Corpus Callosum Damage and InterhemispherIc Transfer of Information following Closed Head Injury in Children

Benavidez, Debra A.; Fletcher, Jack Μ.; Hannay, H. Julia; Bland, Sondra T.; Caudle, Susan E.; Mendelsohn, Dianne B.; Yeakley, Joel W.; Brunder, Donald G.; Harward, Harriet; Song, James; Perachio, Nancy; Bruce, Derek A.; Scheibel, Randall S.; Lilly, Matthew A.; Verger-Maestre, K.; Levin, Harvey S.

doi:10.1016/s0010-9452(08)70803-7

Cited by 61 publications

(48 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although research examining the cognitive sequelae to callosal damage following TBI is limited, there are reports of callosal disconnection following severe TBI (Levander & Sonesson, 1998;Rubens et al, 1977;Vuilleumier & Assal, 1995), with patients displaying gross deficits in their ability to transfer and integrate information between hemispheres (e.g., apraxia, finger localization, dichotic listening), consistent with the deficits shown by patients who have had commissurotomies (e.g., Benavidez et al, 1999;Bentin et al, 1984;Damasio et al, 1980;Geffen et al, 1985). However, there do not appear to be any studies that have used information processing measures in order to detect more subtle deficits that may arise from less severe damage.…”

Section: Mild Traumatic Brain Injurymentioning

confidence: 79%

Neuropsychological and information processing deficits following mild traumatic brain injury

Mathias

Beall

Bigler

2004

J Int Neuropsychol Soc

119

View full text Add to dashboard Cite

Neuroradiological and neuropathological investigations have found evidence of diffuse brain damage in the frontal and temporal lobes, corpus callosum, and fornices in patients who have sustained a mild traumatic brain injury (TBI). However, neuropsychological assessments of these patients do not typically target many of the subtle information processing deficits that may arise from diffuse damage involving the frontotemporal regions of the brain as well as white matter pathology, including the corpus callosum. Consequently, we have a limited understanding of the deficits that may be attributable to temporary or permanent disruptions to these functional pathways. This study assessed a group of mild TBI patients (N 5 40) and a matched control group (N 5 40) on a number of standard neuropsychological tests of selective and sustained attention, verbal and non-verbal fluency, and verbal memory. In addition, reaction time (RT) tasks, requiring both the inter-and intra-hemispheric processing of visual and tactile information, were used to assess the functional integrity of the tracts that are likely to be affected by diffuse damage. In the 1st month after sustaining their injury, the mild TBI group demonstrated deficits in attention, non-verbal fluency, and verbal memory. They also demonstrated slower visual and tactile RTs, with the visual RTs of mild TBI patients being more affected by increased task difficulty and the need to transfer information across the corpus callosum, than did their matched controls. (JINS, 2004, 10, 286-297.)

show abstract

Section: Mild Traumatic Brain Injurymentioning

confidence: 79%

Neuropsychological and information processing deficits following mild traumatic brain injury

Mathias

Beall

Bigler

2004

J Int Neuropsychol Soc

119

View full text Add to dashboard Cite

show abstract

“…7 The reduction over time in CC volume, along with thinning of the CC, are thought to result from Wallerian degeneration following TBI. 9 The posterior region, or splenium, of the CC is especially vulnerable to TBI 10,11,12,13 Atrophy of the splenium of the CC has been observed following TBI. 14,15,16 Lesions in the posterior half of the CC accounted for 80% of all CC injuries in a study of 92 patients (i.e., ages 2-77, mean age 28) with severe TBI.…”

Section: Event-related Potential Measure Of Interhemispheric Transfermentioning

confidence: 99%

“…The hypothesis that the posterior CC is responsible for the interhemispheric transfer of visual information is supported by other studies, including a study examining commissurotomies in non-epileptic patients 25 and case studies of two patients with posterior CC sectioning for tumor removal, 26 as well as in a case study of one patient with hemialexia following posterior CC surgical sectioning. 27 Some evidence for impaired IHTT in TBI is provided by the performance of children with severe TBIs on a verbal dichotic listening task 10 and adults on visual and tactile reaction time tasks 20 that required IHTT. Although white matter atrophy was moderately related to visual and tactile reaction time task performance in adults, total CC area was not significantly related to performance on these tasks.…”

Section: Event-related Potential Measure Of Interhemispheric Transfermentioning

confidence: 99%

The UCLA Study of Children with Moderate-to-Severe Traumatic Brain Injury: Event-Related Potential Measure of Interhemispheric Transfer Time

