Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study

Sarrazin, Sophie; d’Albis, Marc-Antoine; McDonald, Colm; Linke, Julia; Wessa, Michèle; Phillips, Mary L.; Delavest, Marine; Emsell, Louise; Versace, Amelia; Almeida, Jorge; Mangin, Jean François; Poupon, Cyril; Dudal, K. Le; Daban, Claire; Hamdani, Nora; Leboyer, Marion; Houenou, Josselin

doi:10.1503/jpn.140262

Cited by 57 publications

(24 citation statements)

References 41 publications

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“…Regarding the CC, BD patients presented decreased callosal volumes in the three subregions as compared to SZ patients and HC. These results are in agreement with the literature comparing BD patients with HC . In contrast, in accordance with some studies, SZ patients did not significantly differ from HC .…”

Section: Discussionsupporting

confidence: 93%

“…These results are in agreement with the literature comparing BD patients with HC. [14][15][16][17]30 In contrast, in accordance with some studies, SZ patients did not significantly differ from HC. [11][12][13] Among studies that compared BD to SZ patients, Sun et al 18 highlighted a sharper decrease in the CC in BD patients as compared to SZ patients and to HC, especially in the middle region and in the splenium.…”

Section: Callosal Volumesupporting

confidence: 89%

“…Thus, based on this finding, the CC might be a specific structural biomarker to be found more frequently in BD than in SZ. In addition, a study suggested that BD patients with a positive history of psychotic features have an increased callosal rostrum area as compared to BD patients who have never experienced psychotic symptoms during illness phases . Nevertheless, further work is necessary to confirm these findings and also to investigate the microstructure of the CC in order to better understand the pathophysiology of this structure in BD and SZ.…”

Section: Discussionmentioning

confidence: 99%

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Relationships between corpus callosum and language lateralization in patients with schizophrenia and bipolar disorders

et al. 2017

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Our study revealed that SZ patients displayed a reduction of the leftward functional lateralization for language; however, no reduction of CC volume was observed, whereas BD patients presented a decreased volume of the CC associated with a lower leftward asymmetry for language. The results of our study detected distinct anomalies in both SZ and BD that may be considered as specific biomarkers of these disorders related to neurodevelopmental models.

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Section: Discussionsupporting

confidence: 93%

Section: Callosal Volumesupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Relationships between corpus callosum and language lateralization in patients with schizophrenia and bipolar disorders

et al. 2017

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“…Clinical, genetic and neuroimaging studies suggested that there might be distinct patterns between patients with BD ( n = 53) with and without psychotic features ( n = 56). We thus repeated our analysis on patients with BD with and without psychotic features.…”

Section: Methodsmentioning

confidence: 99%

Cerebellar parcellation in schizophrenia and bipolar disorder

Laidi

Hájek

Španiel

et al. 2019

Acta Psychiatr Scand

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parcellation in schizophrenia and bipolar disorderObjective: The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. Methods: Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. Results: Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent-onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. Conclusion: Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD.

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“…An increased CC Area (CCA) was observed in children affected with Autism Spectrum Disorder [Wolff et al, 2015] and smaller CCAs were found in Schizophrenia patients [Bachmann et al, 2003, Rotarska-Jagiela et al, 2008]. Regional CC atrophy was observed in patients affected by Alzheimer's disease [Frederiksen et al, 2011, Hallam et al, 2008, Di Paola et al, 2010], in patients with Huntington's dementia [Di Paola et al, 2012, Rosas et al, 2010], in a sample of patients with mesial temporal lobe epilepsy [Schneider et al, 2014] and in patients with bipolar disorder [Sarrazi et al, 2015]. …”

Section: Introductionmentioning

confidence: 99%

Reliability of measuring regional callosal atrophy in neurodegenerative diseases

Schependom

Jain

Cambron

et al. 2016

NeuroImage: Clinical

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The Corpus Callosum (CC) is an important structure connecting the two brain hemispheres. As several neurodegenerative diseases are known to alter its shape, it is an interesting structure to assess as biomarker. Yet, currently, the CC-segmentation is often performed manually and is consequently an error prone and time-demanding procedure. In this paper, we present an accurate and automated method for corpus callosum segmentation based on T1-weighted MRI images.After the initial construction of a CC atlas based on healthy controls, a new image is subjected to a mid-sagittal plane (MSP) detection algorithm and a 3D affine registration in order to initialise the CC within the extracted MSP. Next, an active shape model is run to extract the CC. We calculated the reliability of most popular CC features (area, circularity, corpus callosum index and thickness profile) in healthy controls, Alzheimer's Disease patients and Multiple Sclerosis patients. Importantly, we also provide inter-scanner reliability estimates.We obtained an intra-class correlation coefficient (ICC) of over 0.95 for most features and most datasets. The inter-scanner reliability assessed on the MS patients was remarkably well and ranged from 0.77 to 0.97.In summary, we have constructed an algorithm that reliably detects the CC in 3D T1 images in a fully automated way in healthy controls and different neurodegenerative diseases. Although the CC area and the circularity are the most reliable features (ICC > 0.97); the reliability of the thickness profile (ICC > 0.90; excluding the tip) is sufficient to warrant its inclusion in future clinical studies.

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Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study

Cited by 57 publications

References 41 publications

Relationships between corpus callosum and language lateralization in patients with schizophrenia and bipolar disorders

Relationships between corpus callosum and language lateralization in patients with schizophrenia and bipolar disorders

Cerebellar parcellation in schizophrenia and bipolar disorder

Reliability of measuring regional callosal atrophy in neurodegenerative diseases

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