Correction: Antonelli, A., et al. Can Bone Compaction Improve Primary Implant Stability? An In Vitro Comparative Study with Osseodensification Technique. Applied Sciences 2020, 10, 8623

Antonelli, Alessandro; Bennardo, Francesco; Brancaccio, Ylenia; Barone, Selene; Femiano, F; Nucci, Ludovica; Minervini, Giuseppe; Lombardo, Fortunato; Attanasio, Ferdinando; Giudice, Amerigo

doi:10.3390/app11083427

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“…The property of spontaneous regeneration and self-bone healing can be used in maxillo-facial traumatology to treat unilateral mandibular subcondylar fractures using an acrylic splint for repositioning mandibular function [1]. Both bone compaction and osseodensification techniques have been demonstrated to enhance the primary implant stability in dental implantology [2], which is critical for edentulous jaw recovery [3]. The treatment of orofacial anomalies such as orofaciodigital syndrome, which is a group of hereditary diseases characterized by deformities of the face, mouth, feet, and hands, involves careful periodic follow-up and a multidisciplinary approach [4].…”

Section: Introductionmentioning

confidence: 99%

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism

Paz

Aviña

Cardona

et al. 2021

IJMS

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Vascularized composite allografts contain various tissue components and possess relative antigenicity, eliciting different degrees of alloimmune responses. To investigate the strategies for achieving facial allograft tolerance, we established a mouse hemiface transplant model, including the skin, muscle, mandible, mucosa, and vessels. However, the immunomodulatory effects of the mandible on facial allografts remain unclear. To understand the effects of the mandible on facial allograft survival, we compared the diversities of different facial allograft-elicited alloimmunity between a facial osteomyocutaneous allograft (OMC), including skin, muscle, oral mucosa, and vessels, and especially the mandible, and a myocutaneous allograft (MC) including the skin, muscle, oral mucosa, and vessels, but not the mandible. The different facial allografts of a BALB/c donor were transplanted into a heterotopic neck defect on fully major histocompatibility complex-mismatched C57BL/6 mice. The allogeneic OMC (Allo-OMC) group exhibited significant prolongation of facial allograft survival compared to the allogeneic MC group, both in the presence and absence of FK506 immunosuppressive drugs. With the use of FK506 monotherapy (2 mg/kg) for 21 days, the allo-OMC group, including the mandible, showed prolongation of facial allograft survival of up to 65 days, whereas the myocutaneous allograft, without the mandible, only survived for 34 days. The Allo-OMC group also displayed decreased lymphocyte infiltration into the facial allograft. Both groups showed similar percentages of B cells, T cells, natural killer cells, macrophages, and dendritic cells in the blood, spleen, and lymph nodes. However, a decrease in pro-inflammatory T helper 1 cells and an increase in anti-inflammatory regulatory T cells were observed in the blood and lymph nodes of the Allo-OMC group. Significantly increased percentages of donor immune cells were also observed in three lymphoid organs of the Allo-OMC group, suggesting mixed chimerism induction. These results indicated that the mandible has the potential to induce anti-inflammatory effects and mixed chimerism for prolonging facial allograft survival. The immunomodulatory understanding of the mandible could contribute to reducing the use of immunosuppressive regimens in clinical face allotransplantation including the mandible.

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Section: Introductionmentioning

confidence: 99%

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism

Paz

Aviña

Cardona

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Correction: Antonelli, A., et al. Can Bone Compaction Improve Primary Implant Stability? An In Vitro Comparative Study with Osseodensification Technique. Applied Sciences 2020, 10, 8623

Abstract: The author wishes to make the following corrections to this paper [...]

Cited by 1 publication

References 1 publication

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism

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