Corpus callosum morphology across the lifespan in baboons (Papio anubis): A cross-sectional study of relative mid-sagittal surface area and thickness

Myelin characteristics of the corpus callosum in capuchin monkeys (Sapajus [Cebus] apella) across the lifespan

“…Westerhausen et al 15 also reported that the CC midsagittal area did not substantially decline from middle to late adulthood in chimpanzees. A similar pattern of slow, continuous growth and no decline in midsagittal area during late adulthood was reported for baboons 16 ( Papio anubis ) .…”

Heritability in corpus callosum morphology and its association with tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations

“…This shows that the results are largely reproducible despite the fact that the two chimpanzee cohorts differed in sample size and were scanned on machines with different magnet strengths. Regarding the contribution of subject factors, like in other nonhuman primates, 70,82,83 age appears to be a significant covariate and this is not surprising as previous studies in this same chimpanzee sample using this same method of quantifying CC morphology reported associations with age. 69 Sex also accounted for a small portion of variance in raw (isthmus)…”

“…Midsagittal callosal surface area and thickness were determined based on the T1-weighted images in native space using methods that have been described in detail elsewhere. 69,70 First, to obtain a non-tilted midsagittal slice, individual images were co-registered to a template using rigid-body transformation (i.e., preserving size and shape of the CC) in SPM12 rou- The midsagittal slice was identified using the criterion of minimal appearance of cerebral gray/white matter (lowest intensity) from regions adjacent to the longitudinal fissure. The cross-section of the CC was then manually traced on the midsagittal slice using MRIcron software.…”

Age- and sex-related differences in baboon (Papio anubis) gray matter covariation

“…These findings suggest that there are likely neurobiological changes occurring as baboons age. Although baboon neuroanatomy and function is well-studied (e.g., (Amiez et al, 2019;Atkinson et al, 2015;Black et al, 2009;Blaizot et al, 2004;Cain and Wada, 1979;Greer et al, 2002;Love et al, 2016;Marie et al, 2018;McBride et al, 1999;Meguerditchian et al, 2021;Rogers et al, 2007;Westerhausen and Meguerditchian, 2021), and postmortem studies reveal the development of tau pathology as they age (Schultz et al, 2000a;Schultz et al, 2002;Schultz et al, 2000b;Schultz et al, 2001), to date there have been few in vivo neuroimaging studies focused specifically on the aging baboon brain. Franke et al (Franke et al, 2017) found that prenatal undernutrition (70% of normal daily food intake) had long-term effects on the baboon brain, prematurely aging the young adult female baboon brain by 2.7 years on average.…”

“…More recently, Westerhausen and Meguerditchian (2021) examined corpus callosum morphology across the lifespan and found that the area of the corpus collosum increases slowly with age, particularly within the anterior section.…”