Corpus Callosal Oligodendroglioma: A Rare Entity

Abstract

Introduction: Oligodendroglioma's (ODG) are primary glial brain tumors that are divided into classical and anaplastic ODG's. Common pathologies encountered in the corpus callosum include primary central nervous system lymphomas and glioblastoma. Corpus callosal ODG is a rare entity. Case Report: A 54 year old male presented with headache since 6 months and weakness of right upper and lower limbs since 4 months. Radiological imaging was suggestive of a heterogeneous minimally enhancing mass arising from the corpus callosum and extending bilaterally into the frontal lobes (left more than right). Left frontal craniotomy and tumor decompression was done. Final histopathological report was "oligodendroglioma grade II but likely to behave in an aggressive manner". Patient received adjuvant chemo-radiation and on his latest follow up two years post-surgery, radiological imaging showed only gliotic changes in the brain. Conclusion: Corpus callosal oligodendroglioma is a rare entity. The treatment for anaplastic and aggressive ODG's should include gross total resection (wherever possible) or tumor decompression followed by adjuvant chemo-radiation.

Multifocal oligodendroglioma with callosal and brainstem involvement

“…There have been isolated callosal oligodendroglioma reports as well. [ 3 , 5 ] Tumors with 1p and 19q codeletions have noteworthy imaging features. They are also more likely to have ill-defined margins on T1-weighted MRIs and tend to have calcification.…”