nucifera Gaertn.) and Its Bioactive Phytocompounds: A Tribute to Cancer Prevention and Intervention. Cancers 2022, 14, 529

Bishayee, Anupam; Patel, Palak A.; Sharma, Priya; Thoutireddy, Shivani; Das, Niranjan

doi:10.3390/cancers14092116

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Cited by 9 publications

References 2 publications

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Bioactive Compounds and Biological Activities of Lotus (Nelumbo nucifera Gaertn.)

Dandin,

Sebastian,

Dalavi

et al. 2023

Reference Series in Phytochemistry

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Bioactive Compounds and Biological Activities of Lotus (Nelumbo nucifera Gaertn.)

Dandin,

Sebastian,

Dalavi

et al. 2023

Reference Series in Phytochemistry

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Bioactive Compounds and Biological Activities of Lotus (Nelumbo nucifera Gaertn.)

Dandin,

Sebastian,

Dalavi

et al. 2024

Reference Series in Phytochemistry

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Immune-Enhancing Effects of Co-treatment With Kalopanax pictus Nakai Bark and Nelumbo nucifera Gaertner Leaf Extract in a Cyclophosphamide-Induced Immunosuppressed Rat Model

Park¹,

Lee²,

Shin³

et al. 2022

Front. Nutr.

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ObjectiveImmune system disorders can result in various pathological conditions, such as infections and cancer. Identifying therapies that enhance the immune response might be crucial for immunocompromised individuals. Therefore, we assessed the immune-enhancing effect of co-treatment with Kalopanax pictus Nakai Bark and Nelumbo nucifera Gaertner leaf extract (KPNN) in a cyclophosphamide (Cy)-induced immunosuppressed rat model.Materials and MethodsFor in vitro studies, macrophages and splenocytes were treated with various KPNN doses in the presence or absence of Cy. Macrophage viability, nitric oxide production, splenocyte viability, cytokine production and natural killer (NK) cell activity were analyzed. For in vivo studies, analysis of weekly body weight, dietary intake, tissue weight, immune-related blood cell count, cytokine levels, and spleen biopsy was performed in a Cy-induced immunocompromised animal model.ResultsKPNN significantly increased phospho-NF-κB and phospho-ERK protein levels and cell viability in macrophages. KPNN significantly increased the NK cell activity in splenocytes compared to that in the control. Cy treatment decreased tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interferon-γ production. In the Cy-induced immunosuppression rat model, KPNN-treated rats had significantly higher body weights and tissue weights than the Cy-treated rats. Additionally, KPNN treatment restored the immune-related factors, such as total leukocyte, lymphocyte, and intermediate cell contents, to their normal levels in the blood. The blood cytokines (TNF-α and IL-6) were increased, and spleen tissue damage was significantly alleviated.ConclusionsCollectively, KPNN exerts an immune-enhancing effect suggesting their potential as an immunostimulatory agent or functional food.

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Correction: Bishayee et al. Lotus (Nelumbo nucifera Gaertn.) and Its Bioactive Phytocompounds: A Tribute to Cancer Prevention and Intervention. Cancers 2022, 14, 529

Abstract: In the original article, there was a mistake in the legend for Table 2 [...]

Cited by 9 publications

References 2 publications

Bioactive Compounds and Biological Activities of Lotus (Nelumbo nucifera Gaertn.)

Bioactive Compounds and Biological Activities of Lotus (Nelumbo nucifera Gaertn.)

Bioactive Compounds and Biological Activities of Lotus (Nelumbo nucifera Gaertn.)

Immune-Enhancing Effects of Co-treatment With Kalopanax pictus Nakai Bark and Nelumbo nucifera Gaertner Leaf Extract in a Cyclophosphamide-Induced Immunosuppressed Rat Model

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