Coronavirus disease 2019 presenting with conjunctivitis as the first symptom

Casalino, Giuseppe; Monaco, Gaspare; Sarro, Paolo Plinio Di; David, Alessandro; Scialdone, Antonio

doi:10.1038/s41433-020-0909-x

Cited by 31 publications

(34 citation statements)

References 8 publications

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“…Twelve articles reported the age (median [interquartile range]: 52 years [40–65 years], n = 37) at the onset of COVID-19, 14,15,24,25,27–31,33–35 and 12 articles mentioned the sex of the patients, with 36 men and 12 women in total. 14 , 15 , 24 , 25 , 27 – 31 , 33 – 35 …”

Section: Resultsmentioning

confidence: 99%

“… 15 , 24 , 34 A history of prodromal ocular symptoms in patients with COVID-19 was described in 11 articles (12.5%, 13/104 cases). 14 , 15 , 24 , 25 , 27 – 29 , 31 , 33 – 35 Seven articles reported therapeutic management for ocular symptoms in patients with COVID-19—namely, a combination of oral valacyclovir and moxifloxacin 15 ; ribavirin eye drops 24 ; ganciclovir eye drops 25 ; topical application of antibiotic and corticosteroids 31 ; artificial tears and ganciclovir gel 34 ; oral administration of oseltamivir and hydroxychloroquine 33 ; and oral paracetamol and a tapering course of topically administered tobramycin and dexamethasone. 35 …”

Section: Resultsmentioning

confidence: 99%

“…Two patients were treated with a combination of antibacterial eye drops and corticosteroid eye drops. 31 , 35 However, the use of topical steroids as a treatment for viral keratitis may delay the recovery time and is a point of contention among clinicians. 44 Considering the lower possibility of severe keratoconjunctivitis caused by coronavirus compared to the risk associated with adenovirus, injudicious use of topical corticosteroid eye drops may only increase the risk of bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

“…33 Altogether, 1533 individuals with confirmed COVID-19 were identified from the 15 studies (Table). Twelve articles reported the age (median [interquartile range]: 52 years [40-65 years], n = 37) at the onset of COVID-19, 14,15,24,25,[27][28][29][30][31][33][34][35] and 12 articles mentioned the sex of the patients, with 36 men and 12 women in total. 14…”

Section: Study Characteristics and Demographic Featuresmentioning

confidence: 99%

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Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and Meta-Analysis

Inomata

Kitazawa

Kuno

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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This systematic review aimed to determine currently reported clinical and prodromal ocular symptoms in patients with coronavirus disease 2019 (COVID-19). METHODS. An online article search was performed in PubMed and EMBASE. Altogether 15 studies (retrospective, prospective, or case studies) involving 1533 patients with COVID-19, reporting on ocular symptoms, and with outcome data available were identified. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines were followed. Study-specific estimates (incidence rates of ocular symptoms in patients with COVID-19) of cases were combined using one-group meta-analysis in a random-effects model. RESULTS. Of all included studies, 11.2% (95% confidence interval, 5.5-16.9; 78/1526 cases) reported ocular symptoms. The most common ocular finding was conjunctivitis. Prodromal ocular symptoms occurred in 12.5% (13/104 cases) of patients with COVID-19. Positive real-time polymerase chain reaction results were obtained for 16.7% (10/60 cases) of conjunctival samples and 0% (0/17 cases) of tear samples. Twelve ocular conjunctival swab samples tested positive for SARS-CoV-2. Ten cases were from subjects showing ocular symptoms (16.7%, 10/60 cases), and the remaining two cases were from subjects without ocular manifestation (1.8%, 2/113 cases). Limitations included the short study period, small sample size, findings were limited to the Asian population, only seven articles included ophthalmologic examination details, and there is currently no consensus on COVID-19 management. CONCLUSIONS. Ocular symptoms may occur in the presymptomatic phase as a prodromal symptom (12.5%, 13/104 cases), suggesting the possibility of viral transmission from the conjunctiva.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristics and Demographic Featuresmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and Meta-Analysis

Inomata

Kitazawa

Kuno

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Respiratory transmission is proven to be the major route for COVID-19 infection [ 6 , 7 ], with ocular surface involvement in COVID-19 transmission being controversial [ 8 , 9 ]. Conjunctivitis and ocular surface inflammation were generally reported among COVID-19 patients [ 2 , [10] , [11] , [12] , [13] ]. Willcox et al have proposed that the ocular surface is a possible site of infection for COVID-19 [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of contact lens wearers’ attitude toward contact lens wear and care during Coronavirus Disease 2019 (COVID-19) pandemic: A cross-sectional online survey

Bakkar

Alzghoul

2021

Contact Lens and Anterior Eye

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COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several reports have provided conflicting recommendations regarding contact lenses (CL) use during COVID-19, causing confusion among CL wearers. The aim of this study is to assess CL wearers' attitudes toward CL wear and care during COVID-19 pandemic. Methods: A web-based cross-sectional online survey was used to assess the participants' attitude toward CL wear and care during the COVID-19 pandemic. The survey layout was based on Google form® specifically developed for CL wearers. Demographic characteristics and CL history and profile were also collected for each participant. Results: A total of 196 CL wearers completed the online survey with an average age was 26 (± 4.1) and 90.8 % of participants were females. As reported by the participants, social media was the main source of information about COVID-19. 38.8 % of the study population reported stopping CL wear during the pandemic. The main stated reason for lens discontinuation was decreased social activities during the pandemic. 61.2 % of participants continued lens wear, with the majority reported considerable changes in their behaviors toward CL wear and care during the pandemic. This includes reinforced hands cleaning before and after lens wear, disinfecting of CLs and CL case and less frequent CL aftercare visits. Conclusion:The majority of the study population have continued CL wear during the pandemic. Contact lens wearers reported profound changes in attitudes toward CL wear including improved care and maintenance. Additionally, changes in CL purchase habit have been reported with more tendency for online purchase. CL cessation has been associated with several perceived reasons mainly attributed to reduced outdoor activity and fear of ocular infection. Levels of compliance among CL wearers should be assessed and reinforced during the current pandemic and similar lockdown situation to reduce possible CL-related complications and dropout.

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Management of COVID-19 in Ophthalmology

Salvetat,

Zeppieri

2024

Advances in Experimental Medicine and Biology

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Coronavirus disease 2019 presenting with conjunctivitis as the first symptom

Cited by 31 publications

References 8 publications

Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and Meta-Analysis

Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and Meta-Analysis

Assessment of contact lens wearers’ attitude toward contact lens wear and care during Coronavirus Disease 2019 (COVID-19) pandemic: A cross-sectional online survey

Management of COVID-19 in Ophthalmology

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