Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Vera, Lisse; Arias, Daimé Campos; Muylle, Sofie; Stergiopulos, Nikolaos; Segers, Patrick; Loon, Gunther van

doi:10.1371/journal.pone.0225396

Cited by 4 publications

(1 citation statement)

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“…The reason for the almost 50% underestimation of the NICOM could be the difference in cardio-vascular anatomy and physiology between human and equine patients as the used monitoring system is based on an algorithm developed for human patients. A recent study developed a 1D computer model for the equine arterial circulation comprising all major vessels of the arterial tree indicating significant differences in arterial pressure waves and wave forms as well as vessel performance for the horse ( 27 ). Furthermore, the significant differences in anatomy and physiology of the vascular structures between horses and humans and differences and cardiac performance such as stroke index and heart rate ( 28 , 29 ) make the translation of inbuilt algorithms difficult.…”

Section: Discussionmentioning

confidence: 99%

Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses

Hopster

Hurcombe

2021

Front. Vet. Sci.

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Bioreactance is the continuous analysis of transthoracic voltage variation in response to an applied high frequency transthoracic current and was recently introduced for non-invasive cardiac output measurement (NICOM). We evaluated NICOM compared to thermodilution (TD) in adult horses. Six healthy horses were used for this prospective, blinded, experimental study. Cardiac output (CO) measurements were performed simultaneously using TD and the bioreactance method. Different cardiac output scenarios were established using xylazine (0.5 mg/kg IV) and dobutamine (1.5–3 mcg/kg/min). Statistical analysis was performed by calculating the concordance rate, performing a regression analysis, Pearson correlation, and Bland Altman. The TD-based CO and NICOM values were highly correlated for low, normal and high CO values with an overall correlation coefficient. A 4-quadrant plot showed an 89% rate of concordance. The linear regression calculated a relationship between NICOM and TDCO of Y = 0.4874 · X + 0.5936. For the corrected Bland Altman agreement, the mean bias and lower/upper limits of agreement were −0.26 and −3.88 to 3.41 L/min, respectively. Compared to TD, bioreactance- based NICOM showed good accuracy at induced low, normal, and high CO states in normal horses. Future studies performed under more clinical conditions will show if this monitor can help to assess hemodynamic status and guide therapy in horses in ICU settings and under general anesthesia.

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Section: Discussionmentioning

confidence: 99%

Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses

Hopster

Hurcombe

2021

Front. Vet. Sci.

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Development of an atrial transseptal puncture procedure in horses to access the left heart: An ultrasound‐guided jugular vein and transhepatic approach

Vernemmen,

Van Steenkiste,

Buschmann

et al. 2024

Equine Veterinary Journal

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BackgroundRadiofrequency ablation has been successfully applied to treat right atrial arrhythmias in horses. Ablation of left‐sided arrhythmias requires a retrograde transarterial approach which is complicated. In human medicine, the left atrium is accessed through transseptal puncture (TSP) of the fossa ovalis (FO) using a caudal approach via the femoral vein.ObjectivesTo develop a zero fluoroscopy TSP technique for horses using a jugular vein (cranial) and transhepatic (caudal) approach.Study designIn vivo experimental study.MethodsTransseptal puncture was performed in 18 horses admitted for euthanasia and donated for scientific research under general anaesthesia: using a jugular vein approach (10 horses), a transhepatic approach (2 horses) or both (6 horses). Radiofrequency energy was applied on a guidewire to perforate the FO and allow sheath advancement under intracardiac and transthoracic echocardiographic guidance. Puncture lesions were inspected post‐mortem.ResultsTransseptal puncture was successful in 17/18 horses, of which 15/16 jugular vein approaches and 5/8 transhepatic approaches. Failure was due to technical malfunction, inability to advance the guidewire toward the heart and inability to advance the sheath through the FO. Intracardiac echocardiography was essential to safely guide the puncture process. Atrial arrhythmias caused by the TSP occurred in 13/18 horses. Puncture lesions were found in the right atrium in the FO region, and left atrium ventral to pulmonary vein ostium III.Main limitationsBecause in several horses two approaches were tested consecutively, it cannot be excluded that the second TSP was performed at the previous puncture site. Due to the developmental nature of the study the approaches were not randomised and did not allow comparison.ConclusionTransseptal puncture is feasible in horses using ultrasound guidance and allows for electrophysiological exploration of the left heart. Further studies are needed to evaluate post‐operative follow‐up.

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Bioreactance noninvasive cardiac output monitoring in euvolemic adult horses subjected with 7.2% saline and 6% hydroxyethyl starch (130/0.4) solution infusions

Long,

Hurcombe,

Hopster

2024

J Vet Emergen Crit Care

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ObjectiveTo compare the ability of bioreactance noninvasive cardiac output (BR‐NICO) with thermodilution cardiac output (TDCO) for the measurement of cardiac output (CO) in healthy adult horses receiving 2 different IV volume replacement solutions.DesignProspective randomized crossover study from September to November 2021.SettingUniversity teaching hospital.AnimalsSix university‐owned adult horses.InterventionsHorses were randomly assigned to receive 7.2% hypertonic saline solution (HSS) or 6% hydroxyethyl starch (130/0.4) solution (HETA). BR‐NICO and TDCO were measured simultaneously at baseline, 10, 20, 30, 40, 50, 60, 90, and 120 minutes before fluid administration and again at the same times after starting a bolus infusion of IV volume replacers. All solutions were administered within 10 minutes.Measurements and Main ResultsBR‐NICO and TDCO were strongly correlated (Pearson r2 = 0.93; P < 0.01). Regression analysis showed the relationship between TDCO and BR‐NICO was BR‐NICO = 0.48 × TDCO + 0.6. For the corrected BR‐NICO values, the Bland–Altman agreement mean bias and lower/upper limits of agreement were −0.62 and −5.3 to 3.9 L/min, respectively. Lin's concordance (95% confidence interval) between methods was 0.894 (0.825–1.097). Compared with baseline, HSS increased the CO at 10 and 20 minutes (TDCO and BR‐NICO). Compared with baseline, HETA decreased the CO at 10 and 20 minutes (TDCO and BR‐NICO) and increased the CO at 90 (TDCO only) and 120 minutes (TDCO and BR‐NICO).ConclusionsBR‐NICO strongly agreed with TDCO in the measurement of CO in healthy unsedated adult horses. HSS administration significantly increased CO in the first 30 minutes, while HETA initially decreased CO at 10 minutes but increased CO to above baseline values by 90 minutes.

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Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Cited by 4 publications

References 1 publication

Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses

Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses

Development of an atrial transseptal puncture procedure in horses to access the left heart: An ultrasound‐guided jugular vein and transhepatic approach

Bioreactance noninvasive cardiac output monitoring in euvolemic adult horses subjected with 7.2% saline and 6% hydroxyethyl starch (130/0.4) solution infusions

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