Corpus Callosotomy with Radiosurgery

Pencil, G.; Eder, Hans G.; Schroettner, Oskar; Leber, K.

doi:10.1097/00006123-199908000-00021

Cited by 66 publications

(46 citation statements)

References 18 publications

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“…Erickson's work established the major role of corpus callosum as the seizure propagation pathway in the monkeys. (Pendl, Eder et al 1999) Effect of the callosotomy in the seizure generalization has also been demonstrated in animal studies. (Crowell and Ajmone Marson 1972;Marcus and Watson 1966) …”

Section: Back Ground With Historical Developmentmentioning

confidence: 87%

“…(Wyler 1993) Currently, endoscopic anterior callosotomy and radiosurgical callosotomy are some new approaches attempted by some investigators. (Pendl, Eder et al 1999;Tubbs, Smyth et al 2004;Eder, Feichtinger et al 2006) Along with clinical application of callosotomy, experimental data has accumulated as well over the years. Erickson's work established the major role of corpus callosum as the seizure propagation pathway in the monkeys.…”

Section: Back Ground With Historical Developmentmentioning

confidence: 99%

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Corpus Callosotomy in Pediatric Intractable Epilepsy: Microsurgical Technique Implication and Variation

Park¹,

Kim²

2011

Epilepsy in Children - Clinical and Social Aspects

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Section: Back Ground With Historical Developmentmentioning

confidence: 87%

Section: Back Ground With Historical Developmentmentioning

confidence: 99%

Corpus Callosotomy in Pediatric Intractable Epilepsy: Microsurgical Technique Implication and Variation

Park¹,

Kim²

2011

Epilepsy in Children - Clinical and Social Aspects

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“…Since that time, refinements in surgical technique have reduced the initially steep morbidity and mortality of the procedure (97). As the major connective tract between the two cerebral hemispheres, the fibers of the corpus callosum play a major role in seizure generalization.…”

Section: Corpus Callosotomymentioning

confidence: 99%

Surgical strategies for pediatric epilepsy

Guan

Karsy

Ducis³

et al. 2016

Transl. Pediatr.

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Pediatric epilepsy is a debilitating condition that impacts millions of patients throughout the world. Approximately 20-30% of children with recurrent seizures have drug-resistant epilepsy (DRE).For these patients, surgery offers the possibility of not just seizure freedom but significantly improved neurocognitive and behavioral outcomes. The spectrum of surgical options is vast, ranging from outpatient procedures such as vagus nerve stimulation to radical interventions including hemispherectomy. The thread connecting all of these interventions is a common goal-seizure freedom, an outcome that can be achieved safely and durably in a large proportion of patients. In this review, we discuss many of the most commonly performed surgical interventions and describe the indications, complications, and outcomes specific to each.

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“…13,17 Radiosurgical corpus callosotomy may be a promising safe and noninvasive alternative to open callosotomy. 1,4,6,19,26 This modality of treatment can be used in situations where patients have more than 2 seizure types and after a failed partial callosotomy. Small case series and individual case reports have claimed that the noninvasive nature of radiosurgery may serve to avoid transient and permanent surgical morbidity, including the disconnection syndromes, related to surgical manipulation, frontal lobe retraction, and venous injury.…”

Section: Other Surgical Alternatives and Adjunctsmentioning

confidence: 99%

Corpus callosotomy in children with intractable epilepsy using frameless stereotactic neuronavigation: 12-year experience at The Hospital for Sick Children in Toronto

Jea

Vachhrajani

Johnson

et al. 2008

FOC

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Object Although corpus callosotomy has been used effectively since the late 1930s to treat severe, medically intractable seizure disorders, particularly atonic or drop-attack seizures, controversy remains as to when, how, and how much surgery should be performed. Intraoperative determination of the extent of callosotomy, the need to stage the procedure, and the side of the interhemispheric approach represent technical issues that remain debatable. The authors report the 12-year experience of the senior author as well as surgical outcomes with corpus callosotomy using a frameless stereotactic neuronavigation system (ISG View Wand and BrainLab). Methods Thirteen consecutive children at The Hospital for Sick Children underwent single-stage corpus callosotomy for medically intractable seizures. The mean age was 10.3 years. Five children underwent partial callosotomy, and 8 underwent complete callosotomy. The side of operative approach to avoid large parasagittal bridging veins was determined by preoperative study of 3D MR imaging/MR venography reconstructed by the neuronavigation system. The extent of callosotomy was determined using intraoperative feedback from the neuronavigation system and postoperative MR imaging. Results The extent of callosotomy determined by intraoperative neuronavigation and postoperative MR imaging correlated closely in all cases. There were no operative deaths. There was no significant postoperative morbidity related to venous infarction. Four of 5 patients in the partial callosotomy cohort and 7 of 8 patients in the complete callosotomy cohort showed significant improvement in seizure control. Conclusions The use of frameless stereotactic neuronavigation is a safe, effective, and important surgical adjunct in the planning and execution of successful corpus callosotomy in children with intractable epilepsy.

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Corpus Callosotomy with Radiosurgery

Abstract: The outcomes suggest that radiosurgical corpus callosotomy may be a promising alternative treatment to open callosotomy.

Cited by 66 publications

References 18 publications

Corpus Callosotomy in Pediatric Intractable Epilepsy: Microsurgical Technique Implication and Variation

Corpus Callosotomy in Pediatric Intractable Epilepsy: Microsurgical Technique Implication and Variation

Surgical strategies for pediatric epilepsy

Corpus callosotomy in children with intractable epilepsy using frameless stereotactic neuronavigation: 12-year experience at The Hospital for Sick Children in Toronto

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