Corpus Callosum Atrophy in Wernicke's Encephalopathy

Lee, S.-T.

doi:10.1177/1051228405278352

Cited by 16 publications

(9 citation statements)

References 17 publications

(20 reference statements)

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“…Brain images of alcoholic patients with WE during the acute phase of the disease may differ from those of nonalcoholic patients. In fact, in patients with alcoholism, atrophy of the mamillary bodies, infratentorial regions, supratentorial cortex, and corpus callosum may be found in association with the alterations typical of WE [35,38]. In contrast, signal intensity alterations in nonalcoholic patients likely represent the first thiamine-related metabolic breakdown.…”

Section: Mri Findingsmentioning

confidence: 98%

Neuroimaging Findings in Acute Wernicke's Encephalopathy: Review of the Literature

Zuccoli

Pipitone

2009

American Journal of Roentgenology

267

189

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Wernicke's encephalopathy is characterized by a quite distinct pattern of MR alterations, which include symmetrical alterations in the thalami, mamillary bodies, tectal plate, and periaqueductal area, but atypical alterations may also been seen. A thorough knowledge of the neuroimaging findings of Wernicke's encephalopathy will assist in arriving at an early diagnosis, thus reducing the morbidity and mortality associated with this disease.

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Section: Mri Findingsmentioning

confidence: 98%

Neuroimaging Findings in Acute Wernicke's Encephalopathy: Review of the Literature

Zuccoli

Pipitone

2009

American Journal of Roentgenology

267

189

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“…6); the corpus callosum ( Fig. 5) [20,22,30]; the head of the caudate nucleus; and the frontal-parietal cortex [14,26,30] (Figs. 2, 4 and 6).…”

Section: Pathologymentioning

confidence: 99%

“…Involvement of the anterior portion of the trunk of the corpus callosum seems to be more frequent in chronic alcoholics and of the splenium in nonalcoholics più frequente negli etilisti cronici, quello dello splenio nei non-etilisti (Fig. 5) [20,22]. L'interessamento dei nuclei dei nervi cranici, invece, sarebbe caratteristico dei pazienti non-etilisti, tanto che alcuni autori ipotizzano un effetto protettivo dell'alcol nei confronti di tali regioni [32].…”

Section: Pathologyunclassified

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CT and MRI of Wernicke’s encephalopathy

et al. 2011

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The purpose of this pictorial essay is to present the computed tomography (CT) and magnetic resonance imaging (MRI) findings of Wernicke's encephalopathy, a rare, severe, acute neurological syndrome due to thiamine (vitamin B1) deficiency, associated with high morbidity and mortality. The classical clinical triad, which includes ocular signs, altered consciousness and ataxia, can be found in only one-third of patients. Although chronic alcoholic patients are the most commonly affected, Wernicke's encephalopathy may complicate malnutrition conditions in nonalcoholic patients, in whom it is greatly underestimated. CT and above all MRI of the brain play a fundamental role in diagnosing the condition and ruling out other diseases. MRI is the most sensitive technique and is required in all patients with a clinical suspicion of Wernicke's encephalopathy. Medial thalami, mamillary bodies, tegmentum, periaqueductal region, and tectal plate are typical sites of abnormal MRI signal. The dorsal medulla, red nuclei, cranial nerve nuclei, cerebellum, corpus callosum, frontal and parietal cerebral cortex are less common sites of involvement although they are more frequently affected in nonalcoholic patients. Paramagnetic contrast material may help to identify lesions not otherwise visible.

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“…[20][21][22][23][24][25] Involvement of the corpus callosum has also been reported. 26 Lesions appear hypointense to isointense on T1WI and hyperintense on T2WI; however, a hemorrhagic component may result in more variable signal changes. Lesions may show enhancement after gadolinium administration.…”

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confidence: 99%

Neuroimaging of Toxic and Metabolic Disorders

Arora

Neema²,

Stankiewicz³

et al. 2008

Semin Neurol

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Imaging of the brain, magnetic resonance imaging (MRI) in particular, is a key adjunctive tool in the diagnosis and management of toxic-metabolic disorders such as alcoholism, mitochondrial encephalopathies, disorders of iron or copper metabolism, exposure to carbon monoxide, radiotherapy, immunosuppressive agents, toluene, and recreational drugs. In this article, we review the neuroimaging findings of common toxic and metabolic disorders focusing on the role of conventional MRI. We also consider advanced imaging methods, such as magnetic resonance spectroscopy, diffusion MRI, and positron emission tomography. We hope this article will prove useful to trainees and practitioners in the clinical and imaging fields of the neurosciences.

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Corpus Callosum Atrophy in Wernicke's Encephalopathy

Abstract: This study suggests that the extent and location of corpus callosum atrophy differs between alcoholic WE and nonalcoholic WE, implying separate contribution of alcohol neurotoxicity and nutritional deficiency.

Cited by 16 publications

References 17 publications

Neuroimaging Findings in Acute Wernicke's Encephalopathy: Review of the Literature

Neuroimaging Findings in Acute Wernicke's Encephalopathy: Review of the Literature

CT and MRI of Wernicke’s encephalopathy

Neuroimaging of Toxic and Metabolic Disorders

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