Corpus cancer.Clinical, pathological, and etiological aspects

Speert, Harold

doi:10.1002/1097-0142(194811)1:4<584::aid-cncr2820010406>3.0.co;2-2

Cited by 63 publications

(3 citation statements)

References 73 publications

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“…The HCS administered was Lederle Purified Placenta Protein (Lot #716049)5 which, in our hands, was about 75% as patent as the most highly purified Lederle Preparation (Lot #4 142-C-190-1) . 5 With the doses administered serum HCS concentrations were obtained which are comparable to those observed during the third trimester of human pregnancy (9).…”

supporting

confidence: 56%

Lactogenic Activity of Human Chorionic Somatomammotropin in Rhesus Monkeys

Beck

1972

Experimental Biology and Medicine

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Although human chorionic somztomammotropin (HCS)2 has been shown to induce the synthesis of casein-like phosphoproteins in pregnant mouse mammary gland explants (1) and to induce milk formation following its acute injection into the mammary ducts of rabbits sensitized with chorionic gonadotropin (2, 3) nothing is known about the effect of HCS on mammary gland function in primates. Because HCS and moakey chorionic somatomammo tropin are immunologically similar (4) , the present study was undertaken to determine whether HCS had any effect on mammary glands in nonpregnanlt Rhesus monkeys, and to determine whether HCS could alter milk production in female Rhesus monkeys with well-establishled lactation.Methods. To determine the effect of HCS on nonpregnant monkey mammary gland tissue in oioo, HCS, 17P-estradiol and progesterone were administered in lthe following combinations to female Rhesus monkeys weighing between 3.5 and 4.5 kg: 1 ) HCS, 25 mg twice daily for 7 days; 2) progesterone: 20 mg/day, and 17P-estradiol,3 5 mg/day for 4 weeks; 3) HCS plus progesterone plus 17P-estradiol in the same doses for 2 weeks. There were four monkeys in each treatment group. Breast biopsies were obtained by the method of Speert (5) before each treatmient anld at the end of each thera-

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supporting

confidence: 56%

Lactogenic Activity of Human Chorionic Somatomammotropin in Rhesus Monkeys

Beck

1972

Experimental Biology and Medicine

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“…CANCER January 1951 periments in which the lesion has been horirionally produced; it also includes correlative clinical data from patients will1 carcinoma of the fundus, such as a history of prolonged estrogen therapy, the high degree of coincidence between these tumors and other lesions associated with abnornlal estrogenic activity, namely, endornetrial hyperplasia, granulosacell tumors of the ovaries, and breast carcinoiria. 19 Speert'" presents some observations t o strengthen the relationship for an estrogenic factor in the developnient of carcinoma of the endoinetriuin by pointing out an abnorrnally high incidence of cirrhosis of tlie liver in patients with this type of tumor. In his series of twelve necropsietl cases of uterine carcinoma, Four h a d cirrhosis of the liver.…”

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confidence: 98%

Effect of portal cirrhosis on the development of carcinomas

Hall

Sun

1951

Cancer

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“…Current theories on breast development (see Folley, 1g47a ;Folley and Malpress, 1948, for reviews) suggest that the development of the duct system of the breast is due to oestrogens and the lobule-aveolar system to progesterone. That they can cause alveolar as well as duct development in the female monkey has been shown by Gardner and Van Wagenen (1938) ;Folley, Guthkelch and Zuckerman (1939) ; Gardner (1941) ; Speert (1948) ; but as Folley (1g47a) says, there may be some complementary effect of progesterone from the ovary or adrenal cortex. That they can cause alveolar as well as duct development in the female monkey has been shown by Gardner and Van Wagenen (1938) ;Folley, Guthkelch and Zuckerman (1939) ; Gardner (1941) ; Speert (1948) ; but as Folley (1g47a) says, there may be some complementary effect of progesterone from the ovary or adrenal cortex.…”

mentioning

confidence: 90%