Coronin3 regulates gastric cancer invasion and metastasis by interacting with Arp2

Sun, Yi; Shang, Yulong; Ren, Gui; Zhou, Lin; Feng, Bin; Li, Kai; Deng, Lin; Liang, Jie; Lu, Yuanyuan; Wang, Xin

doi:10.4161/cbt.29501

Cited by 15 publications

(21 citation statements)

References 27 publications

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“…Microscope was used to count and calculated the relative cell motility activity by the formula below: relative cell motility activity=number of migrated or invaded cells from different groups/number of migrated or invaded cells from the control group. 8 At least 10 fields were calculated per group in each experiment.…”

Section: Cell Migration and Invasion Assaysmentioning

confidence: 99%

“…6 Coronin3 belongs to the subfamily of the short coronins, which expresses ubiquitously and plays roles in the progression of many cancer types. [7][8][9] It was reported to interact with the cofilin and Arp2/3 complex, which play an important role in cell division and migration of normal cells as well as tumor cells. 10 However, the effect of coronin3 in NPC and other mechanisms such as epithelial-to-mesenchymal transition (EMT) progression are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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<p>Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition</p>

Fan¹,

Wei²,

Ding³

et al. 2019

OTT

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Coronin3 is a cytoskeletal protein that has been implicated in metastasis in many cancer types. Here, we demonstrate its effect in nasopharyngeal carcinoma (NPC) and propose a new probable mechanism of CORO1C-mediated cell migration and invasion by regulation of epithelial-to-mesenchymal transition (EMT) and CDH11. Patients and methods: First, we measured the differential expression of CORO1C between NPC and non-NPC cells in both cell lines and clinical specimens, using public datasets. Then, we investigated its relationship with clinicopathological factors and its potential as a biomarker to predict the prognosis of NPC patients. We also explored its influence on the cell behaviors of migration and invasion by upregulating and downregulating the expression of CORO1C and attempted to determine the underlying mechanism. Results: The results verified our original hypothesis. CORO1C was overexpressed in both NPC cell lines and clinical specimens, in both public datasets and our own samples. NPC patients with lower CORO1C expression levels in primary cancer tissues had longer OS (hazard ratio [HR] 1.814, 95% CI 0.831-3.960, p=0.0341) and PFS (HR 1.798, 95% CI 0.907-3.564, p=0.0155), indicating that it could be used as a prognostic biomarker. It was also confirmed that CORO1C enhanced cells' migration and invasion abilities, by inducing morphological and marker changes typical of EMT. Finally, we found that expression was correlated with and regulated CDH11 expression in NPC cell lines. Conclusion: Our study provided evidence for the contribution of CORO1C to NPC metastasis, and indicated that it could be used as a new therapeutic target and prognostic biomarker.

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Section: Cell Migration and Invasion Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition</p>

Fan¹,

Wei²,

Ding³

et al. 2019

OTT

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“…By further analysis of the six parental genes of 10 differential circRNAs, we found that 7 tumors occurred during the development of tumors. The parental gene is mainly related to the cycle, apoptosis, migration and infiltration of tumor cells, and CORO1C has been reported to be involved in the development of gastric cancer [12][13] .…”

Section: Discussionmentioning

confidence: 99%

“…Correlation, CORO1C (also known as Coronin1c) has been reported to be involved in the migration and invasion of gastric cancer cells [12][13] , playing an important role in the development and metastasis of clinical gastric cancer. Therefore, we further screened the three differential circRNAs involved in CORO1C, and finally verified the RT-qPCR in each group of serum samples with hsa_circ_0000437 with the largest difference.…”

Section: Circrna-mirna Network Analysis Of Differentially Expressed Cmentioning

confidence: 99%

Analysis of serum CircRNA in related to gastric cancer

Chen

Gong

et al. 2019

Preprint

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Gastric cancer is one of the most common malignant tumors of the digestive tract and one of the leading causes of death in patients with malignant tumors worldwide. In recent years, with the deepening of circRNA research, more and more evidence indicates that circRNA plays an important role in the occurrence and development of human malignant tumors. This study firstly conducted a retrospective analysis of the case data of gastric cancer patients who were treated at the Wuwei Cancer Hospital between 2015 and 2017. Subsequently, 18 cases of primary gastric cancer patients and 9 healthy people in Wuwei, Gansu Province were used as controls. The high-throughput microarray technology was used to screen the circRNA expression profiles of healthy and gastric cancer patients, and the expression was expressed by bioinformatics methods. Differential circRNA was used for gene ontology (GO) and KEGG pathway analysis, using its enrichment to predict the relevant biological functions of the differentially expressed circRNA and its involved pathways, and predicting miRNAs interacting with differentially expressed circRNAs, and constructing circRNA-miRNA interaction network. Q-PCR, gene organization microarray and bioinformatics techniques were used to validate candidate differential circRNAs and their linear parental genes and regulatable miRNAs. The results showed that there were 137 circRNAs with significant expression differences (including up-regulation of 67 and down-regulation of 70) in gastric cancer patients, and their differential expression may be related to the occurrence and development of gastric cancer; by GO, KEGG enrichment analysis and Regulating miRNA predictive analysis, the gastric cancer-related GO classification, KEGG Pathway and circRNA-miRNA network were preliminarily obtained, suggesting that differential circRNA may participate in gastric cancer-associated GO classification and KEGG pathway by regulating the expression of parental genes and miRNAs to influence the occurrence and development of gastric cancer. Finally, by using has verified the has_circ_0000437 and its parental genes and regulatable miRNAs, it was found that has_circ_0000437 is highly expressed in gastric cancer patients, and has a certain diagnostic value for the clinical diagnosis of gastric cancer. It may regulate its linear parental gene and The expression of miRNAs affects the development, metastasis and prognosis of clinical gastric cancer.

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“…EFNB2 plays an important role in physiological and pathological angiogenesis, and its role in tumor vessel development has been extensively studied. EFNB2 has been shown to mediate perivascular invasion of glioblastoma stem-like cells (27). ACTR2 is known to be a major constituent of the ARP2/3 complex, which is located at the cell surface and is essential for cell shape and motility through lamellipodial actin assembly and protrusion.…”

Section: Identification Of Non-coding Rnasmentioning

confidence: 99%

LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM

Zheng

Kong

et al. 2020

Front. Oncol.

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Coronin3 regulates gastric cancer invasion and metastasis by interacting with Arp2

Cited by 15 publications

References 27 publications

<p>Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition</p>

<p>Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition</p>

Analysis of serum CircRNA in related to gastric cancer

LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM

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