Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome

Yamaguchi, Yu; Yamada, Kotaro; Yoshikawa, Norishige; Nakamura, Kazuki; Haginaka, Jun; Kunitomo, Masaru

doi:10.1016/j.lfs.2006.08.007

Cited by 105 publications

(74 citation statements)

References 44 publications

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“…These results are consistent with the anti-diabetic and anti-oxidative activities of CRA reported previously. 3, 7 Increased expression of chemokines and adhesion molecules in vascular endothelial cells could be considered as an early sign of the atherogenic process. 22 The present immunohistochemical analysis showed that CRA treatment inhibited the expression of MCP-1 and CCR2 in aortic endothelium, but did not affect IL-8, ICAM-1 expression, indicating that MCP-1/CCR2 is a target of CRA.…”

Section: Discussionmentioning

confidence: 99%

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Chen

Yang

Zhang

et al. 2012

Circ J

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Section: Discussionmentioning

confidence: 99%

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Chen

Yang

Zhang

et al. 2012

Circ J

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“…These are widely distributed in fruit peel, leaves and stem bark (3). It has been demonstrated that several triterpenes have the ability to induce cancer cell apoptosis and prevent oxidative stress, inflammation and hypertension (4,5).…”

Section: Introductionmentioning

confidence: 99%

Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways

et al. 2012

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Abstract. The cytotoxic effect of pomolic acid (PA), a pentacyclic triterpene isolated from flowers of Osmanthus fragrans var. aurantiacus Makino, was investigated in SK-OV-3 human ovarian adenocarcinoma cells. PA dose-dependently inhibited the viability of SK-OV-3 cells. PA-induced apoptosis was further characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations. The number of cells immunostained with annexin V-fluorescein isothiocyanate (FITC) increased following treatment with PA. The sub-G1 cell populations also increased in PA-treated SK-OV-3 cells. PA induced the activation of caspase-8, -9 and -3, critical mediators of apoptosis signaling. PA decreased the mitochondrial transmembrane potential (∆Ψ m ), resulting in the activation of caspase-9. In addition, PA increased the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling-related death receptor 5 (DR5), mediating caspase-8-involved extrinsic pathway. Taken together, our results indicate that PA induces apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

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“…It contains corosolic acid (CA) (Fig. 1), a compound which prevents oxidative stress, inflammation, hypertension and so on ( 1 ). The hypoglycemic effect of CA has been reported by various experiments (2)(3)(4)(5).…”

mentioning

confidence: 99%

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Takagi

Miura

Ishibashi

et al. 2008

J Nutr Sci Vitaminol

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SummaryThe banaba leaf ( Lagerstroemia speciosa L.) has been used in traditional Oriental medicine to treat diabetes in the Philippines. It contains corosolic acid (CA), a compound which has a hypoglycemic effect. We examined the effect of CA on blood glucose levels and the hydrolysis of disaccharides in the small intestine in mice. CA (10 mg/kg body weight) improved hyperglycemia after an oral administration of sucrose, and significantly reduced the hydrolysis of sucrose in the small intestine. These results suggest that the hypoglycemic activity of CA is derived, at least in part, due to the inhibition of the hydrolysis of sucrose.

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Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome

Cited by 105 publications

References 44 publications

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

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