Coronavirus in context: Scite.ai tracks positive and negative citations for COVID-19 literature

Khamsi, Roxanne

doi:10.1038/d41586-020-01324-6

Cited by 12 publications

(9 citation statements)

References 4 publications

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“…If post translational mechanisms (which are subject to adequate selection) play a significant role in immune response in Covid-19, then this may in part explain why patients recovered from Covid-19 quickly lose their antibodies (Long et al, 2020 ), why some do not have strong neutralizing antibodies to begin with, why infection may linger for some patients (Khamsi, 2020 ), why there is such a drastic diversity of neutralizing mAbs isolated from infected patients (Liu et al, 2020 ), or why there is such a marked diversity between neutralizing Ab titer and disease progression altogether (Jahanshahlu and Rezaei, 2020 ; Wu F. et al, 2020 ). If some cells or tissue do not harbor the appropriate post translational antibody modification machinery, or if it does not get adequately selected and upregulated, then this could result in a partial, incomplete or failed immune response, either locally or systemically.…”

Section: The Possible Role Of Rarely Recognized Antibody Diversification In Covid-19mentioning

confidence: 99%

Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic Treatment

Mueller¹

2021

Front. Physiol.

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The ongoing Covid-19 pandemic underscores the importance of finding effective and safe ways to combat the virus, and to optimally understand the immune response elicited upon natural infection. This likely involves all components of the immune system, both innate and adaptive. The impetus for the rapid development of prophylactic treatment options has led to an intense focus on neutralizing antibodies (Abs), and many novel and specialized platforms have been designed to achieve that goal. B-cell immunity relies on the generation of a diverse repertoire of Abs. Their structural variation is defined in terms of amino acid composition that is encoded in the genome or acquired through somatic mutations. Yet, key examples of frequently neglected antibody diversification mechanisms involving post-translational modifications such as N- or O-linked glycosylation are present in significant portions of the population. During the last few years, these and other beyond gene sequence determined humoral immune response mechanisms have in some specific cases revealed their potent immunomodulatory effects. Nonetheless, such more unusual mechanisms have not received much attention in the context of SARS-CoV-2. Thus, with specific focus on the latter, this paper presents, (1) the rationale for considering beyond sequence determined strategies, (2) evidence for their possible involvement in Covid-19 disease evolution, (3) consequences for vaccine design exemplified by one of the vaccine candidates that is currently undergoing trial, and (4) more general implications. Based on a critical interpretation of published literature, the hypotheses developed in this study point to a crucial role of non-genetic antibody diversification mechanisms in disease evolution to counteract unique immunogenicity determinants of SARS-CoV-2 infection. The involvement of post translational mechanisms may also help explain the widely varied immune response observed, not only among different patient groups, but also in terms of their observed incompatibility with SARS-CoV-2 infection in several human cell types. The article highlights potentials and challenges of these refined humoral immune response mechanisms to most optimally target non-genetic viral evasion strategies.

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Section: The Possible Role Of Rarely Recognized Antibody Diversification In Covid-19mentioning

confidence: 99%

Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic Treatment

Mueller¹

2021

Front. Physiol.

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“….' says [Giovanni] Colavizza [an AI scientist at the University of Amsterdam and visiting researcher at the Alan Turing Institute in London], who is a user of the platform and whose team has analyzed data from the start-up [Scite] in the past" [22]. A high count of mentioning citation statements may provide little more nuance or detail than a total citation count.…”

Section: Use Scite With a Grain Of Saltmentioning

confidence: 99%

“…To reflect this, Scite displays confidence levels for classifications and offers opportunities to flag misclassified cites [ 21 ]. Currently, “ ‘Most citations [in Scite] are classified as “mentions”, because the classifier is trained to be cautious …' says [Giovanni] Colavizza [an AI scientist at the University of Amsterdam and visiting researcher at the Alan Turing Institute in London], who is a user of the platform and whose team has analyzed data from the start-up [Scite] in the past” [ 22 ]. A high count of mentioning citation statements may provide little more nuance or detail than a total citation count.…”

Section: Use Scite With a Grain Of Saltmentioning

confidence: 99%

Scite

Brody

2021

jmla

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“…Getting right information at right time is the need of hour for the researchers working on COVID-19 to develop vaccines or drugs for controlling the pandemic. Scientific articles on COVID-19 are doubling every 14 days, 1,2 which makes the role of librarians crucial during this period. To maintain continuity of flow of information and serve the information needs, some libraries are still open.…”

mentioning

confidence: 99%

Libraries and COVID-19 Crisis: Research Gaps

Yuvaraj

2021

Asia Pac J Public Health

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Libraries since ages have remained at the forefront in preservation, organization, and dissemination of knowledge. In the health crisis created by COVID-19, most of the countries have implemented partial or complete lockdown as preventive measures to shield people from getting infected. Getting right information at right time is the need of hour for the researchers working on COVID-19 to develop vaccines or drugs for controlling the pandemic. Scientific articles on COVID-19 are doubling every 14 days, 1,2 which makes the role of librarians crucial during this period. To maintain continuity of flow of information and serve the information needs, some libraries are still open. 3 Libraries open during this period are offering document delivery services to researchers, scientists, and health workers, which raises some concerns and research gaps.Recent researches published in the Journal of Hospital Infection and New England Journal of Medicine have revealed the survival of COVID-19 virus on various inanimate surfaces (like metal, glass, plastic) and in the air. But no research has yet been conducted on the transmission of corona virus through library document surfaces like book cloth, book jackets, coated and uncoated papers, which is an alarming situation for librarians and users. Sanitizing and disinfecting the documents is, however, important for the libraries before delivering the documents to the users as a precautionary measure. But use of disinfectant and sanitizer may lead to material damages of library documents. Research needs to be carried out in this direction for developing a cleaning or disinfecting solvent that does not damage the library documents and is effective against COVID-19 infection. In order to ensure document delivery support to researchers and allow librarians during the COVID-19 pandemic, research gaps need to be filled at the earliest.

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Coronavirus in context: Scite.ai tracks positive and negative citations for COVID-19 literature

Cited by 12 publications

References 4 publications

Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic Treatment

Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic Treatment

Scite

Libraries and COVID-19 Crisis: Research Gaps

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