Correction: 3D printed nervous system on a chip

Johnson, Blake N.; Lancaster, Karen Z.; Hogue, Ian B.; Meng, Fanben; Kong, Yong Lin; Enquist, Lynn W.; McAlpine, Michael C.

doi:10.1039/c6lc90045c

Cited by 10 publications

(7 citation statements)

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“…The device exhibited well-regulated mechanical properties, long term stability in various environmental conditions, and optical transparency [ 275 ]. For the achievement of a balanced and stable structure with intricate micro-sized channels in the development of hydrogel-based OOC, different microfabrication technologies have been applied, including micro-molding [ 276 , 277 ], photo-patterning [ 278 , 279 ], and bioprinting [ 272 , 280 , 281 , 282 ]. With the recent progress in composite hydrogels and micro-technologies and the use of an effective combination of them, the fabrication of functional miniaturized organs to be used as disease models or in drug screening applications can soon be realized.…”

Section: Types Of Hydrogel Units Platforms and Fabrication Technologiesmentioning

confidence: 99%

Engineering Hydrogels for the Development of Three-Dimensional In Vitro Models

Maji

Lee

2022

IJMS

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The superiority of in vitro 3D cultures over conventional 2D cell cultures is well recognized by the scientific community for its relevance in mimicking the native tissue architecture and functionality. The recent paradigm shift in the field of tissue engineering toward the development of 3D in vitro models can be realized with its myriad of applications, including drug screening, developing alternative diagnostics, and regenerative medicine. Hydrogels are considered the most suitable biomaterial for developing an in vitro model owing to their similarity in features to the extracellular microenvironment of native tissue. In this review article, recent progress in the use of hydrogel-based biomaterial for the development of 3D in vitro biomimetic tissue models is highlighted. Discussions of hydrogel sources and the latest hybrid system with different combinations of biopolymers are also presented. The hydrogel crosslinking mechanism and design consideration are summarized, followed by different types of available hydrogel module systems along with recent microfabrication technologies. We also present the latest developments in engineering hydrogel-based 3D in vitro models targeting specific tissues. Finally, we discuss the challenges surrounding current in vitro platforms and 3D models in the light of future perspectives for an improved biomimetic in vitro organ system.

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Section: Types Of Hydrogel Units Platforms and Fabrication Technologiesmentioning

confidence: 99%

Engineering Hydrogels for the Development of Three-Dimensional In Vitro Models

Maji

Lee

2022

IJMS

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“…Schwann cells (S100b+) [47] Rat superior cervical ganglia (SCG) sensory neurons and hippocampal neurons Neurons (Tau+) [127] Rat NSCs Neurons (NF-H+); Astrocytes (GFAP+) [128] Established hiPSC-derived organ building blocks (OBBs) Neurons (TUBB3+) [69] hiPSC-derived spinal neuronal progenitor cells (sNPCs) Neurons (TUBB3+) [32] miPSC-derived oligodendrocyte progenitor cells (OPCs) Oligodendrocytes (labeled with enhanced green fluorescent protein or mCherry) [32] hiPSCs Neurons (MAP2+); GABA neurons (GABA+) Astrocytes (GFAP+)…”

Section: Primary Cellsmentioning

confidence: 99%

Bioprinting Neural Systems to Model Central Nervous System Diseases

Qiu

Bessler

Figler

et al. 2020

Adv Funct Materials

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To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell culture systems cannot recapitulate the in vivo complexity of neural systems. The search for valuable models of neurodegenerative diseases has recently been revived by the addition of 3D culture that allows to recreate the in vivo microenvironment including the interactions among different neural cell types and the surrounding extracellular matrix (ECM) components. In this review, the new challenges in the field of CNS diseases in vitro 3D modeling are discussed, focusing on the implementation of bioprinting approaches enabling positional control on the generation of the 3D microenvironments. The focus is specifically on the choice of the optimal materials to simulate the ECM brain compartment and the biofabrication technologies needed to shape the cellular components within a microenvironment that significantly represents brain biochemical and biophysical parameters.

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“…Microbes such as pseudomonas aeruginosa may induce vision-impairing corneal diseases after corneal injury or prolonged contact lens wear [ 116 , 117 ]. Until now, multiple viral infection in vitro models have been reconstituted, including hepatitis B virus infection study with human liver model, Coxsackievirus B research with gut-on-a-chip, pseudorabies virus integrated with neurological disorder model, and recent Covid-19 therapeutics with lung airway infection model [ [118] , [119] , [120] , [121] , [122] ]. Therefore, CoC systems provide an excellent opportunity to understand mechanisms of microbe-related disorders, and may exert great insights on the development of novel antibacterial and antivirus medicine suited for clinical practice.…”

Section: Discussionmentioning

confidence: 99%