Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of Karachi

Asghar, Muhammad Sohaib; Kazmi, Syed Jawad Haider; Khan, Noman; Mohammed, Akram; Khan, Salman; Rasheed, Uzma; Hassan, Maira; Memon, Gul Muhammad

doi:10.7759/cureus.c34

Cited by 70 publications

(93 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another characteristic feature of our patients was loss of smell or taste. But this was only reported from Sri Lanka with a lower rate [11][12][13][14] .…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Clinical Characteristics of Noncritical Patients with Coronavirus Disease 2019 (COVID-19): Lessons from Bangladesh

Morshed¹,

Mosabbir

Chowdhury³

et al. 2020

Bangla. J. Microbiol.

View full text Add to dashboard Cite

The scientific literatures on clinical manifestations of coronavirus disease 2019 (COVID-19) patients from South Asian countries including Bangladesh are limited. Documentation of clinical spectrum from various geographic locations is vital for future scientific studies and clinical management. This study is aimed to report the sociodemographic and clinical characteristics of noncritical patients with COVID-19 in Bangladesh. We conducted a cross-sectional study at three dedicated COVID-19 hospitals of Bangladesh. The severity of the COVID-19 cases was assessed based on the WHO interim guidance. Data were collected only from non-critical COVID-19 patients as critical patients required immediate management. A total of 103 real-time polymerase chain reaction (RT-PCR) confirmed noncritical COVID- 19 patients were included. Most of the patients (71.8%) were male. Mild, moderate and severe illness were assessed in 74.76%, 9.71% and 15.53% of patients respectively. Nearly 52.4% patients had a co-morbidity, with hypertension being the most common (34%), followed by diabetes mellitus (21.4%) and ischemic heart disease (9.7%). Fever (78.6%), weakness (68%) and cough (44.7%) were the most common clinical manifestations. Other common symptoms included loss of appetite (37.9%), difficulty in breathing (37.9%), loss of taste or smell (35.0%), headache (32%) and body ache (32%). The median time from onset of the first symptom to attending hospitals was 7 days (interquartile range: 4 - 10). This study will help both the clinicians and epidemiologists to understand the magnitude and clinical spectrum of COVID-19 patients in South Asian perspective including Bangladesh. Bangladesh J Microbiol, Volume 37 Number 2 December 2020, pp 42-46

show abstract

“…Another characteristic feature of our patients was loss of smell or taste. But this was only reported from Sri Lanka with a lower rate [11][12][13][14] .…”

Section: Discussionmentioning

confidence: 84%

“…This is consistent with a summary report of 72,314 cases from China 15 . The severity of COVID-19 at presentation was not clearly mentioned in the early reports from the South Asian countries [11][12][13][14] . Most of the literature described the severity of illness among hospitalized patients.…”

Section: Discussionmentioning

confidence: 94%

Clinical Characteristics of Noncritical Patients with Coronavirus Disease 2019 (COVID-19): Lessons from Bangladesh

Morshed¹,

Mosabbir

Chowdhury³

et al. 2020

Bangla. J. Microbiol.

View full text Add to dashboard Cite

show abstract

“…We have observed increased frequency of these complications in COVID-19 ARDS patients compared to ARDS due to other causes. Our patients were mostly male with mean age of 59, which is the age group (50–70) associated with most critical course of COVID-19 in our country [ 8 , 9 ]. Diabetes and hypertension were the most common comorbid conditions, which coincides with COVID-19 dataset generated by the CDC from the 13 US states [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous emphysema and pneumomediastinum in patients with COVID-19 disease; case series from a tertiary care hospital in Pakistan

et al. 2021

View full text Add to dashboard Cite

Since December 2019, the clinical symptoms of coronavirus disease 2019 (COVID-19) and its complications are evolving. As the number of COVID patients requiring positive pressure ventilation is increasing, so is the incidence of subcutaneous emphysema (SE). We report 10 patients of COVID-19, with SE and pneumomediastinum. The mean age of the patients was 59 ± 8 years (range, 23–75). Majority of them were men (80%), and common symptoms were dyspnoea (100%), fever (80%) and cough (80%). None of them had any underlying lung disorder. All patients had acute respiratory distress syndrome on admission, with a median PaO2/FiO2 ratio of 122.5. Eight out of ten patients had spontaneous pneumomediastinum on their initial chest x-ray in the emergency department. The median duration of assisted ventilation before the development of SE was 5.5 days (interquartile range, 5–10 days). The highest positive end-expiratory pressure (PEEP) was 10 cmH2O for patients recieving invasive mechanical ventilation, while 8 cmH2O was the average PEEP in patients who had developed subcutaneous emphysema on non-invasive ventilation. All patients received corticosteroids while six also received tocilizumab, and seven received convalescent plasma therapy, respectively. Seven patients died during their hospital stay. All patients either survivor or non-survivor had prolonged hospital stay with an average of 14 days (range 8−25 days). Our findings suggest that it is lung damage secondary to inflammatory response due to COVID-19 triggered by the use of positive pressure ventilation which resulted in this complication. We conclude that the development of spontaneous pneumomediastinum and SE whenever present, is associated with poor outcome in critically ill COVID-19 ARDS patients.

show abstract

“…Around 90% of ICU patients along with non-survivors had NLR > 3 and one-half of them had NLR > 9 at admission. [86] PLR 30 M: 50 46% The PLR of patients might provide a new indicator in the monitoring of patients with COVID‐19: the higher PLR of patients during treatment, the longer time of the hospitalization. [66] 93 M: 46 40% The age and PLR of severe ill patients were significantly higher than those of non-severe patients.…”

Section: Prognostic Factors Associated With Lymphocytes In Covid-19mentioning

confidence: 99%

The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19

Delshad

Tavakolinia

Pourbagheri‐Sigaroodi

et al. 2021

International Immunopharmacology

View full text Add to dashboard Cite

show abstract

Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of Karachi

Cited by 70 publications

References 22 publications

Clinical Characteristics of Noncritical Patients with Coronavirus Disease 2019 (COVID-19): Lessons from Bangladesh

Clinical Characteristics of Noncritical Patients with Coronavirus Disease 2019 (COVID-19): Lessons from Bangladesh

Subcutaneous emphysema and pneumomediastinum in patients with COVID-19 disease; case series from a tertiary care hospital in Pakistan

The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19

Contact Info

Product

Resources

About