Coronavirus-nephropathy; renal involvement in COVID-19

Valizadeh, Rohollah; Baradaran, Azar; Mirzazadeh, Azin; Bhaskar, L. V. K. S.

doi:10.34172/jrip.2020.18

Cited by 48 publications

(53 citation statements)

References 7 publications

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“…Therefore, amidst the COVID-19 pandemic, which is already taking a toll on global health, early diagnosis and identification of the underlying etiology are essential to guide proper management. Appropriate infectious control, intravenous fluid management, and respiratory failure management can contribute to preventing further AKIs (2,(7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and acute kidney injury; a case report

et al. 2020

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Although there is no definitive evidence that coronavirus disease 2019 (COVID-19) affects the kidneys adversely, amongst those who develop severe COVID-19 infection and require hospitalization, acute kidney injury (AKI) was reported. Here, we report the clinical outcome associated with AKI in a 32-year-old man with confirmed COVID-19 infection with no prior history of renal malfunction. The AKI was identified during intensive care unit (ICU) course with the median creatinine and blood urea nitrogen values of 3.1 mg/dL (normal value: 0.6-1.2 mg/dL) and 145 mg/dL (normal value:15-45 mg/dL), respectively. Renal function of patients hospitalized with COVID-19 infection needs to be monitored regularly to intervene as early as possible and to prevent the development of AKI and further kidney complications.

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Section: Discussionmentioning

confidence: 99%

COVID-19 and acute kidney injury; a case report

et al. 2020

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“…Special attention is needed on control of classic risk factors for kidney damage as recent studies show that in patients confirmed with COVID-19 renal disturbances are common (58). Due to acute tubular necrosis induced by sepsis, hydration, cytokine storm syndrome, rhabdomyolysis and hypoxia, renal disorders caused by COVID-19 consist of acute renal damage, and have been detected direct invasion of the virus in renal tubular cells and interstitial or glomeruli (59). Moreover, acute renal damage in COVID-19 is strongly associated with a higher level mortality and morbidity, renal evolution being an indicator for survival with CoV infection (59).…”

Section: Are Diabetes Related Complications Expected To Worsen Upon Smentioning

confidence: 99%

“…Due to acute tubular necrosis induced by sepsis, hydration, cytokine storm syndrome, rhabdomyolysis and hypoxia, renal disorders caused by COVID-19 consist of acute renal damage, and have been detected direct invasion of the virus in renal tubular cells and interstitial or glomeruli (59). Moreover, acute renal damage in COVID-19 is strongly associated with a higher level mortality and morbidity, renal evolution being an indicator for survival with CoV infection (59). In a study on renal function of 59 infected SARS-CoV-2 patients, 63% of patients reported proteinuria.…”

Section: Are Diabetes Related Complications Expected To Worsen Upon Smentioning

confidence: 99%

“…Possible mechanisms may be due to dehydration, which may be related to fever or decreased fluid intake having various consequences on the kidneys, leading to a reduction in glomerular filtration rate and acute kidney damage (59). Other proposed mechanisms include COVID-19 sepsis, which leads to cytokine storm syndrome.…”

Section: Are Diabetes Related Complications Expected To Worsen Upon Smentioning

confidence: 99%

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COVID‑19 and diabetes mellitus: Unraveling the hypotheses that worsen the prognosis (Review)

et al. 2020

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the caused disease-coronavirus disease 2019 (COVID-19), has affected so far >6,000,000 people worldwide, with variable grades of severity, and has already inflicted >350,000 deaths. SARS-CoV-2 infection seems severely affected by background diseases such as diabetes mellitus and its related complications, that seem to be favoring the most severe manifestations of SARS-CoV-2 and, therefore, require special attention in clinical care units. The present literature review focus on addressing several hypotheses explaining why diabetic patients could develop multi-organ failure in severe acute respiratory syndrome coronavirus (SARS-CoV) infections. Undoubtedly, as diabetes related complications are present it is expected to emphasize the severity of the COVID-19. Dermatological complications can occur and worsen in diabetic patients, and diseases such as acanthosis nigricans and psoriasis are prone to more severe manifestations of COVID-19. Approaches to treat SARS-CoV-2 infected patients, based on different solutions i.e. plasma therapy, use of antiviral compounds, development of vaccines or new therapeutic agents are ongoing.

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“…Detection of viral RNA in urine and kidney tissue of SARS-CoV-2-infected patients indicates the kidney as a target of infection [2]. Several of the recent reviews have mentioned kidney manifestations of COVID-19 [3, 4]. While angiotensin-converting enzyme 2 (ACE2) receptors are the functional receptor for the SARS coronavirus, their presentation in the lower respiratory tract, kidney, duodenum, and small intestine might provide possible routes of entry for the SARS-CoV [5].…”

mentioning

confidence: 99%