CORR ® Tumor Board: Does Microwave Ablation of the Tumor Edge Allow for Joint-sparing Surgery in Patients with Osteosarcoma of the Proximal Tibia?

Evaluation of microwave ablation for local treatment of dogs with distal radial osteosarcoma: A pilot study

“…In our study, all samples were submitted for histopathology, and the results provided evidence of coagulative necrosis of the tumor. The argument can be made that thermal ablation can compromise the ability to determine surgical margins 30 . On the basis of our histopathology results, we know that there is tumor remaining 48 hours after ablation, although we cannot rule out that additional tissue necrosis may develop at a later point.…”

“…The increased kinetic energy from the oscillations creates heat that is evenly distributed through the tissue and kills tumor cells within the zone of ablation by heating the tissues to greater than 55°C to induce acute coagulative necrosis 26‐28 . More recently, local ablative techniques, such as MWA, have shown promise in the treatment of both benign and metastatic bone tumors in man, allowing preservation of limb function, pain palliation, and local tumor control 29‐31 . In a study of 104 human patients with primary pelvic malignancy that underwent MWA followed by reconstruction and stabilization with internal fixation, local recurrence (8.6%) and deep infection (5.6%) rates were lower than the local recurrence (21%–38%) and deep infection (21%–28%) rates that have been reported for en bloc resection followed by fixation 22 .…”