Coronaviruses in Brazilian bats: A matter of concern?

Cibulski, Samuel Paulo; Lima, Francisco Esmaile de Sales; Roehe, Paulo Michel

doi:10.1371/journal.pntd.0008820

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…Interestingly, novel lineages of the Betacoronavirus genus found in insectivorous bats sampled in Costa Rica were found to be loosely related to any known Old-World bat betacoronavirus . This is consistent with patterns of viral diversi cation in Central and South America, suggesting that circulation of evolutionary distinct lineages of betacoronaviruses in the New World is higher than currently documented (Cibulski et al, 2020). We identi ed Vespertilionidae and Molossidae as the families with most newly predicted reservoirs in Central and South America.…”

Section: Highlighting Surveillance Priorities and Knowledge Gaps In B...supporting

confidence: 78%

A framework to predict zoonotic reservoirs under data uncertainty: a case study on betacoronaviruses

Tonelli,

Blagrove,

Wardeh

et al. 2024

Preprint

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1. Modelling approaches aimed at identifying currently unknown hosts of zoonotic diseases have the potential to make high-impact contributions to global strategies for zoonotic risk surveillance. However, geographical and taxonomic biases in host-pathogen associations might influence reliability of models and their predictions. 2. Here we propose a methodological framework to mitigate the effect of biases in host–pathogen data and account for uncertainty in models’ predictions. Our approach involves identifying “pseudo-negative” species and integrating sampling biases into the modelling pipeline. We present an application on the Betacoronavirus genus and provide estimates of mammal-borne betacoronavirus hazard at the global scale. 3. We show that the inclusion of pseudo-negatives in the analysis improves the overall performance of our model significantly (AUC = 0.82 and PR-AUC = 0.48, on average) compared to a model that does not use pseudo-negatives (AUC = 0.75 and PR-AUC = 0.39, on average), reducing the rate of false positives. Results of our application unveil currently unrecognised hotspots of betacoronavirus hazard in subequatorial Africa, and South America. 4. Our approach addresses crucial limitations in host–virus association modelling, with important downstream implications for zoonotic risk assessments. The proposed framework is adaptable to different multi-host disease systems and may be used to identify surveillance priorities as well as knowledge gaps in zoonotic pathogens’ host-range.

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Section: Highlighting Surveillance Priorities and Knowledge Gaps In B...supporting

confidence: 78%

A framework to predict zoonotic reservoirs under data uncertainty: a case study on betacoronaviruses

Tonelli,

Blagrove,

Wardeh

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Another study conducted in Zhoushan City, Zhejiang Province, found that out of 334 bats sampled, approximately 26% were naturally infected with oronaviruses (Hu et al, 2018). Recently, some authors has suggested that a complex concern such as the emergence of infectious diseases, especially in low-income countries, needs to be addressed using this key concept, in which particular characteristics of human, environmental, and animal health are considered in a unified way to more effectively detect, understand, prevent and, if necessary, to intervene aiming to solve related public health issues (Cibulski et al, 2020).…”

Section: Coronavirusesmentioning

confidence: 99%

Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses

Bonilla-Aldana¹,

Jimenez-Diaz²,

Arango-Duque³

et al. 2021

International Journal of Infectious Diseases

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Highlights Bats serve as natural reservoirs for a variety of viruses. Transmission of highly pathogenic viruses from bats has been suspected and linked to a spectrum of emerging infectious diseases in humans and animals worldwide. Examples of such viruses include Marburg, Ebola, Nipah, Hendra, Influenza A, Dengue, Equine Encephalitis viruses, Lyssaviruses, Madariaga and Coronaviruses, involving the now pandemic Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we provide a comprehensive review on the diversity, reservoirs, and geographical distribution of the main bat viruses and their potential for cross-species transmission.

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“…The recent and ongoing SARS-CoV-2 pandemic has put the role of bats as potential zoonotic virus reservoirs in the spotlight, thus leading to a race to identify potential biomes and hosts that could be harboring the next outbreak, including South American bats [ 26 ]. Tropical and subtropical regions are associated with various factors, such as evergreen forests, rich biomes, high mammal diversity and density, pasture areas and deforestation, and these factors make tropical and subtropical regions hotspots with a high risk of emergence of infectious diseases (EIDs) [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

The virome of the white-winged vampire bat Diaemus youngi is rich in circular DNA viruses

et al. 2022

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In the Neotropical region, the white-winged vampire bat ( Diaemus youngi ) is the rarest of the three species of vampire bats. This bat species feeds preferentially on bird blood, and there is limited information on the viruses infecting D. youngi . Hence, this study aimed to expand the knowledge about the viral diversity associated with D. youngi by sampling and pooling the lungs, liver, kidneys, heart, and intestines of all animals using high-throughput sequencing (HTS) on the Illumina MiSeq platform. A total of three complete and 10 nearly complete circular virus genomes were closely related to gemykrogvirus ( Genomoviridae family), smacovirus ( Smacoviridae family), and torque teno viruses (TTVs) ( Anelloviridae family). In addition, three sequences of bat paramyxovirus were detected and found to be closely related to viruses reported in Pomona roundleaf bats and rodents. The present study provides a snapshot of the viral diversity associated with white-winged vampire bats and provides a baseline for comparison to viruses detected in future outbreaks. Supplementary Information The online version contains supplementary material available at 10.1007/s11262-022-01897-6.

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Coronaviruses in Brazilian bats: A matter of concern?

Cited by 8 publications

References 14 publications

A framework to predict zoonotic reservoirs under data uncertainty: a case study on betacoronaviruses

A framework to predict zoonotic reservoirs under data uncertainty: a case study on betacoronaviruses

Bats in ecosystems and their Wide spectrum of viral infectious potential threats: SARS-CoV-2 and other emerging viruses

The virome of the white-winged vampire bat Diaemus youngi is rich in circular DNA viruses

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