Corpus Callosum Diffusion Anisotropy and Hemispheric Lateralization of Language in Patients with Brain Arteriovenous Malformations

Li, Maogui; Wu, Jun; Jiang, Pengjun; Yang, Shuzhe; Guo, Rui; Yang, Yi; Cao, Yong; Wang, Shuo

doi:10.1089/brain.2020.0853

Cited by 2 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies on language reorganization revealed that the relation of the homologous areas through the callosal subregions is not limited to inhibition. Regarding the excitatory model, greater callosal connectivity based on FA was associated with decreased language lateralization in patients with brain tumors [ 66 ] and arteriovenous malformations [ 67 ]. Despite this conflict in the results, all together seem to be explained by the switching of inhibition or excitation according to the state of the brain.…”

Section: Discussionmentioning

confidence: 99%

Greater volumes of a callosal sub-region terminating in posterior language-related areas predict a stronger degree of language lateralization: A tractography study

et al. 2022

View full text Add to dashboard Cite

Language lateralization is the most intriguing trait of functional asymmetry for cognitive functions. Nowadays, ontogenetic determinants of this trait are largely unknown, but there are efforts to find its anatomical correlates. In particular, a white matter interhemispheric connection–the corpus callosum–has been proposed as such. In the present study, we aimed to find the association between the degree of language lateralization and metrics of the callosal sub-regions. We applied a sentence completion fMRI task to measure the degree of language lateralization in a group of healthy participants balanced for handedness. We obtained the volumes and microstructural properties of callosal sub-regions with two tractography techniques, diffusion tensor imaging (DTI) and constrained spherical deconvolution (CSD). The analysis of DTI-based metrics did not reveal any significant associations with language lateralization. In contrast, CSD-based analysis revealed that the volumes of a callosal sub-region terminating in the core posterior language-related areas predict a stronger degree of language lateralization. This finding supports the specific inhibitory model implemented through the callosal fibers projecting into the core posterior language-related areas in the degree of language lateralization, with no relevant contribution of other callosal sub-regions.

show abstract

Section: Discussionmentioning

confidence: 99%

Greater volumes of a callosal sub-region terminating in posterior language-related areas predict a stronger degree of language lateralization: A tractography study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…According to the authors, this might potentially signify a downregulation of interhemispheric connectivity (via the corpus callosum) mediated by this leftward structural asymmetry. Interestingly, small effects of increased FA within the corpus callosum have been associated with atypical language dominance in both healthy subjects ( R 2 = .082) (Häberling et al, 2011 ) and in patients with arteriovenous malformations (Li et al, 2021 ). One study has demonstrated a correlation between LI derived from tfMRI and an asymmetry of Meyer's loop in patients with epilepsy (Nowell et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Diffusion magnetic resonance imaging connectome features are predictive of functional lateralization of semantic processing in the anterior temporal lobes

Zahnert

Kräling

Melms

et al. 2022

Human Brain Mapping

View full text Add to dashboard Cite

Assessment of regional language lateralization is crucial in many scenarios, but not all populations are suited for its evaluation via task‐functional magnetic resonance imaging (fMRI). In this study, the utility of structural connectome features for the classification of language lateralization in the anterior temporal lobes (ATLs) was investigated. Laterality indices for semantic processing in the ATL were computed from task‐fMRI in 1038 subjects from the Human Connectome Project who were labeled as stronger rightward lateralized (RL) or stronger leftward to bilaterally lateralized (LL) in a data‐driven approach. Data of unrelated subjects ( n = 432) were used for further analyses. Structural connectomes were generated from diffusion‐MRI tractography, and graph theoretical metrics (node degree, betweenness centrality) were computed. A neural network (NN) and a random forest (RF) classifier were trained on these metrics to classify subjects as RL or LL. After classification, comparisons of network measures were conducted via permutation testing. Degree‐based classifiers produced significant above‐chance predictions both during cross‐validation (NN: AUC–ROC[CI] = 0.68[0.64–0.73], accuracy[CI] = 68.34%[63–73.2%]; RF: AUC–ROC[CI] = 0.7[0.66–0.73], accuracy[CI] = 64.81%[60.9–68.5]) and testing (NN: AUC–ROC[CI] = 0.69[0.53–0.84], accuracy[CI] = 68.09[53.2–80.9]; RF: AUC–ROC[CI] = 0.68[0.53–0.84], accuracy[CI] = 68.09[55.3–80.9]). Comparison of network metrics revealed small effects of increased node degree within the right posterior middle temporal gyrus (pMTG) in subjects with RL, while degree was decreased in the right posterior cingulate cortex (PCC). Above‐chance predictions of functional language lateralization in the ATL are possible based on diffusion‐MRI connectomes alone. Increased degree within the right pMTG as a right‐sided homologue of a known semantic hub, and decreased hubness of the right PCC may form a structural basis for rightward‐lateralized semantic processing.

show abstract

Corpus Callosum Diffusion Anisotropy and Hemispheric Lateralization of Language in Patients with Brain Arteriovenous Malformations

Cited by 2 publications

References 50 publications

Greater volumes of a callosal sub-region terminating in posterior language-related areas predict a stronger degree of language lateralization: A tractography study

Greater volumes of a callosal sub-region terminating in posterior language-related areas predict a stronger degree of language lateralization: A tractography study

Diffusion magnetic resonance imaging connectome features are predictive of functional lateralization of semantic processing in the anterior temporal lobes

Contact Info

Product

Resources

About