Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322

Alhamami, Tamara; Chowdhury, Piklu Roy; Gomes, Nancy; Carr, Mandi; Veltman, Tania; Khazandi, Manouchehr; Mollinger, Joanne L.; Deutscher, Ania T.; Turni, Conny; Mahdi, Layla K.; Venter, Henrietta; Abraham, Sam; Djordjevic, Steven P.; Trott, Darren J.

doi:10.3390/microorganisms10040825

Cited by 2 publications

(2 citation statements)

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“…Another obtained nding indicates that, M. haemolytica isolates were resistant to streptomycin, erythromycin, and clindamycin. This resistance may be linked to the widespread use of these drugs for disease prevention and treatment [47] This nding agrees with that of [48], who discovered that M. haemolytica isolates were 75% resistant to streptomycin. Furthermore, this outcome was consistent with a previous study from a Chinese veterinary clinic, in which the sick goat was given streptomycin on a regular basis, resulting in signi cant bacterial resistance.…”

Section: Discussionsupporting

confidence: 89%

MALDI TOF Mass Spectrometry and Molecular detection of Mannheimia haemolytica from sheep and goats in Holeta and Sebeta Town, Oromia Special Zone, Ethiopia

Umer,

Bulto,

Bekele

et al. 2023

Preprint

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Background:Mannhemia haemolytica is one of the most important bacteria among causative agent of pneumonic pasteurellosis in small ruminants throughout worldwide and it is also economically devastating pathogen in Ethiopia. Methods: A cross sectional study was carried out from November 2021 to May 2022 with the aim to identify Mannheimia haemolytica from sheep and goat in Sebeta and Holeta town, Oromia special zone, Ethiopia. A total of 235 samples (213 nasal swabs and 22 whole blood) were collected. Sheep and goat with clinical signs suggestive of pneumonic pasteurollosis were purposively sampling. Bacterial identification was conducted using biochemical, Biolog, Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI TOF MS) and Real time PCR detection. Moreover, antimicrobials susceptibility test was also conducted on the identified bacterial isolates using disc diffusion method. Results: The result showed that from a total of 235 samples, only two nasal swab samples were positive for M. haemolytica (0.85%). The two isolates were confirmed by all the tests and similar result was obtained by; biochemical, Biolog, MALDI TOF MS and real time PCR. Up on antimicrobial susceptibility testing, the two isolates were resistant to Streptomycin, Erythromycin and Clindamycin whereas they were susceptible to Tetracycline, Chloramphenicol, Trimethoprim/sulfonamides and Penicillin. Generally, this study revealed that M. haemolytica is among the causative agent of pneumonic pasteurellosis in sheep and goat in the study area. Although, the other remaining bacteria responsible for the disease. Conclusion: The research suggests that a combination of diagnostic methods such as MALDI TOF MS, Biolog, and real-time PCR should be used, as well as for a more in-depth investigation to identify the strain or serotype of M. haemolytica using advanced molecular sequencing and also analysis of the remaining causal agent from various species and locations in countries are significant to address the present vaccination and antibiotic resistance issues.

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Section: Discussionsupporting

confidence: 89%

MALDI TOF Mass Spectrometry and Molecular detection of Mannheimia haemolytica from sheep and goats in Holeta and Sebeta Town, Oromia Special Zone, Ethiopia

Umer,

Bulto,

Bekele

et al. 2023

Preprint

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“…Tetracycline, the sole representative of the tetracyclines class, displayed notable resistance levels. In view of this, resistance to this antibiotic should be monitored closely (Alhamami et al, 2022). The notable resistance levels of tetracycline could be attributed to various factors, including mechanisms of resistance and implications for human use.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance ofStaphylococcusspp. from human specimens submitted to diagnostic laboratories in South Africa, 2012–2017

Sigudu,

Qekwana,

Oguttu

2024

Preprint

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BackgroundAntimicrobial drug resistance is of public health importance due to its potential to reduce treatment options and increase healthcare expenditure. There is, however, a paucity of studies that have examined antimicrobial resistance in countries with poor to moderate income. The present study examined the patterns and predictors of antimicrobial resistance in Staphylococcus isolates collected from humans at diagnostic laboratories in South Africa between 2012 and 2017.Method and materialsA cross-sectional study design using retrospective data of 404 217 diagnostic laboratory records of staphylococcal isolates collected between 2012 and 2017 was adopted in this study. Isolates were assessed for antimicrobial drug resistance against 24 antimicrobials. Descriptive statistics, and binary logistic regression models were used to analyse the data. Significance was assessed at < 0.05.ResultsThe highest resistance was observed against Cloxacillin (70.3%), while the lowest resistance was against Colistin (0.1%). A significant (p < 0.05) decreasing trend in AMR was observed over the study period, while a significant increasing temporal trend (p < 0.05) was observed for MDR over the same period. A Significant (p < 0.05) association was observed between specimen type, species of organism, and year of isolation with AMR outcome. Significant (p < 0.05) associations were observed between specimen type and season, with MDR.Discussion and recommendationsThe observed high levels of AMR and the increasing temporal trend in MDR is of public health concern. Clinicians should consider these findings when deciding on therapeutic options. Continued monitoring of AMR amongStaphylococcusspp. and judicious use of antimicrobials in human medicine should be promoted.

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Correction: Alhamami et al. First Emergence of Resistance to Macrolides and Tetracycline Identified in Mannheimia haemolytica and Pasteurella multocida Isolates from Beef Feedlots in Australia. Microorganisms 2021, 9, 1322

Abstract: The authors wish to make the following corrections to this paper [...]

Cited by 2 publications

References 1 publication

MALDI TOF Mass Spectrometry and Molecular detection of Mannheimia haemolytica from sheep and goats in Holeta and Sebeta Town, Oromia Special Zone, Ethiopia

MALDI TOF Mass Spectrometry and Molecular detection of Mannheimia haemolytica from sheep and goats in Holeta and Sebeta Town, Oromia Special Zone, Ethiopia

Antimicrobial resistance ofStaphylococcusspp. from human specimens submitted to diagnostic laboratories in South Africa, 2012–2017

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