Ellis

Marion

McArthur

et al. 2016

Journal of Neurotrauma

View full text Add to dashboard Cite

Traumatic brain injury (TBI) frequently results in diffuse axonal injury and other white matter damage. The corpus callosum (CC) is particularly vulnerable to injury following TBI. Damage to this white matter tract has been associated with impaired neurocognitive functioning in children with TBI. Event-Related Potentials can identify stimulus-locked neural activity with high temporal resolution. They were used in this study to measure interhemispheric transfer time (IHTT) as an indicator of CC integrity in 44 children with moderate/severe TBI at 3-5 months post-injury compared with 39 healthy control children. Neurocognitive performance was also examined in these groups. Nearly half of the children with TBI had IHTTs that were outside the range of the healthy control group children. This subgroup of TBI children with slow IHTT also had significantly poorer neurocognitive functioning than healthy controls-even after correction for premorbid intellectual functioning. We discuss alternative models for the relationship between IHTT and neurocognitive functioning following TBI. Slow IHTT may be a biomarker that identifies children at risk for poor cognitive functioning following moderate/severe TBI.

show abstract

“…44,45 WM and the CC after pediatric TBI The CC, the largest commissural white-matter bundle in the human brain, is the main route for interhemispheric transfer of information and is implicated in a large number of cognitive processes. [46][47][48][49][50] The CC is particularly vulnerable to injury in TBI. 46,51,52 DTI studies have shown lower FA and higher diffusivity metrics in all callosal subregions, relative to TD comparison groups, after TBI in both children and adults at subacute and chronic stages of recovery.…”

Section: 32mentioning

confidence: 99%

“…[46][47][48][49][50] The CC is particularly vulnerable to injury in TBI. 46,51,52 DTI studies have shown lower FA and higher diffusivity metrics in all callosal subregions, relative to TD comparison groups, after TBI in both children and adults at subacute and chronic stages of recovery. 44,45,[53][54][55][56] Given the proposed involvement of the CC in the bilateral frontoparietal neural networks underlying WM, 31,32 and its particular vulnerability to injury, reduced microstructural integrity of the CC may act as a neuropathological mechanism, possibly contributing to long-term WM deficits after pediatric TBI.…”

Section: 32mentioning

confidence: 99%

Working Memory and Corpus Callosum Microstructural Integrity after Pediatric Traumatic Brain Injury: A Diffusion Tensor Tractography Study

Treble

Hasan

Iftikhar

et al. 2013

Journal of Neurotrauma

View full text Add to dashboard Cite

Deficits in working memory (WM) are a common consequence of pediatric traumatic brain injury (TBI) and are believed to contribute to difficulties in a range of cognitive and academic domains. Reduced integrity of the corpus callosum (CC) after TBI may disrupt the connectivity between bilateral frontoparietal neural networks underlying WM. In the present investigation, diffusion tensor imaging (DTI) tractography of eight callosal subregions (CC1-CC8) was examined in relation to measures of verbal and visuospatial WM in 74 children sustaining TBI and 49 typically developing comparison children. Relative to the comparison group, children with TBI demonstrated poorer visuospatial WM, but comparable verbal WM. Microstructure of the CC was significantly compromised in brain-injured children, with lower fractional anisotropy (FA) and higher axial and radial diffusivity metrics in all callosal subregions. In both groups of children, lower FA and/or higher radial diffusivity in callosal subregions connecting anterior and posterior parietal cortical regions predicted poorer verbal WM, whereas higher radial diffusivity in callosal subregions connecting anterior and posterior parietal, as well as temporal, cortical regions predicted poorer visuospatial WM. DTI metrics, especially radial diffusivity, in predictive callosal subregions accounted for significant variance in WM over and above remaining callosal subregions. Reduced microstructural integrity of the CC, particularly in subregions connecting parietal and temporal cortices, may act as a neuropathological mechanism contributing to long-term WM deficits. The future clinical use of neuroanatomical biomarkers may allow for the early identification of children at highest risk for WM deficits and earlier provision of interventions for these children.

show abstract

Corpus Callosum Damage and InterhemispherIc Transfer of Information following Closed Head Injury in Children

Cited by 61 publications

References 37 publications

Neuropsychological and information processing deficits following mild traumatic brain injury

Neuropsychological and information processing deficits following mild traumatic brain injury

The UCLA Study of Children with Moderate-to-Severe Traumatic Brain Injury: Event-Related Potential Measure of Interhemispheric Transfer Time

Working Memory and Corpus Callosum Microstructural Integrity after Pediatric Traumatic Brain Injury: A Diffusion Tensor Tractography Study

Contact Info

Product

Resources

About