Corpus callosum development in childhood-onset schizophrenia

Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings

“…This study also found no differences in developmental trajectories of any measurement of corpus callosum area or volume (Johnson et al, 2013a). These results contrast those from an earlier, smaller study in the same group, which also reported normal initial total corpus callosum area, but showed a progressive decrease in the splenium area, which connects occipital cortical areas, beginning at age 22 (Keller et al, 2003b). An earlier study of brain volumes in COS patients found no difference in callosal volume in patients compared to healthy controls (Kumra et al, 2000).…”

Multimodal analyses identify linked functional and white matter abnormalities within the working memory network in schizophrenia

“…Although multiple regions of the corpus callosum have been reported as abnormal in SZ the largest effect size of FA reductions has been found in the splenium (Patel et al, 2011). Of particular relevance is the longitudinal study by Keller and colleagues (Keller et al, 2003) who reported failure of normal callosal growth in patients with early onset SZ resulting in area reductions, particularly in the splenium. The splenium receives fibers from the caudal two-thirds of the temporal lobe and from the medial occipital cortex (Dougherty et al, 2005).…”

A Comparison of Neuroimaging Findings in Childhood Onset Schizophrenia and Autism Spectrum Disorder: A Review of the Literature

“…Deficits in the corpus callosum have been inconsistently demonstrated in adult onset schizophrenia populations (95). In a longitudinal analysis of children and young adults with COS, differences in the midsagittal area of the splenium of the corpus callosum emerged around age 22, with patients having significantly smaller structures (98). Later analysis looking at volumetric differences in subsections of the corpus callosum revealed no differences between NIMH-COS patients, their siblings and controls with respect to overall volume, and/or volume change over time (99).…”