Coronavirus outbreak in cheetahs: Lessons for SARS

Wilkerson, Alison J. Pearks; Teeling, Emma C.; Troyer, Jennifer L.; Bar‐Gal, Gila Kahila; Roelke, Melody E.; Marker, Laurie; Pecon-Slattery, Jill; O’Brien, Stephen J.

doi:10.1016/j.cub.2004.02.051

Cited by 33 publications

(35 citation statements)

References 8 publications

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“…In addition, the ever-decreasing habitat of most feline species may serve to increase inter-and intraspecies aggression, further facilitating the spread and cross-species transmission of infectious disease. Finally, decreased genetic diversity in most wild populations reduces the ability of these species to adapt to new viral outbreaks (25,30), decreasing the likelihood that naïve species will be able to undergo viral/host coevolution rendering their strain of FIV relatively benign, as has presumably occurred with the lion and the puma in the past (9).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and Genomic Divergence of Circulating Strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae Species

Troyer

Pecon-Slattery

Roelke

et al. 2005

J Virol

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138

259

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Feline immunodeficiency virus (FIV) infects numerous wild and domestic feline species and is closely related to human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). Species-specific strains of FIV have been described for domestic cat (Felis catus), puma (Puma concolor), lion (Panthera leo), leopard (Panthera pardus), and Pallas' cat (Otocolobus manul). Here, we employ a three-antigen Western blot screening (domestic cat, puma, and lion FIV antigens) and PCR analysis to survey worldwide prevalence, distribution, and genomic differentiation of FIV based on 3,055 specimens from 35 Felidae and 3 Hyaenidae species. Although FIV infects a wide variety of host species, it is confirmed to be endemic in free-ranging populations of nine Felidae and one Hyaenidae species. These include the large African carnivores (lion, leopard, cheetah, and spotted hyena), where FIV is widely distributed in multiple populations; most of the South American felids (puma, jaguar, ocelot, margay, Geoffroy's cat, and tigrina), which maintain a lower FIV-positive level throughout their range; and two Asian species, the Pallas' cat, which has a species-specific strain of FIV, and the leopard cat, which has a domestic cat FIV strain in one population. Phylogenetic analysis of FIV proviral sequence demonstrates that most species for which FIV is endemic harbor monophyletic, genetically distinct species-specific FIV strains, suggesting that FIV transfer between cat species has occurred in the past but is quite infrequent today.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence and Genomic Divergence of Circulating Strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae Species

Troyer

Pecon-Slattery

Roelke

et al. 2005

J Virol

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138

259

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“…Cats have well-described models for several deadly human viral diseases, notably HIV-AIDS-feline immunodeficiency virus, which is endemic in 14 free ranging species of Felidae including domestic cats [11]. Cats also harbor feline leukemia virus and feline sarcoma virus, which have laid groundwork for oncogene discoveries and a virulent model for SARS, feline coronavirus, and many others [10][11][12][13][14][15][16].…”

Section: Infectious Agentsmentioning

confidence: 99%

“…For example, cats, like dogs, enjoy extensive veterinary medical surveillance (second only to human medicine) and have 250 genetic diseases analogous to human disorders [4][5][6][7][8]. Feline infectious agents offer powerful natural models to human diseases including HIV-AIDS [feline immunodeficiency virus (FIV)], SARS (feline coronavirus-FCoV), avian influenza, neurotropic viruses [canine distemper virus (CDV)] and cancers [feline leukemia virus-feline sarcoma virus (FeLV/ FeSV)] [5][6][7][8][9][10][11][12][13][14][15][16]. Cats are a domesticated representative of the Felidae family, which includes some of the most successful, but now the most threatened, predator species on earth [1,2,17].…”

Section: Introductionmentioning

confidence: 99%

State of cat genomics

et al. 2008

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Our knowledge of cat family biology was recently expanded to include a genomics perspective with the completion of a draft whole genome sequence of an Abyssinian cat. The utility of the new genome information has been demonstrated by applications ranging from disease gene discovery and comparative genomics to species conservation. Patterns of genomic organization among cats and inbred domestic cat breeds have illuminated our view of domestication, revealing linkage disequilibrium tracks consequent of breed formation, defining chromosome exchanges that punctuated major lineages of mammals and suggesting ancestral continental migration events that led to 37 modern species of Felidae. We review these recent advances here. As the genome resources develop, the cat is poised to make a major contribution to many areas in genetics and biology.

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“…The absence of FIVpcoB in Florida panthers is puzzling but may be related to the relative, though recent (50 to 100 years), isolation of this population from contiguous puma habitat. It is possible that the transmission of a newly introduced FIVpcoA strain from puma to puma may have been facilitated among the Florida panthers by the limited ability of this highly inbred population to resist infection (30,38). While two SDRC pumas (Pco-F07 and -F20) harbored FIVpcoA isolates that did not align closely with bobcat sequences, we hypothesize that bobcats in the SDRC region harbor an "SDRC bobcat substrain" of FIVpcoA that would map with the puma isolates from this region.…”

Section: Figmentioning

confidence: 99%

Frequent Transmission of Immunodeficiency Viruses among Bobcats and Pumas

Franklin¹,

Troyer

TerWee³

et al. 2007

J Virol

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With the exception of human immunodeficiency virus (HIV), which emerged in humans after cross-species transmissions of simian immunodeficiency viruses from nonhuman primates, immunodeficiency viruses of the family Lentiviridae represent species-specific viruses that rarely cross species barriers to infect new hosts. Among the Felidae, numerous immunodeficiency-like lentiviruses have been documented, but only a few cross-species transmissions have been recorded, and these have not been perpetuated in the recipient species. Lentivirus seroprevalence was determined for 79 bobcats (Lynx rufus) and 31 pumas (Puma concolor) from well-defined populations in Southern California. Partial genomic sequences were subsequently obtained from 18 and 12 seropositive bobcats and pumas, respectively. Genotypes were analyzed for phylogenic relatedness and genotypic composition among the study set and archived feline lentivirus sequences. This investigation of feline immunodeficiency virus infection in bobcats and pumas of Southern California provides evidence that cross-species infection has occurred frequently among these animals. The data suggest that transmission has occurred in multiple locations and are most consistent with the spread of the virus from bobcats to pumas. Although the ultimate causes remain unknown, these transmission events may occur as a result of puma predation on bobcats, a situation similar to that which fostered transmission of HIV to humans, and likely represent the emergence of a lentivirus with relaxed barriers to cross-species transmission. This unusual observation provides a valuable opportunity to evaluate the ecological, behavioral, and molecular conditions that favor repeated transmissions and persistence of lentivirus between species.

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Coronavirus outbreak in cheetahs: Lessons for SARS

Cited by 33 publications

References 8 publications

Seroprevalence and Genomic Divergence of Circulating Strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae Species

Seroprevalence and Genomic Divergence of Circulating Strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae Species

State of cat genomics

Frequent Transmission of Immunodeficiency Viruses among Bobcats and Pumas

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